Accuretic (Quinapril + Hydrochlorothiazide)
Pair: Blackmores Conceive Well Gold 28 Tablets + 28 Capsules Accuretic 10/12.5, quinapril hydrochlorothiazide tablets, blood pressure medication Australia, ACE inhibitor diuretic combination, EZ Chemist antihypertensive
What is Accuretic used for?
Accuretic is a prescription medicine used to treat high blood pressure (hypertension). It is a combination of quinapril, an ACE inhibitor, and hydrochlorothiazide, a thiazide diuretic. Together, they help lower blood p
Accuretic
Generic Name: Quinapril + Hydrochlorothiazide
Formulation: Oral tablets
Common Strengths: 10 mg/12.5 mg, 20 mg/12.5 mg
Pack Size: Varies (commonly 30 tablets)
Availability: Prescription only (Schedule 4 – Australia)
Quinapril hydrochloride – 10 mg or 20 mg

Hydrochlorothiazide – 12.5 mg

Other Popular/Common Names:
Quinapril HCTZ

ACE inhibitor + thiazide diuretic combo
Blood pressure tablets
Accuretic antihypertensive
Quinapril with water pill
Accuretic contains two active components that lower blood pressure via complementary mechanisms:
Quinapril is an ACE inhibitor that blocks the enzyme responsible for converting angiotensin I to angiotensin II, a chemical that narrows blood vessels. By inhibiting this conversion, blood vessels relax and widen, lowering blood pressure and reducing cardiac workload.

Hydrochlorothiazide is a thiazide diuretic that promotes the elimination of sodium and water through urine, which reduces blood volume and subsequently lowers blood pressure.
Together, they offer synergistic antihypertensive effects and are often used when a single medication is insufficient.
Management of essential hypertension (high blood pressure)

Second-line therapy in patients not adequately controlled on monotherapy

May reduce the risk of cardiovascular events such as stroke and heart attack in hypertensive individuals

Initial dose: 1 tablet (10 mg quinapril + 12.5 mg HCTZ) once daily

Maintenance dose: May be adjusted based on response; typical maximum dose is 20 mg quinapril/12.5 mg HCTZ once daily

Take at the same time each day, preferably in the morning to reduce nocturia

Swallow whole with water, with or without food

Dosage must be adjusted in renal impairment or electrolyte imbalance.
Prescription Required: Yes

Pregnancy Category: D (Contraindicated)

Not suitable for use in pregnancy or breastfeeding — especially when paired with Blackmores Conceive Well Gold

May be used in patients with mild to moderate hypertension not adequately controlled by either component alone
Common: Dizziness, headache, fatigue, dry cough (due to ACE inhibition), increased urination

Less Common: Rash, elevated potassium, low sodium, muscle cramps

Rare but serious: Angioedema, severe hypotension, pancreatitis, jaundice
Do not use during pregnancy — ACE inhibitors can harm fetal development

Avoid if you have angioedema history, severe renal impairment, or electrolyte imbalance

Use cautiously in those with diabetes, gout, or liver disease

Regular monitoring of blood pressure, kidney function, and electrolytes is essential

Avoid excessive sun exposure due to photosensitivity risk from hydrochlorothiazide
Potassium supplements or potassium-sparing diuretics: Risk of hyperkalemia

NSAIDs (e.g., ibuprofen): May reduce antihypertensive effect and impair kidney function

Lithium: Increased risk of toxicity

Diabetes medications: Monitor blood glucose — diuretics can increase blood sugar levels

Other antihypertensives: Additive blood pressure-lowering effect; monitor for hypotension

Drug Classification:
Pharmacologic Class: ACE Inhibitor + Thiazide Diuretic

Therapeutic Class: Antihypertensive combination

Regulatory Class: Schedule 4 (Prescription Only Medicine in Australia)

Frequently Asked Questions (FAQs):
Q1. Can I take Accuretic while trying to conceive or during pregnancy?
A: No. Accuretic is contraindicated in pregnancy and should be avoided in those trying to conceive. It can cause fetal harm. Switch to a safer alternative in consultation with your doctor.

Q2. How long does it take Accuretic to lower blood pressure?
A: You may notice improvements within 1 to 2 weeks, but full effects take up to 4 weeks. Continue taking it even if you feel well.

Q3. What should I do if I miss a dose?
A: Take it as soon as you remember unless it’s close to the next dose. Do not double the dose.

Q4. Can I take Accuretic with Blackmores Conceive Well Gold?
A: No. Since Accuretic is not recommended during preconception or pregnancy, it should not be combined with fertility or prenatal vitamins.

Q5. Does it affect potassium levels?
A: Yes. It may increase serum potassium (from quinapril) or decrease it (from HCTZ), so routine blood tests are important.

Clinical Evidence & Research:
Clinical trials have shown the quinapril-HCTZ combination is significantly more effective than monotherapy in reducing systolic and diastolic blood pressure.

Long-term use of ACE inhibitor–diuretic combinations has been shown to reduce cardiovascular risk, particularly in hypertensive patients with comorbidities.

A study published in The Lancet supports combination therapy for better compliance and tolerability in patients with moderate hypertension.

Storage Instructions:
Store below 25°C

Protect from moisture and heat

Keep tablets in original packaging

Keep out of reach of children
Buy Accuretic Tablets Online (Prescription Required)
Available at: EZ Chemist Online Pharmacy (Insert product-specific URL once live)
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