Acebel 100mg Tablets – Aceclofenac Pain Relief for Arthritis, Inflammation & Musculoskeletal Conditions | EZ Chemist Online Pharmacy
What is Acebel (Aceclofenac) used for?
Acebel contains aceclofenac 100mg, a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation associated with osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. It works by inhibiting prostaglandin synthesis, reducing swelling and pain in joints and muscles.

Product Name: Acebel

Generic Name: Aceclofenac

Strength: 100 mg

Form: Oral Tablets

Pack Size: Typically available in 10, 15, or 20 tablets

Drug Class: Non-Steroidal Anti-Inflammatory Drug (NSAID)

Brand Category: Prescription Medicine

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Aceclofenac 100 mg
Aceclofenac is a derivative of diclofenac, specifically developed for better gastrointestinal tolerability. It has strong anti-inflammatory, analgesic, and antipyretic properties.
Brand Names: Acebel, Hifenac, Zerodol, Acemiz
Generic Equivalents: Aceclofenac Tablets

Aceclofenac works by inhibiting the cyclooxygenase (COX) enzyme, particularly COX-2, which is responsible for the formation of prostaglandins involved in pain, swelling, and inflammation. It provides selective relief while minimizing gastrointestinal side effects compared to older NSAIDs.
A study published in Clinical Rheumatology (2001) compared aceclofenac to diclofenac and naproxen, finding superior tolerability and equivalent anti-inflammatory efficacy.

Acebel is indicated for the symptomatic treatment of:

Osteoarthritis

Rheumatoid Arthritis

Ankylosing Spondylitis

Musculoskeletal Pain

Low Back Pain

Post-operative Inflammation

Typical Adult Dose: One tablet (100 mg) twice daily, with or after meals.

Maximum Dose: 200 mg per day.

Route: Oral

Do not crush or chew the tablet; swallow whole with water.
Prescription Required: Yes

Pregnancy Category: Not recommended (especially in the third trimester)

Pediatric Use: Not established for children under 18

Geriatric Consideration: Use cautiously due to increased risk of GI bleeding and renal impairment
Common:
Nausea
Indigestion
Diarrhea
Dizziness
Abdominal discomfor

Peptic ulcers

Elevated liver enzymes

Hypersensitivity reactions

Renal impairment
Gastrointestinal Risk: May cause serious GI events including bleeding and ulcers, especially in the elderly.

Cardiovascular Risk: Prolonged use may increase the risk of heart attack or stroke.

Renal & Hepatic Monitoring: Required in long-term use.

Avoid with alcohol and smoking due to increased risk of GI side effects.
Acebel (Aceclofenac) may interact with:

Aspirin & other NSAIDs – Increased risk of GI bleeding

Warfarin or anticoagulants – Enhanced anticoagulant effect

Methotrexate – Increased toxicity

Lithium – Increased lithium plasma levels

Diuretics & ACE inhibitors – May reduce renal function

Drug interaction studies in European Journal of Clinical Pharmacology show that concurrent use of ACE inhibitors and NSAIDs like aceclofenac can lead to renal impairment.
Store below 25°C, away from moisture and heat

Keep out of reach of children

Frequently Asked Questions (FAQs):
Q1: What is Acebel used for?
Acebel is used for relieving pain and inflammation in conditions like arthritis, back pain, and musculoskeletal disorders.

Q2: Is Acebel safe for long-term use?
Long-term use should be monitored by a doctor due to potential risks to the stomach, heart, liver, and kidneys.

Q3: Can Acebel be taken with food?
Yes, it should be taken with food to minimize gastrointestinal side effects.

Q4: Is Acebel a steroid?
No, Acebel is a non-steroidal anti-inflammatory drug (NSAID).

Q5: Can pregnant women take Acebel?
No, especially during the third trimester. Always consult a doctor before use.

Q6: Is Acebel safe with other painkillers?
Avoid combining with other NSAIDs or aspirin to prevent adverse effects. Use only under medical advice.

Clinical Backing & References:
Huskisson EC et al. – Comparative study of aceclofenac and diclofenac in osteoarthritis (Clinical Rheumatology, 1996)

European Medicines Agency – Aceclofenac Pharmacology Review

Bloor M et al. – Pharmacokinetics and tolerability of aceclofenac (International Journal of Clinical Pharmacology, 2001)

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