Actoplus Met – Pioglitazone and Metformin Combination for Type 2 Diabetes | EZ Chemist Online Pharmacy
Actoplus Met Tablets – Pioglitazone & Metformin Combination for Type 2 Diabetes Control | Buy Online at EZ Chemist

What is Actoplus Met used for?
Actoplus Met is a prescription combination of pioglitazone and metformin used to manage type 2 diabetes mellitus in adults. It helps control blood sugar levels by improving insulin sensitivity and reducing hepatic glucose production, especially in patients inadequately controlled by metformin alone.

Product Name: Actoplus Met

Generic Name: Pioglitazone Hydrochloride + Metformin Hydrochloride

Form: Oral Tablets (Immediate-Release)

15 mg/500 mg

15 mg/850 mg

Drug Class: Antidiabetic agent (Thiazolidinedione + Biguanide combination)

Prescription Status: Rx – Prescription Required

Manufacturer: Takeda Pharmaceuticals (original brand); also available as generic

Buy Actoplus Met Online – EZ Chemist
Pioglitazone Hydrochloride (15 mg)

Class: Thiazolidinedione

Function: Enhances peripheral insulin sensitivity

Metformin Hydrochloride (500 mg / 850 mg)

Class: Biguanide

Function: Reduces hepatic glucose production and intestinal absorption of glucose

Other Common or Brand Names:
Actoplus Met XR (Extended-release version)

Generic Equivalents: Pioglitazone + Metformin HCl

Other Brands: Gluconorm-PG, Tripride (if combined with glimepiride), Pioz MF
Pioglitazone activates PPAR-gamma receptors, increasing insulin sensitivity in liver, muscle, and adipose tissues.
Metformin acts primarily by inhibiting hepatic gluconeogenesis and increasing peripheral glucose uptake.

Dual action makes this combination effective in lowering HbA1c and fasting blood glucose.

Type 2 Diabetes Mellitus (non-insulin-dependent diabetes)

Patients not adequately controlled with metformin monotherapy

May be part of combination therapy with sulfonylureas or insulin (with caution)
Strength Typical Starting Dose Max Daily Dose
15 mg/500 mg One tablet twice daily with meals As prescribed
15 mg/850 mg One tablet twice daily with meals As prescribed
Administration: Take with food to reduce gastrointestinal side effects.
Titration: Begin with lower strength to assess tolerance and glycaemic response.
Do not split/crush the tablet.
Indicated in adults with type 2 diabetes

Not for use in type 1 diabetes or diabetic ketoacidosis

Requires monitoring of liver function, renal function, and glycaemic parameters
Nausea
Diarrhea
Flatulence
Headache
Weight gain
Edema
Serious Adverse Effects:
Lactic Acidosis (metformin-related; rare but fatal if unrecognized)

Congestive Heart Failure (pioglitazone-related; dose-dependent)

Bladder Cancer Risk (linked to long-term pioglitazone use)

Bone Fractures (in women, with pioglitazone use)

Hepatic Dysfunction
Lactic Acidosis: Risk increased in renal/hepatic impairment, alcohol abuse, dehydration

Heart Failure: Contraindicated in NYHA Class III/IV heart failure

Liver Monitoring: Required before and during treatment

Bladder Cancer Risk: Use cautiously in patients with active bladder cancer or history

Avoid Alcohol: May increase risk of lactic acidosis
Cimetdine: May increase metformin levels
Diuretics, ACE inhibitors: May alter glycaemic control
Insulin: Increased risk of fluid retention and heart failure
Corticosteroids & Oral Contraceptives: May increase blood glucose
A study published in The New England Journal of Medicine (2005) concluded that combination therapy with pioglitazone and metformin showed greater HbA1c reduction compared to monotherapy, but with increased risk of fluid retention.
Store at 20–25°C (68–77°F)

Keep away from moisture and direct sunlight

Keep out of reach of children

Frequently Asked Questions (FAQs):
Q1: What is Actoplus Met used for?
Actoplus Met is used to manage type 2 diabetes by improving insulin sensitivity and reducing liver glucose production.

Q2: Is Actoplus Met insulin?
No. It is an oral antidiabetic drug combination, not insulin.

Q3: Can I take Actoplus Met if I have kidney problems?
Not recommended in patients with moderate to severe renal impairment due to the risk of lactic acidosis.

Q4: Does Actoplus Met cause weight gain?
Pioglitazone can cause weight gain, especially if used with insulin.

Q5: Is Actoplus Met safe during pregnancy or breastfeeding?
Use only if clearly needed. Pioglitazone is not recommended in pregnancy. Discuss alternatives with your physician.

Q6: How long does it take for Actoplus Met to work?
Glucose-lowering effect begins within a few days, but full effects may take up to 2–3 weeks.

Clinical References and Studies:
DeFronzo R. et al. – Combination of pioglitazone/metformin in type 2 diabetes (NEJM, 2005)

FDA Prescribing Information – Actoplus Met label and safety updates

PubMed Clinical Review – Risk of lactic acidosis and bladder cancer in dual oral therapy

American Diabetes Association Guidelines – Combination therapy for type 2 diabetes management

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