Compared with: Blackmores Conceive Well Gold 28 Tablets + 28 Capsules
Advagraf Ointment, containing tacrolimus, is a topical immunosuppressant used to treat moderate to severe atopic dermatitis (eczema) when other treatments are ineffective or unsuitable. It reduces skin inflammation by modulating the immune response, providing long-term relief without the side effects of steroids.
Tacrolimus (as tacrolimus monohydrate)

Available in 0.03% and 0.1% topical formulations.
Tacrolimus Ointment

FK506
Protopic (a commonly used brand name globally)
Calcineurin Inhibitor
Non-steroidal eczema ointment
Note: Although Advagraf is primarily known as an extended-release oral formulation used in transplant medicine, when referred to in topical form, it aligns with tacrolimus topical products used in dermatology (e.g., Protopic). Ensure correct usage based on regional labeling.
Tacrolimus, the active compound in Advagraf ointment, is a calcineurin inhibitor. It inhibits T-cell activation and the release of inflammatory cytokines such as interleukin-2 (IL-2), which are responsible for the immune response in eczema and other inflammatory skin conditions. By modulating immune activity locally on the skin, it reduces redness, itching, and flare-ups without the skin thinning often caused by corticosteroids.
Advagraf (Tacrolimus) Ointment is indicated for:

Moderate to severe atopic dermatitis (eczema)

Eczema unresponsive to topical corticosteroids

Steroid-sparing therapy in chronic dermatitis

Facial or sensitive skin area eczema

Off-label uses: Vitiligo, lichen planus, seborrheic dermatitis (under dermatological guidance)

Dosage & Administration
Adults and children over 2 years: Apply a thin layer of ointment to the affected area twice daily.

Maintenance therapy: After improvement, frequency can be reduced to twice weekly to prevent flare-ups.

Application: Apply to clean, dry skin. Do not cover with occlusive dressings unless advised.

Treatment duration: Short-term and intermittent long-term use. Discontinue once lesions are cleared
0.03%: for children (2–15 years) and sensitive skin areas
0.1%: for adults and more severe cases
Form: Topical ointment
Strengths: 0.03% and 0.1%
Route: Cutaneous (topical)
Legal Category: Prescription Only Medicine
Storage: Store below 25°C. Do not refrigerate or freeze. Use within 30–60 days after opening.
Pregnancy: Category C – Use only if clearly needed and prescribed

Breastfeeding: Use with caution; avoid application on breast area

Children under 2 years: Not recommended

Sun Exposure: Minimise UV exposure during treatment; use sunscreen

Cosmetics: Can be applied after ointment is fully absorbed (~1 hour after application)
Burning or stinging at application site
Itching or redness
Skin tingling or discomfort (usually resolves in a few days)
Less common/serious effects:

Skin infections (bacterial, viral – e.g., herpes simplex)
Lymphadenopathy (swollen lymph nodes)
Rosacea-like symptoms

Photosensitivity

Rare: skin malignancies and lymphomas (long-term, though risk remains unconfirmed)
Do not apply to infected skin or open wounds

Avoid prolonged continuous use without breaks

Limit sun exposure and avoid tanning beds

Use only on areas prescribed by a dermatologist

Not to be used with occlusive dressings unless advised

Monitor for skin infections during use
Therapeutic Class: Dermatological, Immunosuppressant

Pharmacologic Class: Topical Calcineurin Inhibitor

Legal Status: Prescription Required (S4 – Australia, Rx – Other regions)
No significant systemic drug interactions expected due to minimal systemic absorption

Avoid concurrent topical corticosteroids unless prescribed

Phototherapy: Caution advised when combining with UV therapy due to increased risk of skin cance
Paller et al., NEJM 2001: Demonstrated superior efficacy of tacrolimus over placebo and comparable to mid-potency corticosteroids in atopic dermatitis.
Protopic Efficacy Trials: Showed significant improvement in facial and sensitive-area eczema with lower relapse rates.
Comparison with Blackmores Conceive Well Gold
While Advagraf Ointment is used to treat eczema by suppressing skin immune response, Blackmores Conceive Well Gold is designed to support female reproductive health and preconception nutritional needs. Both products serve distinct purposes. If a woman with eczema is preparing for conception, switching from steroids to non-systemic treatments like tacrolimus may be preferable under medical guidance.

FAQs – Advagraf Ointment (Tacrolimus)
Q1. What is Advagraf Ointment used for?
A: It is used to treat moderate to severe eczema (atopic dermatitis) that doesn't respond to other treatments.

Q2. Is it a steroid?
A: No. It is a non-steroidal immunomodulator that reduces skin inflammation without causing skin thinning.

Q3. How long can I use Advagraf Ointment?
A: It can be used short-term during flare-ups or twice weekly long-term to prevent relapses. Use only under doctor supervision.

Q4. Can it be used on the face?
A: Yes, it is commonly used on sensitive skin areas like the face, neck, and eyelids.

Q5. Is it safe during pregnancy?
A: Use during pregnancy should be limited to when benefits outweigh risks and only under medical advice.

Q6. Can it cause cancer?
A: There is a theoretical risk with prolonged use, though studies have not confirmed a direct causal link. Use with sun protection.
Q7. Can I use makeup or sunscreen after applying the ointment?
A: Yes, once the ointment is fully absorbed. Wait about 1 hour before applying other skin products.
NEJM Study (2001): Tacrolimus 0.1% was as effective as mid-potency corticosteroids for eczema, with fewer long-term side effects.
Cochrane Review (2015): Supported the use of topical calcineurin inhibitors for moderate to severe atopic dermatitis.
AAD Guidelines: Tacrolimus is recommended as a second-line treatment in steroid-refractory or steroid-intolerant eczema.
Advagraf Ointment, Tacrolimus 0.1%, Non-Steroidal Eczema Treatment, Atopic Dermatitis, Skin Immunosuppressant, Sensitive Skin Treatment, Prescription Ointment, Calcineurin Inhibitor, Steroid Alternative, Face Eczema, Topical Anti-inflammatory, EZ Chemist