Altace (Ramipril) – ACE Inhibitor for Hypertension, Heart Failure & Cardiovascular Protection | EZ Chemist Online Pharmacy
Altace (Ramipril Tablets) – Blood Pressure, Heart Failure & Post‑MI Therapy | Buy Online at EZ Chemist
Altace, containing ramipril, is an ACE inhibitor used to treat hypertension, heart failure, and reduce the risk of heart attack, stroke, and cardiovascular death—especially post-myocardial infarction and in high-risk patients—it works by relaxing blood vessels and decreasing blood volume through inhibition of the renin-angiotensin-aldosterone system (RAAS).
DrugBank
Brand Name: Altace
Generic Name: Ramipril
Form: Oral Capsules/Tablets
Strengths: 1.25 mg, 2.5 mg, 5 mg, 10 mg
Mayo Clinic
Drug Class: Angiotensin-Converting Enzyme (ACE) Inhibitor
Prescription Status: Rx only
Manufacturer: Sanofi (branded), various generics
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Ramipril: A pro-drug converted to ramiprilat—an active ACE inhibitor that reduces angiotensin II and increases bradykinin levels.
RxList
Other Brand or Common Names:
Generic: Ramipril
Other brands: Prilace, Ramipro, Triatec, Novapril, Corpril, Cardace, Zigpril, Ramistar
Ramipril inhibits the enzyme ACE, which converts angiotensin I to angiotensin II (a vasoconstrictor), and prevents the breakdown of bradykinin, leading to vasodilation, reduced blood volume, and lowered blood pressure. Enhanced bradykinin also explains the dry cough side effect.
Congestive heart failure (post-MI and chronic)
Post‑myocardial infarction (to reduce mortality)
High cardiovascular risk patients (e.g., diabetics ≥55 years)
Beta-blockers, diuretics, or other ACE inhibitors may be combined where appropriate.
FDA Access Data
Hypertension: 2.5 mg once daily (reduce to 1.25 mg if on diuretics) increasing to 10–20 mg/day single or divided
MedCentral
Heart failure (post‑MI): 2.5 mg every 12 hrs, titrated to 5 mg every 12 hrs
CV risk reduction: 2.5 mg daily ×1 week → 5 mg ×3 weeks → maintain at 10 mg

Renal impairment: Use lower doses (1.25–5 mg/day) and monitor renal function

Administration: Take orally with water. Capsules may be opened and mixed with food or water. Takes weeks for full effect.
Medscape Reference
Headache (≈5%), dizziness, fatigue, dry cough (≈12%), nausea
Serious Adverse Effects:
Hypotension, angioedema (rare but potentially fatal), renal impairment, hyperkalemia, neutropenia, liver dysfunction
Angioedema risk—immediately discontinue if facial/tongue swelling occurs
FDA Access Data
Monitor BP, renal function, electrolytes, especially during initiation or dose changes

Contraindicated with aliskiren in diabetics; avoid during pregnancy and breastfeeding

Use cautiously with diuretics, NSAIDs, and in volume-depleted patients
Diuretics: increased hypotension

Potassium supplements / potassium-sparing agents: risk of hyperkalemia
FDA Access Data

NSAIDs: can impair renal function and reduce hypotensive effect

Lithium: increased lithium levels/toxicity
NCBI

ACE inhibitors or ARBs: do not combine with aliskiren in diabetics; risk of angioedema with ARNI

Gold injections, immunosuppressive agents: rare reactions
MedCentral
Store at room temperature (<30 °C), protect from moisture and light

Keep tightly closed and out of reach of children

Frequently Asked Questions (FAQs):
Q1: What conditions does Altace treat?
It treats high blood pressure, heart failure, post‑MI mortality reduction, and cardiovascular risk in high-risk individuals.
Q2: How long to take before it works?
BP-lowering effects begin within 1–2 weeks; full benefit may take several weeks.
Q3: Why do I have a cough?
Cough results from increased bradykinin, a known ACE inhibitor effect, occurring in ~12% of patients.
Q4: Can I use it during pregnancy?
No. ACE inhibitors cause fetal harm; discontinue before conception.

Q5: Should I take potassium supplements?
Not without medical advice—Altace increases potassium levels, risking hyperkalemia.
Q6: What if I miss a dose?
Take as soon as possible unless it's near the next scheduled dose—do not double the dose.
HOPE Study (NEJM 2000): Reduced cardiovascular events in high-risk patients
AIRE Trial: Reduced mortality post-MI with heart failure
RALES & BENEDICT Studies: Support use in nephropathy and heart failure
Wikipedia

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