Comprehensive Product Description Guide: Ancef Injection (Cefazolin Sodium)
Paired Product Reference: Blackmores Conceive Well Gold 28 Tablets + 28 Capsules
Retailer: EZ Chemist Online Pharmacy
Ancef injection cefazolin, cefazolin sodium injection, surgical antibiotic, injectable cephalosporin antibiotic, EZ Chemist Ancef
What is Ancef used for?
Ancef is a first-generation cephalosporin antibiotic (cefazolin sodium) used to treat bacterial infections and as a prophylactic antibiotic during surgery to prevent infection.
Ancef Injection
Generic Name: Cefazolin Sodium
Form: Powder for reconstitution for intravenous (IV) or intramuscular (IM) injection
Strengths Available: 500 mg, 1 g, 2 g vials
Drug Class: First-generation cephalosporin antibiotic
Schedule: S4 (Prescription Only Medicine – Australia)
Cefazolin sodium (equivalent to cefazolin base)
Ancef

Kefzol (alternative brand name)

Cefazolin

Injectable cephalosporin

Surgical prophylaxis antibiotic
Cefazolin is a bactericidal antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs). This:

Prevents the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls

Causes bacterial cell lysis and death

Effective primarily against Gram-positive cocci and some Gram-negative rods
Preoperative prophylaxis in surgical procedures

Skin and soft tissue infections

Bone and joint infections

Respiratory tract infections (e.g., pneumonia)

Urinary tract infections (UTIs)

Biliary tract infections

Endocarditis prophylaxis

Dosage and Administration:
Administration Route: Intravenous (IV) or intramuscular (IM)
Typical dose: 1–2 g IV preoperatively, then 0.5–1 g every 8 hours postoperatively for 24–48 hours

In infections: 500 mg to 1 g every 6–8 hours depending on severity
25–50 mg/kg/day in 3–4 divided doses, up to 100 mg/kg/day in severe cases
Dosage adjustments are required based on creatinine clearance

Must be reconstituted with sterile water or compatible diluent before administration.
Prescription only (S4 classification)

Not for self-administration — administered in hospitals or clinical settings

Incompatibilities: Avoid mixing with other antibiotics in the same IV line without checking compatibility
Pain at injection site (IM)

Diarrhoea
Nausea or vomiting
Rash or itching
Serious Reactions (rare):
Anaphylaxis (especially in penicillin-allergic patients)
Clostridioides difficile-associated diarrhoea
Neutropenia, thrombocytopenia
Elevated liver enzymes
Allergy alert: Cross-reactivity in those allergic to penicillins

Renal impairment: Adjust dose to avoid drug accumulation

Superinfection risk: Prolonged use may cause fungal or resistant bacterial overgrowth

Not effective for viral infections

Pregnancy Category B1 (AU): No evidence of fetal harm; often used in C-section prophylaxis
Increased Risk or Altered Efficacy With:

Aminoglycosides: Increased risk of nephrotoxicity

Probenecid: May increase cefazolin serum concentration

Anticoagulants (e.g., warfarin): May enhance effects – monitor INR

Oral contraceptives: Minimal interaction, but backup methods advised with prolonged use
No direct interaction; however, spacing of administration is not needed since Ancef is parenteral

Safe when used under medical supervision in perinatal settings
Pharmacologic Class: Cephalosporin antibiotic (1st generation)

Therapeutic Class: Antibacterial

ATC Code: J01DB04

Regulatory Status: Schedule 4 (Prescription Medicine – Australia)

Frequently Asked Questions (FAQs):
Q1. What infections does Ancef treat?
A: Ancef is used to treat bacterial infections of the skin, lungs, urinary tract, and is widely used in surgical infection prevention.

Q2. Can I take Ancef if allergic to penicillin?
A: Not recommended unless confirmed safe by an allergist; up to 10% cross-reactivity exists with penicillin.

Q3. How is Ancef administered?
A: Administered intravenously or intramuscularly by healthcare professionals.

Q4. Is Ancef safe during pregnancy?
A: Yes, commonly used during labor, C-sections, and perinatal infections. Always follow doctor’s advice.

Q5. How long does it take to work?
A: Starts working within 1–2 hours of IV administration. Full course depends on infection type and severity.
Standard prophylactic agent in orthopaedic, cardiovascular, and obstetric surgeries

Lower infection rates observed in pre-op patients receiving Ancef vs placebo (JAMA Surg, 2015)

Excellent tissue penetration and half-life (~1.5–2 hrs), allowing effective dosing intervals
Store below 25°C

Protect reconstituted solution from light
Discard unused portion within 24 hours after reconstitution (or as per manufacturer)

Do not freeze reconstituted solutions
Buy Ancef Injection (Cefazolin Sodium) Online
Available at: EZ Chemist Online Pharmacy (Insert direct product URL when published)
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