Androxal (Enclomiphene Citrate) – Oral SERM for Male Secondary Hypogonadism | EZ Chemist Online Pharmacy
Androxal Enclomiphene Citrate – Oral Therapy for Low Testosterone & Fertility Preservation | Buy Online at EZ Chemist
What is Androxal used for?
Androxal (enclomiphene citrate) is an oral selective estrogen receptor modulator (SERM) designed to treat male secondary hypogonadism by increasing endogenous testosterone, luteinising hormone (LH), and follicle-stimulating hormone (FSH), while preserving sperm production—unlike exogenous testosterone therapy.
Fierce Biotech
Brand Name: Androxal
Generic Name: Enclomiphene Citrate

Form: Oral tablet or capsule
Typical Strengths: 6.25 mg, 12.5 mg, 25 mg daily
Drug Class: SERM (Selective Estrogen Receptor Modulator); progonadotropin
Prescription Status: Investigational/unapproved by FDA; available via compounding with prescription
Availability: Compounding pharmacies in India with doctor’s prescription

Manufacturer: Originally developed by Repros Therapeutics
Active Ingredient: Enclomiphene citrate (the E-isomer of clomiphene citrate)
MedPath
Common Names: Androxal, Enclomid, (E)-Clomifene, RMI-16289
Related Compounds: Part of clomiphene citrate mixture (combines enclomiphene & zuclomiphene)

Enclomiphene acts as an estrogen receptor antagonist at the hypothalamic-pituitary axis. It blocks negative estrogen feedback, increasing gonadotropin (LH & FSH) secretion and stimulating endogenous testosterone production, while maintaining spermatogenesis.
Male secondary hypogonadism (low testosterone with low/inappropriately normal LH/FSH)

Fertility preservation treatment in hypogonadal men

Alternative to testosterone replacement therapy due to maintained sperm production

Under investigation for idiopathic infertility
PMC
Dose Range Typical Dose Frequency
Oral capsules 6.25 mg – 25 mg daily Once daily (AM)

Initial dose often 12.5 mg/day, titrated based on testosterone response

Morning administration recommended
Continue for 6–12 weeks, with periodic monitoring
Pharmacology
Absorption & Onset: Increases testosterone and LH within ~2 weeks; stable serum levels sustained with daily dosing
Half-life: Approximately 10 hours; pure E-isomer offers more predictable pharmacokinetics compared to clomiphene
CareFirst Specialty Pharmacy
Metabolism: Via CYP2D6 and CYP3A4 in the liver
Safety Information & Side-Effects
Common Side Effects
Headache, hot flashes, nausea, mild abdominal discomfort
CareFirst Specialty Pharmacy
Slightly increased risk of venous thromboembolism (SERM class)

Visual disturbances (blurriness, photophobia) – uncommon, reversible
precisionFDA
Rare hormonal side effects such as mood swings or libido changes

Warnings & Precautions
Not FDA-approved: Use under physician supervision only
Contraindications: Known estrogen-sensitivity, history of thrombosis or thromboembolic disorders
Avoid use in women – may cause ovarian hyperstimulation
Regular monitoring: serum testosterone, LH/FSH, liver enzymes, visual assessments during long-term use
Metabolized by CYP2D6 and CYP3A4 – potential interaction with inhibitors/inducers of these enzymes
No strong direct interactions reported, but caution when combined with other hormonal treatments or anticoagulants (due to thrombosis risk)
Frequently Asked Questions (FAQs)
Q1: Is Androxal FDA-approved?
No. Androxal has not received FDA approval but is available legally through compounding pharmacies with a valid prescription

Q2: How does it differ from testosterone gel (e.g., AndroGel)?
Unlike testosterone therapy that suppresses sperm production, Androxal increases endogenous testosterone while preserving fertility
Q3: How quickly does it work?
Serum testosterone and LH levels typically rise within 2 weeks, with sustained normalization over 6+ weeks .

Q4: Can it improve fertility?
Clinical studies show that Androxal maintains or improves sperm count, whereas exogenous testosterone often suppresses it
Q5: What dose should be used?
Doses commonly range from 6.25 mg to 25 mg once daily, adjusted based on hormone response and tolerability.

Q6: Is it safe long-term?
Long-term safety still under study. Monitor for possible visual issues, mood changes, and thromboembolic risk. Use only under medical supervision.

Clinical Evidence & References
Wiehle et al. (2013): Enclomiphene vs transdermal testosterone in men with secondary hypogonadism showed sustained LH, FSH, and maintained sperm count
Phase III trials: Androxal met primary endpoints in testosterone normalization and sperm concentration vs topical testosterone
Expert Review (2016): SERM benefits in male hypogonadism
Buy Androxal (Compounding) – EZ Chemist
You can order Androxal (Enclomiphene Citrate 12.5/25 mg) through our certified compounding pharmacy. Ideal for men with secondary hypogonadism seeking fertility-compatible testosterone normalization. Requires valid prescription
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