Anizone S Injection (Ampicillin / Sulbactam)
Compared with: Blackmores Conceive Well Gold 28 Tablets + 28 Capsules

Anizone S Injection combines a broad‑spectrum penicillin (ampicillin) with a β‑lactamase inhibitor (sulbactam) to overcome bacterial resistance. Administered intravenously or intramuscularly, it treats serious Gram‑positive and Gram‑negative infections, including skin, respiratory, intra‑abdominal, and gynecological infections. Anizone S is effective where ampicillin alone fails.
Ampicillin Sodium – 1 g per vial
Sulbactam Sodium – 0.5 g per vial
Other Popular and Common Names
Ampicillin/Sulbactam Injection
Unasyn® (brand equivalent)
β‑Lactam/β‑Lactamase Inhibitor Combination
Broad‑Spectrum Antibiotic IV/IM
Ampicillin inhibits bacterial cell‑wall synthesis by binding penicillin‑binding proteins (PBPs).
Sulbactam irreversibly inactivates β‑lactamases, protecting ampicillin from enzymatic degradation and extending its spectrum to β‑lactamase–producing organisms.
Anizone S is indicated for management of moderate to severe infections caused by susceptible organisms, including:
Skin and Soft Tissue Infections (e.g., cellulitis, abscess)
Lower Respiratory Tract Infections (e.g., pneumonia, bronchitis)
Intra‑Abdominal Infections (e.g., peritonitis, appendicitis)
Gynecological Infections (e.g., endometritis, pelvic inflammatory disease)
Urinary Tract Infections (complicated pyelonephritis)
Septicemia and Bone and Joint Infections (adjunctive therapy)
Patient Group Dose Frequency Route
Adults 1.5–3 g per dose (ampicillin 1 g–2 g/sulbactam 0.5 g–1 g) Every 6 hours IV infusion over 15–30 minutes or IM
Children (>2 months) 100 mg/kg per day (ampicillin component) divided every 6 h Every 6 hours IV/IM, adjust per weight
Renal Impairment Adjust dose and/or interval based on creatinine clearance
Reconstitution: Dissolve in 10–20 mL sterile water for injection; further dilute appropriately for IV infusion.
Infusion: Over 15–30 minutes to reduce local irritation; flush line before and after with saline.
Formulation: Lyophilized powder for injection

Strength: 1.5 g vial (1 g ampicillin + 0.5 g sulbactam)
Route: Intravenous, Intramuscular
Legal Status: Prescription Only Medicine
Pregnancy: Category B – No evidence of human risk; use only if clearly needed.

Breastfeeding: Excreted in breast milk; monitor infant for diarrhea or rash.

Neonates: Use with caution; adjust dose for premature infants and those with immature renal function.

Renal Impairment: Dose adjust for creatinine clearance <30 mL/min; monitor renal function.
Injection‑site pain or phlebitis
Diarrhea, nausea, vomiting
Rash (non‑allergic)
Hypersensitivity reactions (anaphylaxis, urticaria)
Clostridioides difficile–associated diarrhea
Hematologic changes (neutropenia, thrombocytopenia)
Seizures with high doses or severe renal impairment
Allergy Alert: Contraindicated in patients with a history of penicillin or β‑lactam allergy.

Superinfection: Prolonged use may lead to fungal or bacterial superinfections.

Neurotoxicity: High plasma levels in renal failure can precipitate seizures.

Electrolyte Monitoring: Monitor sodium load in those on fluid restriction or heart failure.

Therapeutic Class: Antibiotic Combination

Pharmacologic Class: β‑Lactam/β‑Lactamase Inhibitor

Legal Category: Prescription Only
Allopurinol: Increased risk of rash.

Methotrexate: Reduced clearance of methotrexate; monitor toxicity.

Probenecid: Inhibits renal tubular secretion of ampicillin; increases and prolongs plasma levels.

Aminoglycosides: May be mixed in the same infusion fluid for synergistic effect, but administer separately to avoid chemical incompatibility.
Comparative trials demonstrate ampicillin/sulbactam superiority over ampicillin alone in β‑lactamase–producing infections, with clinical cure rates >85 % in intra‑abdominal and skin‑structure infections (Darland et al., Antimicrob Agents Chemother, 1985).
Comparison with Blackmores Conceive Well Gold
Anizone S Injection treats acute bacterial infections requiring parenteral therapy, while Blackmores Conceive Well Gold supports preconception nutrition. Women receiving Anizone S for gynecological or intra‑abdominal infections should complete antibiotic therapy and confirm infection resolution before conceiving, then transition to Conceive Well Gold for optimized fertility support.
FAQs – Anizone S Injection (Ampicillin/Sulbactam)
Q1. How soon will I feel better?
A: Clinical improvement often occurs within 48–72 hours; completion of the prescribed course is essential for eradication.

Q2. Can I receive it intramuscularly?
A: Yes. IM injection is an alternative when IV access is not feasible; rotate sites to minimize local irritation.

Q3. What precautions are needed for penicillin allergies?
A: Contraindicated if a history of anaphylaxis or severe penicillin reaction; consider an alternative antibiotic class.

Q4. Is monitoring required?
A: Monitor renal function, complete blood count, and signs of superinfection during prolonged therapy.

Q5. Can it be used in children?
A: Yes, with weight‑based dosing; avoid in neonates without specialist guidance.

Q6. How should I store unused solution?
A: Use reconstituted solution immediately; if necessary, store diluted infusion under refrigeration (2–8 °C) and use within 24 hours.

Q7. Can Anizone S treat urinary tract infections?
A: Yes, complicated UTIs caused by susceptible organisms respond well to this combination.
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