Artane (Trihexyphenidyl) – Anticholinergic Therapy for Parkinson’s Disease & Drug-Induced Movement Disorders | Buy Online at EZ Chemist
Artane (Trihexyphenidyl HCl) Tablets – Parkinson’s Tremor Control & EPS Treatment | Buy Online from EZ Chemist

Artane (Trihexyphenidyl Hydrochloride) is an anticholinergic medication used to treat Parkinson’s disease and to control extrapyramidal symptoms (EPS) caused by antipsychotic medications. It reduces muscle stiffness, tremors, and uncontrolled movements by restoring the balance of neurotransmitters in the brain.
Brand Name: Artane

Generic Name: Trihexyphenidyl Hydrochloride

Formulation: Oral tablets

Strengths Available: 2 mg, 5 mg

Route of Administration: Oral

Therapeutic Class: Anticholinergic / Antiparkinsonian

Prescription Status: Prescription-only medicine (Rx)
Trihexyphenidyl Hydrochloride
Trihexyphenidyl

Benzhexol Hydrochloride (alternative name)

Anticholinergic Parkinson’s Medicine

EPS Control Tablet

Parkinson Tremor Relief Tablet
Artane acts as a central anticholinergic agent by blocking muscarinic receptors in the brain, thereby reducing acetylcholine activity. Parkinson’s disease involves a dopamine-acetylcholine imbalance, and by lowering acetylcholine, Artane helps restore balance, leading to improved motor control, reduced tremor, and decreased rigidity.

In drug-induced extrapyramidal symptoms (EPS), Artane counteracts the cholinergic overactivity caused by antipsychotic-induced dopamine blockade.
Parkinson’s disease (idiopathic and post-encephalitic)

Extrapyramidal symptoms (EPS) caused by antipsychotic medications

Parkinsonian tremor and muscle rigidity

Adjunct in other movement disorders including dystonia and akathisia
Indication Starting Dose Maintenance Dose
Parkinson’s Disease 1 mg orally daily Titrated up to 6–10 mg/day in divided doses
Drug-Induced EPS 1–2 mg 1–2 times/day Up to 15 mg/day depending on severity

Administration: Take with meals to minimize gastrointestinal discomfort

Adjustment: Start low and titrate slowly based on response and tolerance

Elderly: Use lowest effective dose to avoid confusion or hallucinations
Start with low doses, increase gradually

Optimal dosing varies between individuals

Discontinuation should be gradual to avoid rebound symptoms

May be used in combination with levodopa or other antiparkinsonian drugs
Dry mouth

Blurred vision

Drowsiness

Constipation

Dizziness

Urinary retention
Confusion, memory loss (especially in elderly)

Hallucinations

Tachycardia

Glaucoma exacerbation

Heat intolerance or hyperthermia
Not recommended in children under 3 years

Use with caution in patients with prostatic hypertrophy, cardiac disease, or gastrointestinal obstruction

May cause cognitive impairment in elderly

Avoid use in angle-closure glaucoma

Use cautiously in hot environments due to impaired sweating
Anticholinergic / Antiparkinsonian Agent

Schedule H drug in India – requires a valid prescription
Interacting Drug/Class Effect
Levodopa May enhance therapeutic effect but also adverse reactions
Antipsychotics (e.g., haloperidol, risperidone) Reduces EPS symptoms
Antihistamines / Tricyclic Antidepressants Additive anticholinergic side effects
Alcohol & CNS depressants Increased sedation risk
MAO Inhibitors Use cautiously – monitor for agitation/confusion

Avoid combining with other anticholinergics unless clinically justified.

Clinical Evidence and Efficacy
Studies have shown that trihexyphenidyl significantly reduces tremors and rigidity in Parkinson’s patients, especially in younger individuals.

In drug-induced parkinsonism, a review by the British Journal of Psychiatry (2004) confirmed trihexyphenidyl's role in controlling EPS symptoms effectively.

Often preferred in early-stage Parkinson’s or tremor-dominant types.

Frequently Asked Questions (FAQs)
Q1: Is Artane a cure for Parkinson’s disease?
No, Artane does not cure Parkinson’s. It manages symptoms like tremors, stiffness, and movement difficulty.

Q2: Can Artane be used with Levodopa?
Yes, it can be used alongside levodopa and other antiparkinson drugs for enhanced symptom control.

Q3: Is Artane safe for elderly patients?
Use with caution. It may cause confusion, memory problems, or hallucinations, especially in older adults.

Q4: What should I do if I miss a dose?
Take the missed dose as soon as possible. If it’s near the next dose time, skip it—do not double the dose.

Q5: Can I drink alcohol while on Artane?
Avoid alcohol as it may increase drowsiness and dizziness.

Q6: How long does Artane take to show effects?
Initial improvement is often seen within a few days; full effect develops over 1–2 weeks of consistent use.

Buy Artane (Trihexyphenidyl Hydrochloride) – EZ Chemist
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