Comprehensive Product Description Guide: Asendin (Amoxapine)
With Reference to: Blackmores Conceive Well Gold 28 Tablets + 28 Capsules
Asendin Amoxapine antidepressant, tricyclic antidepressant, major depressive disorder, TCA medication, EZ Chemist mental health

Asendin (Amoxapine) is a tricyclic antidepressant (TCA) used to treat major depressive disorder and depression with anxiety by increasing the levels of norepinephrine and serotonin in the brain.
Asendin
Generic Name: Amoxapine
Strength: 25 mg / 50 mg / 100 mg (available strengths)
Form: Oral tablet
Drug Class: Tricyclic Antidepressant (TCA)
Amoxapine

Asendin generic

Tricyclic antidepressant

Mood stabiliser

Depression and anxiety medication

Active Ingredient
Amoxapine – A tricyclic antidepressant with dual norepinephrine and serotonin reuptake inhibition and additional dopamine receptor antagonist activity.
Amoxapine works by:

Inhibiting reuptake of norepinephrine and serotonin in the central nervous system, increasing their levels in the synaptic cleft

Blocking dopaminergic receptors (D2), offering mild antipsychotic properties

Stabilising mood and improving depressive symptoms, particularly where anxiety or psychotic features are present

Its dopaminergic antagonism makes it distinct from other TCAs and closer to a bridging agent between antidepressants and antipsychotics.
Major depressive disorder (MDD)

Depression associated with anxiety or agitation

Treatment-resistant depression

Off-label: May be considered in bipolar depression (with caution) and schizoaffective disorder adjunctively
Adult Dose (General):

Initial: 50 mg–100 mg/day, divided or at bedtime

Maintenance: 200–300 mg/day (maximum: 400 mg/day)

Elderly or debilitated patients: Begin at 25–50 mg/day

Tablets should be swallowed whole with water. Do not crush or chew. May be taken with or without food.

Prescribing and Monitoring
Prescription-only medicine

Gradual dose titration recommended

Monitor suicidal ideation, especially in young adults

Baseline and periodic ECG monitoring advised due to TCA’s risk of QT prolongation

Regular liver function, renal function, and blood count monitoring in long-term use
Common Side Effects
Dry mouth

Drowsiness or sedation

Constipation

Dizziness

Weight gain

Blurred vision

Serious Side Effects
Seizures (dose-related)

Extrapyramidal symptoms (due to dopamine receptor blockade)

Tardive dyskinesia (rare)

Neuroleptic malignant syndrome

QT interval prolongation and cardiac arrhythmias

Suicidal ideation (especially in <25 years)
Not suitable for use in children under 18 years

Caution in patients with a history of seizures, cardiovascular disease, liver/kidney impairment

Avoid in combination with monoamine oxidase inhibitors (MAOIs) – requires 14-day washout

May impair driving or operating machinery

May increase risk of falls in elderly

Do not use during pregnancy or breastfeeding unless benefits outweigh risks
MAO inhibitors (e.g., phenelzine, selegiline)

SSRIs (e.g., fluoxetine, sertraline) – risk of serotonin syndrom
CNS depressants – enhances sedative effects

Anticholinergic drugs – increases side effects (e.g., dry mouth, constipation)

Alcohol – potentiate CNS depression

Blackmores Conceive Well Gold – not recommended during antidepressant therapy or in patients with untreated depression/anxiety planning conception
Pharmacological Class: Tricyclic Antidepressant

ATC Code: N06AA17

Schedule: Schedule 4 (Prescription only)

Pregnancy Category: C – Use with caution

Therapeutic Class: Antidepressant

Clinical Evidence and Efficacy
Studies (Journal of Clinical Psychiatry, 1980s–1990s) showed comparable efficacy to other TCAs (e.g., amitriptyline) with faster onset of action in some cases

Effective in depression with psychotic features and agitation

Demonstrated mild antipsychotic effects at higher doses due to dopamine antagonism

Less sedating than amitriptyline but more likely to cause extrapyramidal symptoms
Store below 25°C

Keep away from light and moisture

Do not use expired tablets

Keep out of reach of children
Q1. Is Asendin the same as amoxapine?
Yes, Asendin is the brand name for amoxapine, a tricyclic antidepressant used to treat major depression, particularly with anxious or agitated features.

Q2. Can I take Asendin with Blackmores Conceive Well Gold?
No. Asendin is not recommended during pregnancy or pre-conception planning due to potential effects on the fetus. Discuss alternative options with your doctor.

Q3. Is Asendin safe for elderly patients?
Use with caution. Start at low doses to avoid sedation, dizziness, falls, and cardiac complications. Monitor regularly.

Q4. How long does Asendin take to work?
Most patients notice improvements within 1–2 weeks, with full effects evident after 4–6 weeks of consistent use.

Q5. Can Asendin cause withdrawal symptoms?
Yes. Do not stop abruptly. Gradual tapering is required to avoid withdrawal effects such as anxiety, insomnia, and flu-like symptoms.

Buy Asendin (Amoxapine) Online
Available at: EZ Chemist Online Pharmacy (Insert live link when available)
Asendin, Amoxapine, Tricyclic Antidepressant, Major Depressive Disorder, Anxiety Relief, Prescription, Mood Stabiliser, TCA Class, EZ Chemist