Augmentin Injection (Amoxicillin + Clavulanic Acid) – Broad-Spectrum IV Antibiotic | Buy Online at EZ Chemist
Augmentin Injection 1.2g (Amoxicillin and Clavulanic Acid) – IV Antibiotic for Severe Infections | Order from EZ Chemist
What is Augmentin Injection used for?
Augmentin Injection is a combination of amoxicillin and clavulanic acid, used to treat a wide range of moderate to severe bacterial infections including respiratory, urinary, abdominal, and skin infections. Administered via IV or IM, it works by killing bacteria and preventing resistance.
Brand Name: Augmentin

Generic Name: Amoxicillin Sodium + Clavulanate Potassium

Formulation: Powder for Injection
1.2g (Amoxicillin 1g + Clavulanic acid 200mg)
600mg (Amoxicillin 500mg + Clavulanic acid 100mg)
Route of Administration: Intravenous (IV) or Intramuscular (IM)
Therapeutic Class: Beta-lactam/beta-lactamase inhibitor combination

Prescription Status: Schedule H (Prescription only)
Amoxicillin Sodium (Penicillin-class antibiotic)
Clavulanate Potassium (Beta-lactamase inhibitor)
Co-amoxiclav Injection

Amoxicillin-Clavulanic Acid IV

Augmentin IV/IM

Broad-spectrum penicillin injection

Beta-lactamase-resistant penicillin
Amoxicillin interferes with bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), causing cell lysis.

Clavulanic acid inhibits beta-lactamase enzymes produced by resistant bacteria, protecting amoxicillin from degradation.

This synergistic action expands coverage to beta-lactamase-producing organisms.
Augmentin injection is indicated for the treatment of moderate to severe infections, including:

Lower respiratory tract infections (e.g., pneumonia, bronchitis)

Urinary tract infections (UTIs)

Intra-abdominal infections (e.g., peritonitis, abscesses)

Skin and soft tissue infections (e.g., cellulitis, abscesses)

Bone and joint infections (e.g., osteomyelitis)

Gynaecological infections (e.g., pelvic inflammatory disease)

Dental infections requiring parenteral antibiotics

Septicemia or post-operative infections
Age Group Strength Route Frequency
Adults & Children >12 yrs 1.2g IV/IM Every 8 hours (q8h)
Children (3 months–12 years) 30mg/kg IV Every 8 hours
Neonates & Infants <3 months 30mg/kg IV Every 12 hours

Duration: Typically 5–14 days depending on infection severity and clinical response

Preparation: Reconstitute with sterile water before use

IV infusion: Administer over 30–40 minutes

IM injection: Deep gluteal muscle only

Note: Dosage must be adjusted in renal impairment.
Use in confirmed or suspected bacterial infections

Initiate after susceptibility testing where available

Complete full course even if symptoms improve early

Switch to oral Augmentin tablets/suspension once clinically stable
Nausea

Diarrhoea

Injection site pain or phlebitis

Skin rash

Headache
Anaphylaxis or severe hypersensitivity reactions

Clostridioides difficile–associated diarrhea

Hepatic dysfunction (elevated liver enzymes, cholestasis)

Seizures in high IV doses or renal impairment
Penicillin allergy: Contraindicated in patients with a history of penicillin or cephalosporin allergy

Use caution in patients with hepatic disease, renal dysfunction, or mononucleosis

Monitor renal and liver function with prolonged use

Avoid in neonates unless benefits outweigh risks

Not suitable for treating viral infections (e.g., cold, flu)
Pharmacological Class: Penicillin-class β-lactam antibiotic with β-lactamase inhibitor

Schedule H drug under Indian regulations (Prescription only)
Interacting Drug Effect
Allopurinol ↑ Risk of skin rash
Warfarin & Anticoagulants ↑ INR; monitor coagulation
Methotrexate ↓ Methotrexate clearance; monitor toxicity
Probenecid ↑ Amoxicillin levels
Oral contraceptives ↓ Effectiveness; recommend additional contraception
A meta-analysis published in The Lancet Infectious Diseases supports Augmentin's superior efficacy over amoxicillin alone in treating resistant respiratory tract infections.

Clavulanic acid increases the spectrum and clinical cure rate by approximately 15–25% in penicillinase-producing organisms.

WHO & CDC list co-amoxiclav as first-line therapy in many community-acquired infections.

Frequently Asked Questions (FAQs)
Q1: What is Augmentin Injection used for?
It is used to treat a wide range of moderate to severe infections caused by susceptible bacteria, especially when oral therapy is not possible.

Q2: Can Augmentin be given to children?
Yes, dosage is based on body weight and adjusted according to age and renal function.

Q3: What should be done if a patient develops diarrhea while on Augmentin?
Discontinue the injection if diarrhea is severe or persistent, and investigate for possible Clostridium difficile infection.

Q4: How is Augmentin different from amoxicillin alone?
It contains clavulanic acid which protects amoxicillin from beta-lactamase–producing bacteria, making it effective against more resistant strains.

Q5: Can it be used in pregnancy?
Yes, Augmentin is generally considered safe in pregnancy (Category B) but should be used under physician supervision.

Q6: How should Augmentin Injection be stored?
Store the dry powder below 25°C. Reconstituted solution should be used within 20 minutes of preparation or per label directions.
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