Augmentin® Syrup (Amoxicillin / Clavulanate Oral Suspension)
Compared with: Blackmores Conceive Well Gold 28 Tablets + 28 Capsules

Augmentin® Syrup combines amoxicillin with clavulanic acid to overcome β‑lactamase–producing bacteria, offering broad‑spectrum coverage for pediatric and adult respiratory, ear, skin, and urinary tract infections. Its palatable oral suspension ensures accurate dosing and compliance in children.
Amoxicillin Trihydrate – 200 mg per 5 mL
Clavulanic Acid Potassium – 28.5 mg per 5 mL
Other Popular and Common Names
Co‑amoxiclav
Amoxicillin + Clavulanate Potassium
Clavulin® (alternate brand)
Synulox® (veterinary analog)
Amoxicillin: Inhibits bacterial cell‑wall synthesis by binding penicillin‑binding proteins (PBPs).

Clavulanic Acid: Irreversibly inhibits β‑lactamases, protecting amoxicillin from enzymatic degradation and extending its spectrum to resistant organisms.
Together, they provide synergistic bactericidal activity against Gram‑positive, Gram‑negative, and β‑lactamase–producing strains.
Acute Otitis Media

Sinusitis (acute bacterial)

Pharyngitis / Tonsillitis

Acute Bacterial Bronchitis

Skin and Soft Tissue Infections

Urinary Tract Infections (uncomplicated)

Dental Infections requiring broad‑spectrum coverage
Age / Weight Group Dose Frequency Duration
Children ≥2 months 45 mg/kg/day amoxicillin component Divided every 12 h 5–7 days (standard)
(7.2 mL per dose)
Severe Infections 70 mg/kg/day amoxicillin component Divided every 8 h 7–10 days
Adults and Adolescents 500 mg/125 mg per 5 mL equivalent 7.5 mL every 12 h 5–10 days
Preparation: Shake bottle well before use. Measure with a calibrated spoon or syringe.
Administration: Can be taken with or without food; with food reduces gastrointestinal upset.
Missed Dose: Administer as soon as possible, then resume schedule; do not double doses.
Formulation: Powder for reconstitution to oral suspension
Strength: 200 mg / 5 mL amoxicillin + 28.5 mg / 5 mL clavulanate
Route: Oral
Legal Status: Prescription Only Medicine
Pregnancy: Category B – Use only if clearly needed; amoxicillin is well‑studied, clavulanate crosses placenta minimally.

Breastfeeding: Excreted in breast milk in low levels; monitor infant for diarrhea or candidiasis.

Children <2 months: Use only under specialist supervision.

Renal Impairment: Dose adjustment required if creatinine clearance <30 mL/min.
Diarrhea, nausea, vomiting
Rash (non‑allergic)
Oral or vaginal candidiasis
Severe hypersensitivity (anaphylaxis)
Clostridioides difficile–associated diarrhea
Hepatotoxicity (cholestatic jaundice)
Hematologic abnormalities (neutropenia, thrombocytopenia)
Allergy Alert: Contraindicated in penicillin or clavulanate hypersensitivity; cross‑reactivity with cephalosporins possible.

Superinfection: May cause overgrowth of non‑susceptible organisms (e.g., Candida).

Diarrhea: If severe or bloody, discontinue and evaluate for C. difficile.

Liver Dysfunction: Use cautiously in hepatic impairment; monitor liver enzymes if therapy exceeds 14 days.
Therapeutic Class: Antibiotic Combination

Pharmacologic Class: Aminopenicillin + β‑Lactamase Inhibitor

Legal Category: Prescription Only
Allopurinol: Increased rash incidence.
Oral Contraceptives: Diarrhea may reduce absorption; consider backup contraceptive methods during therapy.
Probenecid: Decreases renal excretion of amoxicillin; increases serum levels.
Methotrexate: May reduce clearance; monitor for toxicity.
Warfarin: Antibiotic‑associated alterations in vitamin K–producing flora may affect INR; monitor coagulation.
Studies demonstrate that co‑amoxiclav achieves clinical cure rates >90 % in pediatric otitis media compared to amoxicillin alone.
Meta‑analyses confirm superiority of the combination in β‑lactamase–producing pathogen infections.
FAQs – Augmentin® Syrup (Amoxicillin / Clavulanate)
Q1. Why use Augmentin instead of amoxicillin alone?
A: Clavulanate inhibits bacterial β‑lactamases, restoring amoxicillin activity against resistant strains.

Q2. Can Augmentin cause diarrhea?
A: Yes. Take with food and maintain hydration; if severe, consult your physician regarding C. difficile.

Q3. Is it safe for ear infections in toddlers?
A: Yes. Standard pediatric dosing of 45 mg/kg/day provides effective coverage for acute otitis media.

Q4. How long is the syrup stable after reconstitution?
A: Store refrigerated and use within 7–10 days per manufacturer instructions.

Q5. Can I give Augmentin with my child’s multivitamin?
A: It is generally safe; administer doses spaced by at least 1 hour to avoid dilution effects.

Q6. What if my child vomits after a dose?
A: If vomiting occurs within 30 minutes of dosing, repeat the dose; otherwise, proceed to next scheduled dose.

Q7. Can adults use Augmentin syrup?
A: Adults typically use tablet formulations; syrup is reserved for those unable to swallow or for pediatric use.
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