Avalide (Irbesartan + Hydrochlorothiazide) – Combination Therapy for Hypertension | Buy Online at EZ Chemist
Avalide Tablets – Irbesartan and Hydrochlorothiazide Combination for High Blood Pressure | Order from EZ Chemist Pharmacy
What is Avalide used for?
Avalide is a fixed-dose combination of irbesartan, an angiotensin II receptor blocker (ARB), and hydrochlorothiazide, a thiazide diuretic. It is used to treat high blood pressure (hypertension), particularly in patients not adequately controlled on monotherapy. It helps reduce the risk of stroke and heart attack by lowering blood pressure.
Brand Name: Avalide

Generic Name: Irbesartan + Hydrochlorothiazide

Dosage Form: Oral tablet
Irbesartan 150 mg + Hydrochlorothiazide 12.5 mg

Irbesartan 300 mg + Hydrochlorothiazide 12.5 mg

Irbesartan: Angiotensin II Receptor Blocker (ARB)

Hydrochlorothiazide: Thiazide diuretic

Prescription Status: Prescription-only (Schedule H in India)
Irbesartan – ARB that blocks the vasoconstricting and aldosterone-secreting effects of angiotensin II

Hydrochlorothiazide (HCTZ) – Diuretic that helps eliminate excess sodium and water, reducing blood volume and pressure

Other Popular and Common Names
Generic Irbesartan + HCTZ

Angiotensin II antagonist with diuretic

Co-Irbesartan

ARB/diuretic combination tablet
Irbesartan selectively blocks angiotensin II from binding to its AT1 receptor, leading to vasodilation, reduced aldosterone secretion, and decreased blood pressure.

Hydrochlorothiazide increases renal excretion of sodium and water by inhibiting reabsorption in the distal tubules, lowering blood volume and vascular resistance.

The dual mechanism provides additive antihypertensive effects, especially in salt-sensitive or volume-overloaded individuals.
Hypertension (essential) not adequately controlled with monotherapy

Initial therapy in patients likely to need multiple drugs

Cardiovascular risk reduction by controlling elevated BP

Renal protection in hypertensive patients with type 2 diabetes (off-label use for combination)
Patient Group Initial Dose Maintenance Dose Maximum Dose
Adults 150/12.5 mg once daily 150/12.5 mg or 300/12.5 mg 300/25 mg (off-label, based on component titration)

Administration: Oral, once daily with or without food

Adjustments: Based on BP response after 2–4 weeks

Not for use in: Severe renal or hepatic impairment without specialist consultation
Do not use if patient is pregnant or planning pregnancy

Use with caution in volume-depleted patients or those on diuretics

Monitor serum electrolytes (Na⁺, K⁺) and renal function (eGFR, creatinine) regularly

Adjust dosage in elderly or renal-impaired patients

Do not administer with aliskiren in diabetics (contraindicated)
Dizziness

Fatigue

Nausea

Muscle cramps

Headache

Increased urination

Serious Adverse Reactions
Hypokalemia or hyperkalemia

Acute renal failure (especially in volume-depleted individuals)

Hypotension (especially in sodium-depleted states)

Stevens-Johnson Syndrome (rare)

Electrolyte disturbances (Na⁺, K⁺, Cl⁻)
Pregnancy Category D: Contraindicated during second and third trimesters – may cause fetal injury or death

Breastfeeding: Not recommended

Renal impairment: Avoid if eGFR <30 mL/min/1.73 m²

Hepatic impairment: Use with caution

Electrolyte imbalance: Regular monitoring essential

Avoid NSAIDs due to potential risk of renal impairment
ATC Code: C09DA04

Pharmacologic Category: Antihypertensive / ARB with diuretic

Schedule H Drug (India) – Prescription required
Drug/Class Effect
NSAIDs May reduce antihypertensive efficacy; risk of renal impairment
Lithium Increased lithium levels/toxicity
Potassium supplements / K⁺ sparing diuretics Risk of hyperkalemia
Diabetes medications May enhance hypoglycemic effect
Alcohol or barbiturates May increase orthostatic hypotension
Corticosteroids Risk of hypokalemia when combined with HCTZ

Clinical Studies and Data
In a 12-week double-blind study (Hypertension, 2003), Avalide 150/12.5 mg achieved significantly greater systolic and diastolic BP reductions compared to monotherapy of either agent.

The proportion of patients achieving BP goals (<140/90 mmHg) was higher with the combination therapy (up to 70%).

Combination therapy improved arterial stiffness markers and LV mass index in patients with stage 2 hypertension.

Frequently Asked Questions (FAQs)
Q1: What is Avalide used for?
Avalide is used for treating high blood pressure, particularly in people who require more than one medication to control it.

Q2: Can Avalide be taken with food?
Yes, Avalide can be taken with or without food.

Q3: Is Avalide suitable for diabetics?
Yes, but caution is advised. Monitor blood glucose and kidney function regularly. Avoid combining with aliskiren in diabetics.

Q4: Can it be used during pregnancy?
No. Avalide is contraindicated in pregnancy, especially during the second and third trimesters due to fetal toxicity risks.

Q5: How quickly does Avalide lower blood pressure?
Initial effects are seen within 1–2 weeks, with full blood pressure control achieved within 4–6 weeks.

Q6: Can I stop Avalide suddenly?
No. Stopping abruptly may cause rebound hypertension. Consult your doctor before discontinuing.

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