Avène Cleanance Comédomed Anti‑Blemishes Concentrate 30 ml
A lightweight, non-greasy gel-moisturiser designed for acne-prone, oily, and sensitive skin (ages 12+). Powered by 25% Comedoclastin™, a patented milk thistle-derived active that reduces existing imperfections and prevents new ones within 7 days. Clinically proven, high tolerance, fragrance-free — safe during pregnancy.

Cleanance Comédomed is a fast-absorbing, fragrance-free concentrate with 25% Comedoclastin™ that reduces acne lesions in 7 days and prevents recurrence, while mattifying oily, sensitive skin.

Active Ingredients & Other Names
Ingredient Description
Comedoclastin™ (25%) Patented plant active from Milk Thistle seeds that targets micro-comedones, blackheads, and blemishes at the root.

Avene Thermal Spring Water Soothing, anti-irritant support.
Glycerin, PEG-6 Light humectants that hydrate without clogging pores.
Silica, Polyisobutene Provide texture and oil control.

Also known as Cleanance Comedomed Gel Concentrate by Avène.
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Mode of Action
Reduces blemishes by disrupting micro-comedone formation using Comedoclastin™.
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Prevents recurrences: 85–90% of users remained blemish-free at 6 months.
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Mattifies and hydrates oily skin without leaving residue.
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Uses & Indications
Daily treat for active acne (papules, pustules, blackheads, whiteheads)

Ideal for oily, sensitive, or post-treatment support

Safe standalone or in combination with prescription acne therapy (not oral isotretinoin)
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Dosage & Application
Apply twice daily (morning & evening) to cleansed face using 1 pump.

Target T-zone and blemish zones; use gentle circular motions.

No additional moisturiser needed for oily skin; layer with hydration as needed.

Safety & Side Effects
Fragrance- and paraben-free, non-comedogenic, high tolerance.
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Contains isopropyl alcohol (solvent)—can cause mild dryness; pairing with hydration advised.

Rare minor irritation reported; discontinue if persistent.

Warnings & Cautions
External use only

Avoid contact with eyes; rinse immediately if contact occurs

Suitable for teens, adults, and pregnant women

If using exfoliants/retinoids simultaneously, introduce gradually

Drug Classification & Interactions
OTC dermocosmetic acne-targeting moisturiser

No known systemic drug interactions; safe to layer with most topical or oral skin therapies

Clinical Evidence
7-day study (n=51): significant reduction in blemishes.
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90% relapse prevention over 6 months (n=54) with twice-daily use.
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45% fewer imperfections at 8 weeks (vs control).
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High user satisfaction: Reddit reviews describe it as “must-have for keeping whiteheads/blackheads at bay… not drying”!
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FAQ (Q&A Format)
Q: How quickly will I see results?
A: Most users report visible improvement in 7 days, with significant reduction in blemishes and blackheads.

Q: Can it prevent acne from returning?
A: Yes—clinical real-world data show 85–90% relapse prevention at 6 months.

Q: Suitable for pregnant women?
A: Yes, it is safe and fragrance-free.

Q: Can I use it with prescription acne meds?
A: Yes, used safely alongside topical or oral acne treatments, except isotretinoin.

Q: Will it dry out my skin?
A: Its alcohol base can feel drying; pairing with a hydrating layer is recommended for dry skin.

SEO Keywords
Avene Cleanance Comedomed concentrate, acne serum 30 ml, Comedoclastin acne treatment, anti-blemish gel moisturizer, EZ Chemist acne care