Azactam Injection (Aztreonam) – Monobactam Antibiotic for Severe Gram-Negative Infections | EZ Chemist

Azactam Injection (Aztreonam 1g) – Monobactam Antibiotic for Gram-Negative Infections | Buy from EZ Chemist Online Pharmacy

What is Azactam Injection used for?
Azactam Injection contains aztreonam, a monobactam antibiotic used to treat serious gram-negative bacterial infections, including urinary tract infections, pneumonia, sepsis, and intra-abdominal infections. It is administered intravenously or intramuscularly, especially in patients with penicillin allergies.

Brand Name: Azactam

Generic Name: Aztreonam

Form: Powder for solution for injection or infusion

Strengths Available: 500 mg, 1 g, 2 g vials

Route of Administration: Intravenous (IV) or Intramuscular (IM)

Drug Class: Monobactam β-lactam antibiotic

Prescription Status: Prescription-only (Schedule H in India)

Buy Azactam Injection Online at EZ Chemist
Aztreonam – A synthetic monobactam antibiotic that targets gram-negative aerobic bacteria.
Aztreonam injection

Generic Azactam

Monobactam antibiotic

Gram-negative IV antibiotic

Beta-lactam alternative in penicillin allergy
Aztreonam binds to penicillin-binding protein 3 (PBP-3) of susceptible gram-negative bacteria, inhibiting cell wall synthesis. This results in bacterial cell lysis and death. It is highly selective for aerobic gram-negative organisms, with no activity against gram-positive or anaerobic bacteria.
Azactam Injection is indicated for:

Urinary Tract Infections (UTIs)

Lower Respiratory Tract Infections (including hospital-acquired pneumonia)

Intra-abdominal infections (as part of combination therapy)

Septicemia / Bacteremia

Skin and soft tissue infections

Gynecological infections

Surgical prophylaxis (in selected cases)

Suitable for patients with serious beta-lactam (penicillin/cephalosporin) allergies
Indication Typical Adult Dose Frequency Route
UTIs 500 mg–1 g Every 8–12 hours IV or IM
Pneumonia / Intra-abdominal / Sepsis 1–2 g Every 6–8 hours IV
Max daily dose Up to 8 g/day — IV

Pediatric: Dose adjusted based on weight and infection severity

Administer by IV infusion over 20–60 minutes or IM deep injection

Dose adjustments required in renal impairment
Can be used alone or with other antimicrobials depending on infection

In polymicrobial infections, combine with agents active against gram-positive and anaerobes

Suitable as a first-line agent in penicillin-allergic patients for gram-negative infections

Requires baseline renal function testing
Local injection site reaction

Rash

Nausea, vomiting

Diarrhea

Elevated liver enzymes
Clostridioides difficile–associated diarrhea

Anaphylaxis (rare but possible)

Hepatotoxicity

Blood dyscrasias (e.g., neutropenia)
Allergy alert: Although rare, cross-reactivity with other β-lactams may occur

Hepatic monitoring: Recommended in prolonged therapy

Renal impairment: Dose adjustment essential

Superinfection risk: Long-term use may promote resistant organisms

Not effective against anaerobes or gram-positive cocci – should not be used as monotherapy in mixed infections
ATC Code: J01DF01

Pharmacologic Class: Monobactam antibacterial

Legal Status: Schedule H (Rx-only in India)
Interacting Drug/Class Recommendation or Concern
Aminoglycosides May have additive nephrotoxic effects; monitor renal function
Loop diuretics Caution due to risk of renal toxicity
Probenecid May increase aztreonam levels (not commonly used)
Other antibiotics May be used concurrently for synergistic coverage in polymicrobial infections
A 2020 review in Clinical Infectious Diseases confirms that aztreonam is safe and effective in managing multi-drug resistant gram-negative infections, particularly in penicillin-allergic patients.

In clinical trials, Azactam demonstrated cure rates ranging from 75–90% in lower respiratory and urinary tract infections.

Excellent penetration into lung, urine, bile, and peritoneal fluid documented in pharmacokinetic studies.

FAQs – Frequently Asked Questions
Q1: What is Azactam Injection used for?
It is used for treating severe gram-negative infections, such as pneumonia, UTIs, and sepsis, particularly in patients allergic to penicillin.

Q2: Can Azactam be given to patients with penicillin allergy?
Yes, it is one of the few beta-lactams that is safe in most patients with penicillin allergies due to its monobactam structure.

Q3: Is Azactam safe in pregnancy?
Aztreonam is classified as Pregnancy Category B – animal studies show no risk, but human data is limited.

Q4: How is Azactam administered?
It is given by IV infusion over 20–60 minutes or via deep IM injection.

Q5: Does Azactam treat anaerobic infections?
No, Azactam does not cover anaerobes or gram-positive bacteria, so additional agents may be needed.

Q6: Is dosage adjustment required in kidney disease?
Yes, dosage should be reduced in patients with impaired renal function to prevent drug accumulation.

Buy Azactam Injection Online – EZ Chemist
Buy Azactam (Aztreonam) Injection online for targeted treatment of gram-negative infections. Ideal for penicillin-allergic patients. EZ Chemist ensures prescription verification and secure nationwide delivery.

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