Azopt Eye Drops (Brinzolamide 1%) – Intraocular Pressure-Lowering Medication | EZ Chemist
Azopt Eye Drops – Brinzolamide 1% for Intraocular Pressure & Glaucoma Treatment | Buy Online from EZ Chemist Pharmacy
What are Azopt Eye Drops used for?
Azopt Eye Drops contain brinzolamide, a carbonic anhydrase inhibitor used to reduce intraocular pressure (IOP) in conditions like open-angle glaucoma and ocular hypertension. It lowers fluid production in the eye and is administered as an eye drop.
Brand Name: Azopt

Generic Name: Brinzolamide Ophthalmic Suspension 1%

Dosage Form: Sterile ophthalmic suspension

Strength: 1% (10 mg/mL)

Pack Size: 5 mL or 10 mL bottle

Route: Topical ocular (eye drops)

Drug Class: Carbonic Anhydrase Inhibitor (Ophthalmic)

Prescription Status: Prescription-only medication (Rx, Schedule H in India)

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Brinzolamide 1% w/v – A topical carbonic anhydrase II inhibitor that reduces aqueous humor secretion and intraocular pressure.
Brinzolamide Eye Drops

Brinzox

Generic Azopt

Carbonic Anhydrase Inhibitor Drops

Anti-glaucoma medication (topical)
Brinzolamide inhibits the enzyme carbonic anhydrase II, which reduces the formation of bicarbonate ions in the ciliary processes of the eye. This leads to reduced aqueous humor secretion, resulting in lowered intraocular pressure (IOP).

This mechanism is useful in treating:

Open-angle glaucoma

Ocular hypertension
Reduction of elevated intraocular pressure in patients with:

Ocular hypertension

Open-angle glaucoma

Can be used alone or in combination with other IOP-lowering agents (e.g., beta-blockers, prostaglandin analogues)

Patient Type Recommended Dosage
Adults 1 drop in the affected eye(s) twice daily (every 12 hours). Some patients may benefit from 3 times daily dosing

Shake bottle well before use

Avoid contact with dropper tip to prevent contamination

Wait at least 5 minutes before using other ophthalmic drops

If a dose is missed, apply as soon as possible unless it’s near the next dose
Safe for long-term use under medical supervision

Suitable for monotherapy or adjunctive therapy

Monitor IOP periodically to assess response

May take several weeks to achieve full therapeutic effect

Use in pediatric patients not well established
Blurred vision

Eye discomfort

Foreign body sensation

Dry eyes

Bitter taste
Eye allergy or hypersensitivity

Eye inflammation (e.g., conjunctivitis)

Systemic carbonic anhydrase inhibition (rare)

Corneal edema in patients with low endothelial cell count
Avoid use in patients with sulfonamide allergy – Brinzolamide is a sulfonamide derivative

Not recommended in severe renal impairment (CrCl < 30 mL/min)

Use with caution in hepatic impairment

Monitor patients with corneal abnormalities closely

Do not use while wearing contact lenses – remove lenses before application and reinsert after 15 minutes

Pregnancy Category C – use only if clearly needed
ATC Code: S01EC04

Drug Class: Ophthalmic Carbonic Anhydrase Inhibitor

Schedule H (India) – Prescription-only
Drug/Class Interaction/Precaution
Oral carbonic anhydrase inhibitors Risk of additive systemic effects (e.g., acidosis)
Salicylates (aspirin) Potential increased risk of metabolic acidosis
Other IOP-lowering agents Monitor for additive hypotensive effects
Systemic sulfonamides Risk of cross-sensitivity
Multicenter trials comparing Azopt vs dorzolamide showed comparable IOP reduction with better ocular comfort.

Phase III studies: Brinzolamide achieved IOP reduction of 4–6 mmHg from baseline, effective both as monotherapy and adjunctive therapy.

Comparative analysis (Ophthalmology Journal, 2017) found brinzolamide associated with lower ocular surface irritation than dorzolamide.

FAQs – Frequently Asked Questions
Q1: What are Azopt Eye Drops used for?
They are used to reduce elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.

Q2: Can Azopt be used with other eye drops?
Yes. Use other eye medications at least 5 minutes apart to prevent washout.

Q3: Is Azopt safe for people allergic to sulfa drugs?
No. As a sulfonamide derivative, Azopt may cause hypersensitivity reactions in these individuals.

Q4: Can I use Azopt while wearing contact lenses?
Remove lenses before use and wait at least 15 minutes before reinserting them.

Q5: How quickly does Azopt work?
It starts lowering IOP within a few hours, with peak effects seen in several weeks of regular use.

Q6: Can Azopt be used during pregnancy?
It is a Category C drug; use only if clearly needed and under physician supervision.

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