Azor (Azilsartan Medoxomil / Amlodipine Besylate)
Compared with: Blackmores Conceive Well Gold 28 Tablets + 28 Capsules
Azor (Azilsartan / Amlodipine) once‑daily combination tablet effectively lowers blood pressure by combining an angiotensin II receptor blocker (ARB) with a calcium channel blocker (CCB). This dual mechanism provides superior systolic and diastolic reduction versus monotherapy, improving cardiovascular outcomes in patients with essential hypertension.

Azilsartan Medoxomil – 40 mg (prodrug converted to azilsartan)
Amlodipine Besylate – 5 mg
Also available as Azor® 40 / 10 mg (azilsartan 40 mg / amlodipine 10 mg).
Dual‑action ARB + CCB

Azilsartan/Amlodipine Fixed‑Dose Combination

Edarbi / Norvasc Combination (component brands)

Azilsartan Besylate with Amlodipine

Azilsartan selectively antagonises angiotensin II type 1 (AT₁) receptors, preventing vasoconstriction, aldosterone release, and sodium retention.

Amlodipine inhibits L‑type calcium channels in vascular smooth muscle, causing prolonged vasodilation and reduced peripheral resistance.

The complementary actions produce additive blood pressure lowering and reduce compensatory reflex tachycardia.

Essential Hypertension: For patients inadequately controlled on monotherapy with either an ARB or a CCB.

Combination Therapy: Preferred when single‑agent therapy fails to achieve target blood pressure.
Patient Group Dose Frequency Notes
Adults 1 tablet (azilsartan 40 mg / amlodipine 5 mg) Once daily May increase to 40 / 10 mg after 2–4 weeks if needed
Renal Impairment No adjustment required if eGFR ≥15 mL/min Avoid ARBs if eGFR <15 mL/min
Elderly (≥65 years) Start with 40 / 5 mg; careful titration Once daily Monitor blood pressure and renal function

Administration: Swallow whole with water; may be taken with or without food at the same time each day.

Missed Dose: Take as soon as remembered unless within 12 hours of next dose; do not double.
Formulation: Film‑coated oral tablet

Strengths: 40 / 5 mg, 40 / 10 mg

Route: Oral

Legal Status: Prescription Only Medicine
Pregnancy: Category D – Contraindicated in second and third trimesters (risk of fetal toxicity).

Breastfeeding: Use alternative therapy; components excreted in breast milk.

Hepatic Impairment: Use with caution in severe hepatic dysfunction; amlodipine is metabolised hepatically.

Renal Impairment: Azilsartan requires no adjustment if eGFR ≥15 mL/min.
Peripheral edema

Dizziness, headache

Fatigue

Flushing

Serious (rare):

Hypotension, syncope

Hyperkalemia

Hepatic enzyme elevations

Angioedema
Hypotension: Use caution in volume‑depleted patients; correct dehydration before initiation.

Electrolytes: Monitor serum potassium—risk of hyperkalemia with ARB component.

Drug Withdrawal: Do not discontinue abruptly; may cause rebound hypertension.

Heart Failure: Monitor closely if used in heart failure patients—rare risk of worsening.
Therapeutic Class: Antihypertensive Combination

Pharmacologic Class: ARB (Azilsartan) + CCB (Amlodipine)

Legal Category: Prescription Only
CYP3A4 Inhibitors (e.g., ketoconazole): Increase amlodipine levels; monitor for hypotension.

NSAIDs: May attenuate antihypertensive effect and exacerbate renal impairment.

Potassium‑Sparing Diuretics / Supplements: Additive hyperkalemia risk; monitor potassium.

Other Antihypertensives: Additive hypotensive effects—monitor blood pressure.

Lithium: ARBs may increase lithium levels; monitor serum lithium.
A randomized trial demonstrated Azor 40 / 5 mg reduced systolic BP by 20 mm Hg versus 12 mm Hg with azilsartan monotherapy (Weir et al., J Hypertens 2014).

Meta‑analysis confirms superior 24‑hour BP control and pulse pressure reduction with ARB + CCB combinations.

FAQs – Azor (Azilsartan / Amlodipine)
Q1. When will I see blood pressure reduction?
A: Onset within 1 hour; peak effect at 4–6 hours; full effect after 2–4 weeks.

Q2. Can I take Azor with food?
A: Yes; food does not affect absorption.

Q3. What monitoring is needed?
A: Check BP, renal function, and electrolytes at baseline, after dose changes, and periodically.

Q4. Is Azor suitable for elderly patients?
A: Yes—initiate at 40 / 5 mg and monitor for hypotension and renal changes.

Q5. Can Azor improve heart health beyond BP control?
A: ARB + CCB combinations reduce arterial stiffness and may lower cardiovascular event risk versus monotherapy.

Q6. What should I do if I miss a dose?
A: Take within 12 hours; otherwise, skip and resume next day—do not take double.

Q7. Can Azor replace separate pills?
A: Yes; combination improves adherence and simplifies therapy for patients uncontrolled on monotherapy.

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