Generic Benace (Benazepril HCl) Tablets – ACE Inhibitor for Hypertension & Heart Failure
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What is Generic Benace used for?
Generic Benace, containing Benazepril hydrochloride, is used to lower high blood pressure and treat heart failure. It belongs to the ACE inhibitor class, helping to relax blood vessels and reduce the heart's workload, thereby preventing strokes, heart attacks, and kidney problems.
Generic Name: Benazepril Hydrochloride

Brand Name Equivalent: Benace

Available Strengths: 5 mg, 10 mg, 20 mg, 40 mg

Drug Class: ACE inhibitor (Angiotensin-Converting Enzyme Inhibitor)

Route of Administration: Oral

Prescription Required: Yes

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Benazepril Hydrochloride

Prodrug converted in the liver to benazeprilat, the active metabolite
Benace

Benazepril HCl

Generic Benazepril

ACE inhibitor antihypertensive

Benazepril tablets
Benazepril is a long-acting ACE inhibitor that:

Blocks the angiotensin-converting enzyme, reducing formation of angiotensin II

Leads to vasodilation, decreased aldosterone secretion, and reduced blood pressure

Improves cardiac output in heart failure

Offers renal protection in hypertensive and diabetic nephropathy patients
Hypertension (High Blood Pressure) – First-line therapy
Congestive Heart Failure – Adjunctive treatment
Chronic Kidney Disease (CKD) – To reduce progression
Left Ventricular Dysfunction – Post-myocardial infarction
Condition Starting Dose Maintenance Dose
Hypertension (Adults) 10 mg once daily 20–40 mg daily (once or divided)
Heart Failure 5 mg once daily Adjust gradually up to 40 mg
Pediatrics (≥6 yrs) 0.2 mg/kg once daily (max 10 mg) Adjust as per response
May be taken with or without food
Dosage should be reduced in renal impairment
Absorption: ~37% bioavailability

Onset of Action: Within 1 hour

Peak Effect: 6 hours

Metabolism: Hepatic conversion to benazeprilat

Excretion: Renal (benazeprilat), fecal
Dry cough

Headache

Dizziness

Fatigue

Nausea
Angioedema (swelling of face/throat)

Hyperkalemia (elevated potassium)

Hypotension (especially in salt-depleted patients)

Kidney function decline
Black Box Warning (Pregnancy): Discontinue immediately if pregnancy is detected – fetal toxicity risk

Monitor renal function and potassium levels regularly

Caution in patients with bilateral renal artery stenosis

Not recommended in patients with history of ACE inhibitor–induced angioedema
Pharmacologic Class: ACE Inhibitor

ATC Code: C09AA07

Legal Classification: Schedule H (Prescription drug – India)
Interacting Drug/Class Effect and Recommendation
Potassium supplements/diuretics Increases risk of hyperkalemia – monitor closely
NSAIDs (ibuprofen, naproxen) May reduce antihypertensive efficacy – monitor BP and renal function
Lithium Risk of lithium toxicity – avoid if possible
Diuretics Enhanced risk of hypotension on initial dosing

Clinical Studies and Efficacy
BENESTENT Trial (Hypertension): Benazepril significantly reduced systolic and diastolic BP over 24 hours.

REIN Study (CKD): ACE inhibitors, including benazepril, delayed progression to ESRD in patients with proteinuric nephropathy.

SOLVD Trial (CHF): Improvement in symptoms and reduced hospitalization when combined with standard CHF therapy.

Frequently Asked Questions (FAQs)
Q1: What is Generic Benace used to treat?
Generic Benace (Benazepril) is primarily used to treat high blood pressure and heart failure, and to protect kidney function in certain patients.

Q2: Is Benazepril safe in pregnancy?
No. Benazepril is contraindicated in pregnancy due to risk of serious fetal harm and should be discontinued immediately if pregnancy occurs.

Q3: Can I take Benace with food?
Yes. It can be taken with or without meals, although taking it at the same time each day is recommended.

Q4: What should I do if I miss a dose?
Take the missed dose as soon as remembered. If it's close to the next dose, skip the missed dose. Do not double the dose.

Q5: Can I take Benazepril with diuretics?
Yes, but it should be initiated carefully as the combination can lead to excessive hypotension. Electrolyte monitoring is essential.

Q6: Is cough a common side effect of Benace?
Yes, a persistent dry cough is a well-known class effect of ACE inhibitors and may require switching to an ARB.
Store in a cool, dry place below 25°C

Protect from light and moisture

Keep out of reach of children
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