Benicar HCT – Dual-Action Antihypertensive (Olmesartan Medoxomil + Hydrochlorothiazide) | EZ Chemist
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What is Benicar HCT used for
Benicar HCT is a combination medication used to treat high blood pressure (hypertension). It contains Olmesartan medoxomil, an angiotensin II receptor blocker (ARB), and Hydrochlorothiazide, a thiazide diuretic. Together, they help relax blood vessels and reduce fluid retention, lowering the risk of stroke and heart attack.
Generic Name: Olmesartan Medoxomil + Hydrochlorothiazide

Brand Name: Benicar HCT
Olmesartan 20 mg + HCTZ 12.5 mg
Olmesartan 40 mg + HCTZ 12.5 mg
Olmesartan 40 mg + HCTZ 25 mg
Drug Class: ARB + Thiazide Diuretic Combination
Route: Oral
Prescription Required: Yes
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Olmesartan Medoxomil – Angiotensin II Receptor Blocker

Hydrochlorothiazide – Thiazide Diuretic

Other Common Names
Olmesartan HCTZ

Olmesartan + HCT

ARB with Diuretic for Hypertension

Dual-action antihypertensive

Benicar with Hydrochlorothiazide

Blocks angiotensin II from binding to AT1 receptors

Prevents vasoconstriction and aldosterone secretion

Result: Vasodilation and decreased blood pressure

Hydrochlorothiazide (HCTZ):

Inhibits sodium-chloride symporter in the distal tubule

Promotes excretion of sodium, chloride, and water

Result: Reduced blood volume and blood pressure
Essential Hypertension (High Blood Pressure): In patients not adequately controlled with monotherapy
Cardiovascular Risk Reduction: By controlling chronic hypertension
Fluid Retention Reduction: In hypertensive patients with mild edema
Strength Initial Dose Maintenance Dose
20/12.5 mg or 40/12.5 mg Once daily orally Up to 40/25 mg daily

Maximum Dose: 40 mg Olmesartan + 25 mg HCTZ once daily

Take with or without food

Not recommended for children under 18 years

Renal and hepatic impairment: Use caution, start with the lower dose and monitor renal function closely.
Onset of Action: Within 1–2 hours

Peak Effect: 4–6 hours

Half-life:

Olmesartan: ~13 hours

Hydrochlorothiazide: ~10 hours

Metabolism: Olmesartan is converted to its active form in the liver

Excretion: Renal and biliary (Olmesartan); renal (HCTZ)
Dizziness or lightheadedness

Headache

Fatigue

Nausea

Increased urination
Electrolyte Imbalance (e.g., hypokalemia, hyponatremia)

Severe hypotension, especially in volume-depleted patients

Angioedema (rare)

Renal function impairment

Hyperuricemia or gout exacerbation
Black Box Warning – Pregnancy: May cause fetal harm if used during pregnancy. Discontinue as soon as pregnancy is detected.

Use cautiously in patients with:

Renal artery stenosis

Volume depletion or dehydration

Severe hepatic impairment

Monitor: Blood pressure, electrolytes (especially potassium and sodium), renal function
Pharmacologic Class: Angiotensin II Receptor Blocker + Thiazide Diuretic

ATC Code: C09DA08

Legal Classification: Schedule H (Rx only in India)
Interacting Substance Outcome and Recommendation
NSAIDs (ibuprofen, naproxen) May reduce antihypertensive effect; renal risk
Potassium supplements Risk of hyperkalemia – avoid or monitor closely
Lithium Risk of lithium toxicity – avoid concurrent use
Alcohol or sedatives May enhance hypotensive effects
Antidiabetics (insulin/oral) May require dose adjustment – HCTZ may affect glucose tolerance

Clinical Studies & Efficacy
COACH Study (2007): Combination of olmesartan + HCTZ demonstrated significantly greater BP reduction vs monotherapy.

Clinical Pharmacology Review – FDA: Demonstrated consistent 24-hour BP control and tolerability in over 2,600 patients.

Meta-analysis (JNC 8 guidelines): ARB + diuretic combinations reduce systolic and diastolic BP effectively with fewer side effects compared to beta-blocker-based regimens.

FAQs – Benicar HCT
Q1: What is Benicar HCT used for?
Benicar HCT is used to treat high blood pressure, especially in patients not controlled with a single medicine.

Q2: Can I take Benicar HCT if I am pregnant?
No. This medication is contraindicated during pregnancy due to risk of severe fetal injury or death.

Q3: How long does Benicar HCT take to work?
Initial effects may be seen within 1–2 hours, with full effects in 2 weeks.

Q4: What should I do if I miss a dose?
Take the missed dose as soon as you remember, unless it's near the next dose. Do not double the dose.

Q5: Can I take potassium supplements with Benicar HCT?
Avoid potassium supplements unless advised by a doctor, due to risk of high potassium levels.

Q6: Does Benicar HCT cause frequent urination?
Yes. Due to the diuretic effect of hydrochlorothiazide, increased urination is common, especially early in treatment.
Store below 25°C in a dry place

Protect from moisture and light

Keep away from children

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