Product Description Guide: Boniva (Ibandronate Sodium) Tablets
Boniva (Ibandronate Sodium) is a prescription medication used to treat and prevent osteoporosis in postmenopausal women. It works by slowing bone loss and increasing bone mass to help reduce the risk of fractures.
Boniva
Ibandronate Sodium
150 mg Oral Tablet (Monthly)

3 mg/3 mL IV Injection (Every 3 Months, healthcare setting)
Ibandronate Sodium
Ibandronate

Ibandronic Acid

Bonviva (Brand name in some countries)
Therapeutic Class: Bisphosphonate

Pharmacological Class: Bone Resorption Inhibitor

ATC Code: M05BA06

Schedule: S4 (Prescription-Only Medicine in Australia)
Boniva works by inhibiting osteoclast-mediated bone resorption, which slows down bone loss. It binds strongly to hydroxyapatite crystals in bone and specifically reduces the activity of cells that break down bone (osteoclasts), allowing bone-forming cells (osteoblasts) to restore bone mass and improve bone density over time.
Treatment of osteoporosis in postmenopausal women

Prevention of postmenopausal osteoporosis

Helps reduce the risk of vertebral fractures
Clinical trials show Boniva increases bone mineral density (BMD) and reduces the incidence of new vertebral fractures in postmenopausal women (PTH Study Group, 2002, NEJM).

Monthly dosing shown to be as effective as daily/weekly bisphosphonates with better adherence (Delmas et al., Osteoporosis Int., 2006).
Oral Tablet (150 mg):

Take one 150 mg tablet once monthly, on the same date each month

Take first thing in the morning with plain water (180–240 mL)

Do not eat, drink (other than water), lie down, or take other medications for at least 60 minutes after taking

IV Injection (3 mg/3 mL):

Administered once every 3 months via intravenous injection by a healthcare professional
Must be taken on an empty stomach

Ensure adequate calcium and vitamin D intake

Prescribing & Administration Considerations:
Contraindicated in patients with hypocalcemia

Not recommended in severe renal impairment (CrCl <30 mL/min)

Consider dental evaluation prior to treatment initiation in patients with risk factors for osteonecrosis of the jaw

Switch to IV formulation if patient experiences GI intolerance
Back pain

Headache

Dyspepsia

Musculoskeletal pain

Flu-like symptoms (IV only)
Esophageal ulceration or irritation (oral)

Osteonecrosis of the jaw (ONJ)

Atypical femoral fractures (rare, long-term use)

Severe bone, joint, or muscle pain

Hypocalcemia (especially in IV users)
Do not administer to patients who cannot stand or sit upright for 60 minutes

Discontinue use in patients with severe GI disorders like esophagitis

Monitor renal function during IV therapy

Use with caution in patients with asthma or aspirin sensitivity

Consider drug holiday after 3–5 years of use in low fracture risk patients
Calcium, magnesium, iron supplements, and antacids: Interfere with absorption. Take at least 60 minutes after Boniva.

NSAIDs: Increase risk of GI irritation

Diuretics and corticosteroids: May enhance risk of hypocalcemia

Aminoglycosides: Enhance risk of renal dysfunction and hypocalcemia
Store at room temperature (15–30°C)

Protect from moisture and heat

Keep in original packaging until use

Frequently Asked Questions (FAQ)
Q: What is Boniva used for?
A: Boniva is prescribed for the treatment and prevention of postmenopausal osteoporosis. It helps reduce bone loss and lowers the risk of vertebral fractures.

Q: How often should I take Boniva?
A: The tablet form is taken once a month. The injectable form is administered once every three months by a healthcare provider.

Q: Can I lie down after taking Boniva?
A: No. You must remain upright (sitting or standing) for at least 60 minutes after taking the oral tablet to reduce the risk of esophageal irritation.

Q: Is Boniva safe in pregnancy?
A: Boniva is not recommended during pregnancy or lactation. It is intended for postmenopausal women.

Q: Can Boniva be taken with calcium supplements?
A: Calcium supplements should not be taken within 60 minutes of Boniva to avoid interference with absorption.

Q: Is Boniva better than other bisphosphonates like Fosamax or Actonel?
A: Boniva is comparable in efficacy but offers monthly dosing, which may improve adherence over weekly bisphosphonates.
Buy Boniva online Australia

Boniva ibandronate sodium 150 mg tablets

Monthly osteoporosis treatment for women

Boniva vs Fosamax comparison

Ibandronate sodium for bone health

Boniva side effects and dosage guide

Bisphosphonate therapy for postmenopausal osteoporosis

Prescription Boniva tablets near me

Boniva 150 mg price and uses

Boniva injection 3 mg every 3 months

Postmenopausal osteoporosis medication

Bone resorption inhibitor

Ibandronate treatment

Fracture prevention medicine

Oral bisphosphonate

Long-acting osteoporosis therapy

Vertebral fracture risk reduction

Bone health for women