Brevibloc Injection (Esmolol HCl) – Short-Acting Beta Blocker for Acute Arrhythmia

Buy Brevibloc Injection (Esmolol) – Rapid-Acting Beta Blocker for Arrhythmias and Hypertension
What is Brevibloc injection used for
Brevibloc (Esmolol Hydrochloride) is a short-acting beta-1 selective adrenergic blocker used intravenously to treat supraventricular tachycardia, hypertension during surgery, and acute arrhythmias. It offers rapid onset and controlled duration of action, ideal for short-term cardiovascular management.

Generic Name: Esmolol Hydrochloride

Brand Name: Brevibloc

Form: Injection (Intravenous)

Strengths Available: 100 mg/10 mL, 250 mg/25 mL, 100 mg/mL (Premixed Bags)

Route of Administration: IV only

Use: Hospital/clinical prescription

ATC Code: C07AB09

Manufacturer: Baxter, Astellas Pharma
Buy Brevibloc Injection Online – EZ Chemist

Esmolol Hydrochloride
A cardioselective beta-1 adrenergic blocker with an ultrashort half-life (~9 minutes) and rapid onset.
Esmolol Injection

Esmolol HCl IV

Brevibloc IV

Ultra-short acting beta blocker

Short-term cardiac arrhythmia control injection
Esmolol acts by selectively blocking beta-1 adrenergic receptors in the heart, reducing heart rate, myocardial oxygen demand, and contractility. Its short half-life allows precise titration and quick reversal if needed.

Onset of Action: Within 1–2 minutes

Peak Effect: ~6–10 minutes

Duration: 10–20 minutes
Rapid control of ventricular rate in supraventricular tachyarrhythmias

Control of perioperative hypertension and tachycardia

Management of intraoperative or postoperative arrhythmias

Emergency cardiac rate control in critically ill patients
Administered by healthcare professionals only.

Standard Dosage for SVT (Supraventricular Tachycardia):

Loading dose: 500 mcg/kg IV over 1 minute

Maintenance infusion: 50 mcg/kg/min for 4 minutes

If response is inadequate, loading dose may be repeated (up to 300 mcg/kg/min max)
Use a dedicated IV line

Monitor BP, ECG, and heart rate continuously

Reduce infusion rate when target heart rate is achieved

Prescribing and Safety Information
Reserved for hospital or ICU use

Requires ECG and hemodynamic monitoring

Not for bolus in bradycardia or AV block patients

Taper down gradually when discontinuing
Hypotension

Bradycardia

Dizziness

Nausea

Injection site reactions

Severe (rare):

Heart block

Cardiac arrest

Bronchospasm (especially in asthma patients)

CNS depression
Contraindicated in sinus bradycardia, overt cardiac failure, or AV block (2nd/3rd degree)

Use caution in patients with renal impairment

Avoid abrupt withdrawal

Asthma and COPD patients require close monitoring

Hypoglycemia symptoms may be masked
Pharmacological Class: Beta-Adrenergic Blocker, Cardioselective

Schedule: Prescription only (Rx)

Pregnancy Category: C (Use only if clearly needed)
Interacting Drug Effect
Calcium channel blockers Enhanced bradycardia, AV block
Digoxin Increased risk of AV block
Insulin/Oral hypoglycemics May mask hypoglycemic symptoms
Anesthetics Potentiates myocardial depression
Other beta-blockers Additive bradycardia or heart block

Clinical Studies and Efficacy
Study 1 – J Am Coll Cardiol (1990):
Esmolol effectively reduced heart rate in SVT within 2–4 minutes and was rapidly reversible.

Study 2 – Crit Care Med (2001):
Used safely in ICU patients with tachyarrhythmias; controlled dosing minimized hypotension.

Study 3 – Anesth Analg (2008):
Showed utility in managing intraoperative tachycardia during general surgery with superior control over other agents like labetalol.

FAQs – Brevibloc Injection
Q1: What is Brevibloc used for?
Brevibloc is used to manage acute arrhythmias and control heart rate in emergency and surgical settings.

Q2: How fast does Brevibloc work?
It begins acting within 1–2 minutes and peaks in effect by 6–10 minutes.

Q3: Can Brevibloc be used for long-term therapy?
No, it is strictly for short-term IV use in acute clinical settings.

Q4: Who should not receive Brevibloc?
Patients with severe bradycardia, AV block, or acute heart failure should not receive it.

Q5: Is Brevibloc safe during pregnancy?
It should be used only if clearly necessary, as human data are limited (Pregnancy Category C).
Store between 20°C to 25°C

Protect from light

Do not use if the solution is discoloured or contains particulates

Single-use vials – discard unused portion
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