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Comprehensive Product Description Guide: Generic Brilinta (Ticagrelor)
What is Generic Brilinta used for?
Generic Brilinta (Ticagrelor) is an antiplatelet medication used to reduce the risk of heart attack, stroke, and cardiovascular death in patients with acute coronary syndrome (ACS) or a history of myocardial infarction. It works by preventing blood clots through inhibition of platelet aggregation.
Generic Brilinta
Ticagrelor
90 mg Tablets (twice daily dosing for ACS)
60 mg Tablets (once-daily maintenance after 12 months of ACS event)
Other Popular or Common Names:
Ticagrelor
Antiplatelet Ticagrelor
Brilinta Generic
Platelet Aggregation Inhibitor
P2Y12 Inhibitor
Therapeutic Class: Antiplatelet Agent
Pharmacological Class: P2Y12 Platelet Inhibitor
ATC Code: B01AC24
Prescription Only (Schedule S4 in Australia)
Ticagrelor
Ticagrelor selectively and reversibly inhibits the P2Y12 adenosine diphosphate (ADP) receptor on platelet surfaces, preventing activation and aggregation of platelets. Unlike clopidogrel, ticagrelor does not require metabolic activation, offering rapid onset and more consistent platelet inhibition.
Acute Coronary Syndrome (ACS)
History of Myocardial Infarction (to reduce recurrent CV events)
Prevention of thrombotic events after percutaneous coronary intervention (PCI)
Used in combination with low-dose aspirin (75–100 mg)
The PLATO trial (NEJM, 2009) demonstrated ticagrelor reduced the rate of death from vascular causes, myocardial infarction, or stroke compared to clopidogrel.
A sub-study confirmed ticagrelor's superiority even in high-risk patients with prior MI or stenting (Bonaca et al., Circulation, 2015).
Initial Dose for ACS:
180 mg orally (2 x 90 mg tablets) as a loading dose
Maintenance Dose (First 12 months):
90 mg orally twice daily
Always combined with low-dose aspirin (75–100 mg)
After 12 Months:
60 mg twice daily if long-term therapy is indicated
Administer with or without food
Do not exceed aspirin doses above 100 mg daily
Swallow whole; do not crush or split
Evaluate bleeding risk before initiating
Monitor renal and hepatic function in patients with impairment
Regularly assess adherence and dyspnea symptoms
Discontinue 5 days before surgery (if not urgent)
Dyspnea (shortness of breath)
Dizziness
Nausea
Headache
Bradycardia
Major bleeding (especially gastrointestinal, intracranial)
Ventricular pauses
Hyperuricemia
Severe hepatic impairment (contraindicated)
Bleeding risk: Avoid in patients with active bleeding or history of intracranial hemorrhage
Asthma or COPD: Dyspnea may worsen symptoms
Bradyarrhythmias: Monitor heart rhythm, especially in patients on beta-blockers
Not recommended for use in severe hepatic dysfunction
Use caution in renal impairment and elderly patients
Aspirin >100 mg/day: Reduces efficacy, increases bleeding
Strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir): Increase ticagrelor levels
CYP3A4 inducers (e.g., rifampicin, phenytoin): Reduce efficacy
Statins (simvastatin, lovastatin >40 mg): Increased risk of side effects
Digoxin: Ticagrelor increases digoxin levels – monitor closely
Store below 25°C
Keep in original blister packaging
Protect from moisture and heat
Keep out of reach of children
Frequently Asked Questions (FAQs)
Q: What is Generic Brilinta used for?
A: Generic Brilinta (Ticagrelor) is used to prevent blood clots in people with acute coronary syndrome or a previous heart attack. It reduces the risk of death from cardiovascular causes, heart attack, or stroke.
Q: How is Generic Brilinta different from Clopidogrel?
A: Ticagrelor offers faster and more consistent platelet inhibition than clopidogrel, does not require activation by liver enzymes, and has shown better outcomes in large-scale studies like PLATO.
Q: Can I take Generic Brilinta with aspirin?
A: Yes, it should be taken with low-dose aspirin (75–100 mg/day). Higher doses reduce its effectiveness and increase bleeding risk.
Q: What should I do if I miss a dose?
A: Skip the missed dose and take your next dose at the regular time. Do not double up.
Q: Is it safe during pregnancy or breastfeeding?
A: Ticagrelor is not recommended during pregnancy or breastfeeding due to potential bleeding risk to the fetus or infant.
Q: What should I watch for while taking Ticagrelor?
A: Signs of bleeding (bruising, nosebleeds, blood in stool/urine), shortness of breath, or irregular heartbeat should be reported immediately.
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