Comprehensive Product Description Guide: Caduet
What is Caduet used for
Caduet is a prescription medicine that combines two active ingredients—amlodipine and atorvastatin. It is used to treat high blood pressure (hypertension) and high cholesterol in a single tablet, reducing the risk of heart attack, stroke, and other cardiovascular events in patients with multiple risk factors.
Caduet
Amlodipine + Atorvastatin

5/10 mg, 5/20 mg, 10/10 mg, 10/20 mg, 10/40 mg, 10/80 mg
Amlodipine and Atorvastatin combination

Dual therapy for heart and cholesterol

Caduet tablets

Norvasc + Lipitor combo

Amlodipine besilate + Atorvastatin calcium

Therapeutic Class: Antihypertensive + Lipid-lowering agent

Amlodipine: Calcium Channel Blocker (Dihydropyridine class)

Atorvastatin: HMG-CoA Reductase Inhibitor (Statin)

ATC Code: C10BX03

Schedule: Prescription Only (S4 Australia)
Amlodipine besilate

Atorvastatin calcium
Amlodipine:
A long-acting calcium channel blocker that inhibits calcium influx into vascular smooth muscle and myocardium, leading to vasodilation and lowered blood pressure.

A statin that inhibits HMG-CoA reductase, the enzyme responsible for cholesterol synthesis in the liver. It lowers LDL cholesterol, raises HDL, and reduces triglycerides, thus preventing atherosclerotic plaque formation.
Management of hypertension and hypercholesterolemia in one tablet

Prevention of cardiovascular events in patients with combined risk factors

Patients requiring both blood pressure and cholesterol control

Post-myocardial infarction secondary prevention
TNT Study: Atorvastatin 80 mg significantly reduced major cardiovascular events in high-risk patients (NEJM, 2005)

ALLHAT Study: Amlodipine shown to be effective in lowering BP and reducing heart failure incidence

Combination therapy improves adherence and treatment efficacy (JAMA Internal Medicine, 2016)
Starting Dose:

Individualised based on current monotherapy use

Common starting dose: 5/10 mg or 10/10 mg once daily
Adjust according to therapeutic goals (BP control and lipid targets)

Maximum dose: 10 mg Amlodipine + 80 mg Atorvastatin per day
Once daily, with or without food

Swallow whole with water

Can be taken at any time of day (preferably same time daily)

Prescribing and Monitoring:
Lipid profile and liver function at baseline and regularly thereafter

Blood pressure monitoring

Consider CK levels if patient experiences unexplained muscle pain

Dose adjustment in elderly, hepatic impairment, and renal dysfunction
Common:
Swelling of ankles or feet (due to amlodipine)

Headache

Dizziness or fatigue

Muscle pain

Abdominal pain, nausea

Serious:
Rhabdomyolysis (rare but serious with statins)

Liver enzyme elevation

Hypotension or chest pain on initiation

Allergic reactions
Contraindicated in active liver disease

Avoid grapefruit juice (increases atorvastatin levels)

Use with caution in heart failure with reduced ejection fraction

Pregnancy Category X: Contraindicated in pregnancy and lactation

Discontinue if significant muscle toxicity or liver damage occurs
CYP3A4 inhibitors (e.g., clarithromycin, ketoconazole) increase atorvastatin toxicity

Cyclosporine, gemfibrozil, niacin: Increased risk of myopathy

Grapefruit juice: Increases atorvastatin serum levels

Simultaneous use with other antihypertensives: Additive BP-lowering effect

Digoxin: May increase digoxin levels slightly with amlodipine
Store below 25°C

Protect from moisture and direct sunlight

Keep out of reach of children

Do not use after expiry date

Frequently Asked Questions (FAQs)
Q: What is Caduet used for?
A: Caduet is prescribed to patients who need treatment for both high blood pressure and high cholesterol. It helps reduce the risk of heart attack, stroke, and other cardiovascular complications.

Q: Is Caduet better than taking two separate pills?
A: Caduet improves treatment adherence by combining two essential medications into one tablet, helping patients consistently manage both conditions.

Q: Can I stop taking Caduet once my BP and cholesterol are normal?
A: No. Caduet is a long-term medication. Discontinuing it without medical advice may increase the risk of cardiovascular events.

Q: Are there any food restrictions while using Caduet?
A: Avoid grapefruit and grapefruit juice as they can interact with atorvastatin and increase side-effect risk.

Q: Can I take Caduet during pregnancy?
A: No. Atorvastatin can harm fetal development. Caduet must be discontinued before conception or during pregnancy.

Q: How long does it take for Caduet to work?
A: Blood pressure lowering occurs within a few days; cholesterol levels may take 2–4 weeks to show improvement.
Buy Caduet tablets online Australia

Amlodipine and atorvastatin combination pill

Blood pressure and cholesterol medication combo

Best medication for high BP and LDL

Caduet dosage 5/10, 10/20 mg online

Where to buy Caduet prescription tablets

Statin and calcium channel blocker in one pill

Treat hypertension and dyslipidemia together

Caduet for cardiovascular prevention

Caduet prescription price and availability