Cafcit Syrup (Caffeine Citrate) Oral Solution – Neonatal Apnea Treatment

Buy Cafcit Syrup Online – Caffeine Citrate Oral Solution for Neonatal Apnea
What is Cafcit Syrup used for?
Cafcit Syrup is an oral caffeine citrate solution prescribed to treat apnea of prematurity in neonates. It works by stimulating the respiratory center in the brain to reduce the frequency of apnea episodes in premature infants.
Generic Name: Caffeine Citrate

Brand Name: Cafcit

Other Names: Caffeine Citrate Oral Solution

Strength: 60 mg/3 mL (equivalent to 20 mg/mL of caffeine citrate)

Form: Oral solution / Syrup

Drug Class: Central Nervous System Stimulant (Methylxanthine)

Prescription Status: Rx Only (Prescription Required)

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Caffeine Citrate
Each 3 mL of solution contains 60 mg caffeine citrate (equivalent to 30 mg caffeine base).
Caffeine Oral Solution

Neonatal caffeine

Caffeine for apnea

Methylxanthine solution
Caffeine citrate is a central nervous system stimulant in the methylxanthine class. It works by:

Stimulating the medullary respiratory center in the brain

Enhancing minute ventilation

Increasing sensitivity to CO₂

Improving skeletal muscle tone, including the diaphragm

This leads to a reduction in apnea episodes in premature infants.
Treatment of apnea of prematurity in infants between 28–33 weeks gestational age

Off-label Uses (with physician guidance):

Respiratory stimulation during extubation

Postoperative apnea prophylaxis

As an adjuvant in neonatal sepsis-associated bradycardia

Neonatal Dosage (Under Specialist Supervision):

Loading dose: 20 mg/kg caffeine citrate orally (equivalent to 10 mg/kg caffeine base)

Maintenance dose: 5 mg/kg caffeine citrate once daily (equivalent to 2.5 mg/kg caffeine base)

Dose should be adjusted based on clinical response and serum levels
Use calibrated oral syringe. Can be given directly or mixed with a small amount of breast milk/formula.
Start treatment under neonatal specialist supervision

Monitor serum caffeine levels if therapy >7 days or with hepatic/renal impairment

Assess for signs of toxicity, dehydration, and feeding intolerance
Use only in neonatal ICU settings or under hospital supervision

Monitor weight, heart rate, respiratory rate, and serum caffeine

Therapeutic range: 5–25 mcg/mL of caffeine base
Common Adverse Effects Serious (Less Common)
Feeding intolerance Seizures (with toxic levels)
Irritability or jitteriness Cardiac arrhythmias
Tachycardia NEC (rare; necrotizing enterocolitis)
Increased gastric acid secretion Hyperglycemia
Caution in renal or hepatic impairment

Avoid with concurrent methylxanthines (e.g., theophylline)

Do not use in term infants or outside neonatal ICU

Adjust dosing in cases of dehydration, sepsis, or prolonged exposure
Pharmacologic Class: Methylxanthine CNS Stimulant

Therapeutic Class: Respiratory Stimulant

Pregnancy Category: Not applicable (used in neonates)

Schedule: Prescription-only medicine (Rx)
Drug/Class Interaction Effect
Theophylline Additive effect; avoid co-administration
Cimetidine Increases caffeine levels via CYP inhibition
Ketoconazole May increase caffeine levels
Phenobarbital May reduce caffeine effectiveness
Oral contraceptives Not relevant in neonates, but slows metabolism
Schmidt B et al., NEJM (2006) – Caffeine for Apnea of Prematurity (CAP Trial):
Caffeine significantly reduced the incidence of bronchopulmonary dysplasia (BPD) and improved neurodevelopmental outcomes in preterm infants.

Dobson NR et al., Pediatrics (2014):
Early caffeine administration within 2 days of birth reduced the duration of mechanical ventilation and oxygen support.

Eichenwald EC et al., AAP Guidelines (2016):
Recommended caffeine citrate as first-line pharmacologic treatment for apnea of prematurity.

FAQs – Cafcit Syrup (Caffeine Citrate)
Q1: What is Cafcit used for in newborns?
Cafcit is used to stimulate breathing in premature infants suffering from apnea of prematurity.

Q2: Is Cafcit the same as regular caffeine?
No. Cafcit is a pharmaceutical-grade citrate salt of caffeine, specifically designed for neonatal use.

Q3: How is Cafcit administered?
Orally or via nasogastric tube using a calibrated syringe, typically once a day.

Q4: Is Cafcit safe for long-term use in infants?
Yes, when used under specialist guidance, it is well tolerated. Long-term studies (CAP Trial) show positive neurodevelopmental outcomes.

Q5: Can Cafcit be given at home?
Only under strict neonatal follow-up. Typically, it is administered in hospital/NICU settings.
Store at 15–30°C (59–86°F)

Protect from excessive heat or freezing

Use within the expiry period after opening

Buy Cafcit Syrup Online at EZ Chemist
At EZ Chemist, we provide genuine Cafcit Oral Solution with pharmacist support. For neonatal units, pediatricians, and hospitals, we offer bulk and emergency shipment options.

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