Cardura (Doxazosin) – Trusted Relief for High Blood Pressure and BPH
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What is Cardura used for
Cardura (Doxazosin) is a prescription medication used to treat high blood pressure (hypertension) and benign prostatic hyperplasia (BPH). It works by relaxing blood vessels and the muscles in the prostate and bladder neck, making it easier to urinate and lowering blood pressure.
Brand Name: Cardura

Generic Name: Doxazosin mesylate

Strengths Available: 1 mg, 2 mg, 4 mg, 8 mg

Form: Oral tablet

Drug Class: Alpha-1 Adrenergic Blocker

Prescription Status: Prescription-only medication (Rx)

Manufacturer: Pfizer
Doxazosin mesylate

This selective alpha-1 adrenergic receptor antagonist helps reduce blood pressure and improve urinary flow in men with enlarged prostates.
Generic Equivalents: Doxazosin

Other Brand Names:

Doxadura

Doxacard

Cardulex

Duracard

Atenurax
Cardura selectively blocks alpha-1 adrenergic receptors in vascular smooth muscle and the prostate:

For Hypertension: Relaxes blood vessels, allowing blood to flow more easily, thereby lowering blood pressure.

For BPH: Relaxes the smooth muscles of the bladder neck and prostate, improving urine flow and reducing symptoms such as urgency and incomplete emptying.
Essential Hypertension (High Blood Pressure)

Benign Prostatic Hyperplasia (BPH)

May also be used off-label for ureteric stones, Raynaud’s disease, and heart failure (as part of combination therapy)
For Hypertension:
Initial dose: 1 mg once daily

Maintenance dose: 2–4 mg once daily

Maximum dose: 16 mg/day
Initial dose: 1 mg once daily

Titrate to 2–8 mg/day based on response

Take at bedtime to minimize first-dose hypotension

Administration Tips:

Swallow tablet whole with water

Can be taken with or without food

Monitor blood pressure regularly
Start with the lowest dose (1 mg) to prevent orthostatic hypotension

Dose adjustment may be needed based on renal or hepatic function

Regular PSA testing recommended for BPH patients
Pregnancy Category: C (Not recommended unless necessary)

Lactation: Excreted in small amounts; caution advised

Driving: Avoid until the patient knows how it affects them

Elderly: Increased sensitivity to hypotension
Common Less Common / Serious
Dizziness, fatigue Fainting (especially after first dose)
Headache Hypotension
Nasal congestion Priapism (rare, prolonged erection)
Edema Liver enzyme abnormalities
Retrograde ejaculation (BPH) Palpitations, chest pain
First-dose hypotension: Risk of severe drop in BP after initial dose or dose escalation

Avoid abrupt withdrawal – may cause rebound hypertension

Hepatic impairment: Use with caution

Eye surgery: Risk of Intraoperative Floppy Iris Syndrome (IFIS) during cataract surgery

Syncope risk: Especially with alcohol or dehydration
Pharmacologic Class: Alpha-1 Adrenergic Receptor Blocker

ATC Code: C02CA04

Legal Category: Prescription only (Rx)

Pregnancy Category: C (Australia/US)
Interacting Drug Effect / Risk
PDE5 inhibitors (e.g., Sildenafil) Increased risk of hypotension
Other antihypertensives Additive hypotensive effect
Beta-blockers Potentiation of BP-lowering effect
NSAIDs May reduce antihypertensive efficacy
CYP3A4 inhibitors (e.g., ketoconazole) May increase doxazosin levels
NEJM (1995): Demonstrated effective blood pressure reduction in monotherapy and combination therapy

AUA Guidelines (2021): Alpha blockers like Cardura remain first-line treatment for BPH

PREDICT Trial (2001): Showed doxazosin significantly improved urinary symptoms in BPH patients

Frequently Asked Questions (FAQs)
Q1: How long does Cardura take to work?
Blood pressure may begin to reduce within a few hours of the first dose. BPH symptoms often improve within 1–2 weeks.

Q2: Can Cardura be used for both hypertension and BPH?
Yes, Cardura is indicated for both conditions and may be prescribed for patients with both high blood pressure and an enlarged prostate.

Q3: Is Cardura safe for long-term use?
Yes, Cardura has been proven safe and effective for long-term management of both hypertension and BPH when monitored by a healthcare provider.

Q4: Can I take Cardura with food?
Yes, Cardura can be taken with or without food. Taking it at the same time each day helps maintain consistent blood levels.

Q5: Can women take Cardura?
While primarily used in men for BPH, Cardura may be prescribed to women for hypertension. However, it is not typically used in pregnancy.
Store at below 30°C

Protect from light and moisture

Keep in original packaging

Keep out of reach of children

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