Comprehensive Product Description Guide: Catapress (Clonidine Hydrochloride)

What is Catapress used for
Catapress (Clonidine Hydrochloride) is a prescription medication used to treat high blood pressure (hypertension). It works by stimulating alpha-2 adrenergic receptors in the brain, reducing nerve signals that tighten blood vessels, thereby lowering blood pressure.
Catapress 100 mcg Tablets
Also available as: Catapres-TTS (transdermal patches) in some regions (not always available in AU)
Clonidine Hydrochloride
Catapres

Dixarit (used in some countries for ADHD and menopausal flushing)

Kapvay (extended-release version for ADHD in US)

Clonidine Hydrochloride (generic name)

Therapeutic Class: Antihypertensive

Pharmacological Class: Centrally Acting Alpha-2 Adrenergic Agonist

ATC Code: C02AC01

Schedule: Prescription-Only Medicine (S4 in Australia)
Clonidine acts on the central nervous system by stimulating alpha-2 adrenergic receptors in the brain stem. This leads to a reduction in sympathetic nerve signals, resulting in:

Lowered heart rate

Relaxation of blood vessels

Decreased blood pressure

Additionally, its sedative and pain-modulating effects allow use in withdrawal syndromes and ADHD (off-label in some countries).
Catapress is primarily indicated for:

Essential hypertension (high blood pressure)

Hypertensive crises (short-term control)

Off-label or adjunctive uses include:

ADHD (especially in children with sleep disturbances)

Menopausal hot flashes

Opioid and alcohol withdrawal

Tourette’s syndrome

Restless leg syndrome (RLS)

Smoking cessation (adjunct)
Adult Hypertension:
Starting dose: 50–100 mcg twice daily

Maintenance: 100–300 mcg twice daily (max: 600 mcg/day)

Doses should be titrated gradually

Paediatric ADHD (off-label in AU):
Initiated at 25 mcg once daily at bedtime, adjusted by response

Requires specialist oversight
Dose reduction may be needed due to renal excretion

Note: Do not discontinue Catapress abruptly. Taper slowly over 2–4 days to prevent rebound hypertension.

Prescribing & Administration Information:
Administer orally with or without food

Take at the same time daily to maintain stable blood levels

Tablet may be split if necessary

Monitor blood pressure and heart rate regularly
Avoid abrupt withdrawal

Not recommended in severe bradycardia or depressive disorders without monitoring

Use caution in elderly patients, those with renal impairment, and depression
Dry mouth

Drowsiness, sedation

Constipation

Dizziness or fatigue

Bradycardia

Less Common / Serious Side Effects:

Rebound hypertension (on sudden withdrawal)

Hypotension

Mood changes, depression

Allergic rash

Nightmares or vivid dreams
Do not stop Catapress suddenly – tapering is essential

May impair mental alertness – caution with machinery or driving

Use cautiously in patients with depression, heart block, or severe coronary artery disease

Regular blood pressure and renal function monitoring is recommended
Beta-blockers (e.g., atenolol): May increase bradycardia; withdraw beta-blocker before Catapress tapering

CNS depressants: Sedatives, opioids, or alcohol may enhance drowsiness

TCAs or MAOIs: May reduce antihypertensive effect

Other antihypertensives: Additive effects; monitor closely
Store below 25°C

Keep in original packaging to protect from moisture

Keep out of reach of children
Prisant LM et al. (1991, American Journal of Hypertension): Clonidine shown effective in reducing blood pressure with minimal long-term organ damage

Biederman J et al. (2008, Pediatrics): Adjunctive use of clonidine in ADHD reduced hyperactivity and improved sleep patterns

Gold MS et al. (1994, Drug and Alcohol Dependence): Effective in managing symptoms of opiate withdrawal

Joffe H et al. (2000, Obstetrics & Gynecology): Clonidine reduced hot flashes in menopausal women with preserved cardiovascular safety

Frequently Asked Questions (FAQs)
Q: What is Catapress used for?
A: Catapress is prescribed for managing high blood pressure. It may also be used off-label for ADHD, withdrawal symptoms, menopausal flushing, and more.

Q: Can Catapress be used for sleep problems?
A: Yes, Catapress has sedative properties and is sometimes prescribed off-label for sleep issues, particularly in ADHD patients.

Q: How long does Catapress take to work?
A: Effects begin within 30–60 minutes, with peak action in 2–4 hours. Long-term blood pressure control is seen over weeks.

Q: Is Catapress addictive?
A: No, it is not habit-forming, but sudden withdrawal may cause serious rebound hypertension.

Q: Can Catapress be used during pregnancy?
A: Use in pregnancy is not routinely recommended. It may be considered if the benefits outweigh the risks and only under specialist care.

Q: What happens if I miss a dose?
A: Take it as soon as you remember unless it’s close to the next dose. Never double up.

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