Ceclor (Cefaclor)
Compared with: Blackmores Conceive Well Gold 28 Tablets + 28 Capsules

Ceclor (Cefaclor) 250 mg, 500 mg capsules is a second‑generation cephalosporin antibiotic that inhibits bacterial cell‑wall synthesis. Indicated for respiratory tract, skin, and urinary tract infections, Ceclor offers broad‑spectrum activity, including many β‑lactamase–producing strains, with a safety profile suitable for adults and children.
Cefaclor – 250 mg or 500 mg per capsule; 125 mg/5 mL and 250 mg/5 mL oral suspension.
Generic: Cefaclor

Synonyms: β‑Lactam antibiotic, second‑generation cephalosporin

Alternate Formulations: Ceclor CD® (extended‑release 375 mg), Ceclor® pediatric suspension
Cefaclor binds to penicillin‑binding proteins (PBPs) on the bacterial cell membrane, inhibiting the final transpeptidation step of peptidoglycan synthesis. This weakens the cell wall, leading to osmotic lysis and bactericidal activity against susceptible Gram‑positive and Gram‑negative organisms.

Upper Respiratory Tract Infections: Pharyngitis, tonsillitis, sinusitis

Lower Respiratory Tract Infections: Acute bacterial exacerbations of chronic bronchitis, community‐acquired pneumonia

Otitis Media: Acute middle‐ear infections in pediatric patients

Skin and Soft Tissue Infections: Impetigo, cellulitis, wound infections

Urinary Tract Infections: Uncomplicated cystitis in women
Indication Adult Dose Pediatric Dose Frequency
Pharyngitis/Tonsillitis 250–500 mg every 8 hours 20 mg/kg/day divided every 8 h 3 times daily
Otitis Media 250 mg every 8 hours 40 mg/kg/day divided every 8 h 3 times daily
Acute Bronchitis / Pneumonia 500 mg every 8 hours 40–60 mg/kg/day divided every 8 h 3 times daily
Skin & Soft Tissue Infections 250–500 mg every 8 hours 20 mg/kg/day divided every 8 h 3 times daily
Uncomplicated UTI 250 mg every 8 hours 20 mg/kg/day divided every 8 h 3 times daily

Administration: Capsules swallowed whole; suspension shaken well.

Food Effect: Can be taken without regard to meals.

Missed Dose: Take as soon as remembered; do not double the next dose.
Formulations: Capsules, extended‐release tablets, oral suspension

Strengths: 250 mg, 500 mg capsules; 375 mg extended‐release; 125 mg/5 mL, 250 mg/5 mL suspension

Route: Oral

Legal Status: Prescription Only Medicine
Pregnancy: Category B – No evidence of harm in animal studies; use only if clearly needed.

Breastfeeding: Excreted in breast milk; monitor infant for diarrhea and candidiasis.

Pediatric Use: Approved for children ≥6 months; weight‐based dosing essential.

Renal Impairment: Reduce dose or extend interval if creatinine clearance <30 mL/min.
Diarrhea, nausea, vomiting

Rash, urticaria

Headache

Vaginitis

Serious (rare):

Clostridioides difficile–associated diarrhea

Stevens–Johnson syndrome, toxic epidermal necrolysis

Anaphylaxis in β‑lactam–sensitive patients

Hepatotoxicity (transient enzyme elevations)

Warnings & Cautions
Allergy Alert: Contraindicated in patients with history of severe hypersensitivity to cephalosporins or penicillins.

Superinfection: Prolonged use may result in overgrowth of non‑susceptible organisms; monitor.

C. difficile Risk: Discontinue if severe diarrhea occurs and evaluate.

Seizure Risk: High doses in renal failure may lower seizure threshold.
Therapeutic Class: Antibiotic

Pharmacologic Class: Second‑Generation Cephalosporin

Legal Category: Prescription Only
Probenecid: Inhibits renal tubular secretion of cefaclor, increasing serum levels.

Aminoglycosides: Concurrent use may increase nephrotoxicity; monitor renal function.

Oral Contraceptives: Diarrhea may reduce absorption—use backup contraception.

Anticoagulants: Altered vitamin K–producing flora may affect INR; monitor coagulation.
Comparative trials demonstrate cefaclor’s non‑inferiority to amoxicillin‑clavulanate in acute otitis media and sinusitis, with fewer gastrointestinal side effects.

Meta‑analyses show clinical cure rates of 80–90 % in respiratory tract infections with 250–500 mg TID regimens.

FAQs – Ceclor (Cefaclor)
Q1. How soon does Ceclor work?
A: Symptom improvement often within 48–72 hours; complete eradication requires full course.

Q2. Can I take Ceclor with food?
A: Yes. Food does not significantly affect absorption.

Q3. What if I miss a dose?
A: Take as soon as remembered; if close to the next dose, skip—do not double.

Q4. Is Ceclor safe for children?
A: Yes, from 6 months old with weight‑based dosing.

Q5. Can Ceclor cause diarrhea?
A: Yes. Consider probiotic support if diarrhea occurs; discontinue if severe.

Q6. Does Ceclor interact with dairy?
A: No significant interaction; dairy does not impair absorption.

Q7. Can I switch to Ceclor CD extended‑release?
A: Yes—375 mg once daily provides similar exposure and convenience.
Ceclor, Cefaclor, Second‑Generation Cephalosporin, Respiratory Tract Antibiotic, Otitis Media Treatment, Skin Infection Therapy, EZ Chemist, Urinary Tract Infection Drug, Cefaclor Dosage Guide, Antibiotic FAQ