Cefadroxil 500mg / 1g Capsules – Broad-Spectrum Oral Antibiotic
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What is Cefadroxil used for
Cefadroxil is a broad-spectrum first-generation cephalosporin antibiotic used to treat bacterial infections such as tonsillitis, skin infections, urinary tract infections, and soft tissue infections. It works by stopping bacterial cell wall synthesis.

Generic Name: Cefadroxil

Brand Names: Duricef, Cefadrox

Drug Class: First-generation cephalosporin antibiotic

Strengths: 250 mg, 500 mg, 1 g

Formulation: Oral capsules/tablets, suspension

Availability: Prescription Only (Rx)

Storage: Store at below 25°C, away from moisture

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Cefadroxil Monohydrate
Cefadroxil is a semisynthetic cephalosporin with antibacterial activity, chemically related to cephalexin.

Duricef (brand by Bristol-Myers Squibb)

Cefadrox, Roxil (marketed in various countries)

First-generation cephalosporin
Cefadroxil works by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs), preventing the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, leading to cell lysis and death.

Bactericidal action

Effective against Gram-positive cocci and some Gram-negative bacilli

Stable in acid; suitable for oral use
Cefadroxil is indicated for the treatment of infections caused by susceptible organisms:

Upper Respiratory Tract Infections

Tonsillitis, pharyngitis

Skin and Soft Tissue Infections

Cellulitis, impetigo, wound infections

Urinary Tract Infections (UTIs)

Cystitis, pyelonephritis

Other off-label uses (at physician’s discretion):

Prophylaxis in dental infections

Bone and joint infections
Adults:
Skin or throat infections:
500 mg to 1 g every 12 hours for 7–10 days

1 g every 12 hours for 7–10 days

Children:
30 mg/kg/day in two divided doses

Adjust for weight and clinical severity

Take with or without food

Complete full course even if symptoms improve

Dosage may need adjustment in renal impairment
Confirm bacterial cause before use

Not effective against viral infections (e.g., colds or flu)

Take with a full glass of water

Space doses evenly throughout the day
Pregnancy Category B: Safe when prescribed by a physician

Lactation: Present in breast milk in small amounts; consult healthcare provider

Renal Impairment: Dose adjustment required

Driving: No specific restrictions, but may cause dizziness in some patients
Common Side Effects Serious Side Effects
Diarrhoea, nausea, vomiting Severe allergic reactions (anaphylaxis)
Abdominal pain Clostridium difficile-associated diarrhoea
Rash, itching Seizures (in renal impairment, rare)
Headache, fatigue Blood disorders (rare)
Allergy warning:
Patients allergic to penicillins or other cephalosporins may be cross-sensitive

Antibiotic-associated colitis risk:
Report persistent diarrhoea to physician
Long-term use may result in overgrowth of non-susceptible organisms

Renal function monitoring:
Recommended in elderly or those with kidney disease

Drug Interactions
Interacting Agent Effect/Risk
Probenecid Increases cefadroxil serum concentration
Loop diuretics, aminoglycosides Increased nephrotoxicity risk
Antacids (Al/Mg-based) May reduce absorption slightly
Warfarin Enhanced anticoagulant effect (rare)

Drug Classification
Pharmacologic Class: Cephalosporin Antibiotic

ATC Code: J01DB05

Schedule: Prescription Only Medication (Rx)

Clinical Evidence & Efficacy
Tonsillitis/pharyngitis: Cefadroxil is as effective as penicillin V in treating streptococcal infections (source: Pediatrics, 1981)

Skin infections: Multiple studies confirm its equivalence to first-line antibiotics in treating MSSA and S. pyogenes

UTI treatment: Effective against E. coli, Proteus mirabilis, and Klebsiella pneumoniae (clinical efficacy above 85%)

Frequently Asked Questions (FAQs)
Q1: Is Cefadroxil safe in pregnancy?
Yes, Cefadroxil is considered safe in pregnancy (Category B) but should be used under medical supervision.

Q2: How long does Cefadroxil take to work?
Improvement in symptoms is usually noticed within 2–3 days of starting treatment, though the full course must be completed.

Q3: Can Cefadroxil be taken with food?
Yes. Cefadroxil can be taken with or without food. Food may help reduce stomach upset.

Q4: What should I do if I miss a dose?
Take the missed dose as soon as remembered. If it's close to the next dose, skip the missed one. Do not double dose.

Q5: Is Cefadroxil the same as Cephalexin?
They are both first-generation cephalosporins with similar action, but not identical. Dosing and pharmacokinetics vary slightly.
Store below 25°C

Keep tightly closed and protected from light/moisture

Keep out of reach of children

Reconstituted suspensions must be refrigerated and used within 14 days
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