Celebrex 200mg Capsules – Selective COX-2 Anti-inflammatory Pain Relief

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What is Celebrex used for
Celebrex (Celecoxib) is a prescription nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation in conditions like osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and menstrual pain. It selectively inhibits COX-2 enzymes, offering pain relief with reduced gastrointestinal side effects.

Brand Name: Celebrex

Generic Name: Celecoxib

Drug Class: COX-2 Selective Nonsteroidal Anti-inflammatory Drug (NSAID)

Available Strengths: 100mg, 200mg

Formulation: Oral Capsules

Availability: Prescription Only (Rx)

Manufacturer: Pfizer Inc.

Storage: Store below 25°C in a dry place

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Celecoxib
A selective COX-2 inhibitor that reduces pain and inflammation by blocking the enzyme responsible for prostaglandin synthesis without significantly affecting COX-1, which protects the stomach lining.

Other Popular Names / Synonyms
Celecoxib (Generic Name)

Selective COX-2 inhibitor

Branded generics: Cobix, Oncocare, Rheumacox (varies by country)

Celebrex selectively inhibits the cyclooxygenase-2 (COX-2) enzyme, reducing the production of prostaglandins involved in pain and inflammation. Unlike traditional NSAIDs, it spares COX-1, thus causing fewer gastrointestinal side effects such as ulcers or bleeding.
Osteoarthritis – Reduces joint pain, stiffness, and swelling

Rheumatoid Arthritis – Controls chronic joint inflammation

Ankylosing Spondylitis – Improves spinal flexibility and reduces pain

Acute Pain – Effective for backache, dental, and musculoskeletal pain

Primary Dysmenorrhea – Relieves menstrual cramps

Juvenile Rheumatoid Arthritis (JRA) – In patients aged 2 years and above
Adults:
Condition Recommended Dose
Osteoarthritis 200mg once daily or 100mg twice daily
Rheumatoid Arthritis 100–200mg twice daily
Acute Pain or Menstrual Pain 400mg initially, then 200mg if needed
Ankylosing Spondylitis 200mg once daily or 100mg twice daily

Children (JRA):
50–100mg twice daily (based on weight and age; for children ≥2 years)
Take with or without food

Swallow whole with water

Do not exceed 400mg/day
Always start with the lowest effective dose for the shortest duration

Assess cardiovascular and gastrointestinal risk prior to prescribing

Renal and hepatic function should be monitored periodically
Pregnancy Category D (3rd trimester): Avoid use

Lactation: Excreted in breast milk; consult doctor

Geriatrics: Use with caution; increased risk of CV events

Driving/Operating Machinery: May cause dizziness or drowsiness
Common Serious
Indigestion, heartburn GI bleeding, ulcers
Headache Myocardial infarction, stroke
Dizziness, flatulence Liver dysfunction, renal impairment
Hypertension Anaphylaxis (rare)
Rash, photosensitivity Stevens-Johnson Syndrome (rare)
May increase risk of heart attack or stroke, especially with long-term use or in patients with pre-existing heart conditions.
Though lower than traditional NSAIDs, risk of GI bleeding still exists.

Renal and Hepatic Impairment:
Adjust dosage and monitor function during therapy.

Sulfonamide allergy

Severe hepatic impairment

Advanced renal disease

Pregnancy in third trimester
Interacting Drug Clinical Effect
Warfarin Increased bleeding risk (monitor INR)
ACE inhibitors/Diuretics Reduced renal function
Fluconazole Increases celecoxib plasma concentration
Lithium Elevated lithium levels
Antihypertensives May reduce efficacy
ATC Code: M01AH01

Class: Selective COX-2 Inhibitor, NSAID

Legal Status: Schedule H (Rx only in most countries)

Prescription Required: Yes
CLASS Trial (2000): Demonstrated lower GI complications vs ibuprofen and diclofenac.

PRECISION Trial (2016): No increased CV risk compared to naproxen or ibuprofen in high-risk patients.

Cochrane Review (2020): Effective in managing osteoarthritis and rheumatoid arthritis pain with reduced GI events.

FAQs – Frequently Asked Questions
Q1. What is Celebrex used to treat?
Celebrex is used to treat arthritis-related inflammation, acute pain, menstrual cramps, and ankylosing spondylitis.

Q2. Is Celebrex safer for the stomach than other NSAIDs?
Yes. It selectively inhibits COX-2, sparing COX-1, which protects the stomach lining, thereby reducing the risk of ulcers.

Q3. Can Celebrex be taken long term?
It can be used long term under medical supervision. Regular monitoring is recommended for cardiovascular, liver, and kidney health.

Q4. Can Celebrex be taken with food?
Yes. Taking Celebrex with food may reduce the risk of stomach upset.

Q5. Is Celebrex addictive or a steroid?
No. Celebrex is non-addictive and not a corticosteroid. It is a non-steroidal anti-inflammatory drug (NSAID).
Store below 25°C

Protect from light and moisture

Keep out of reach of children

Do not use expired medication

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