Chantix / Champix (Varenicline Tartrate) – Prescription Smoking Cessation Aid
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What is Champix (Chantix) used for
Champix (also sold as Chantix) is a prescription medication containing varenicline, used to help adults quit smoking. It works by reducing cravings and withdrawal symptoms while also blocking nicotine's pleasurable effects in the brain.

Brand Names: Champix (UK), Chantix (USA)

Generic Name: Varenicline Tartrate

Drug Class: Nicotinic Acetylcholine Receptor Partial Agonist

Formulation: Film-coated oral tablets

Available Strengths: 0.5 mg and 1 mg tablets

Pack Sizes: Starter Pack (11 x 0.5 mg + 42 x 1 mg)

Route of Administration: Oral

Prescription Required: Yes

Manufacturer: Pfizer Inc.

Availability: Generic versions may be available

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Varenicline Tartrate
Each tablet contains varenicline tartrate equivalent to either 0.5 mg or 1 mg of varenicline base. It is a selective partial agonist at the α4β2 nicotinic acetylcholine receptor.

Varenicline

Generic Champix / Chantix

Smoking cessation tablet

Quit smoking pill

Varenicline binds with high affinity to the α4β2 nicotinic acetylcholine receptors in the brain, providing a dual mechanism:

Partial Agonist Activity – Reduces nicotine withdrawal symptoms by mildly stimulating dopamine release.

Antagonist Activity – Blocks nicotine from binding to these receptors, thereby reducing the pleasurable effects of smoking.

This action reduces cravings and withdrawal symptoms and prevents relapse by diminishing the rewarding aspects of smoking.

Champix / Chantix is indicated for:

Smoking cessation in adults aged 18 years and older

May be used in conjunction with behavioral support programs

Shown to be more effective than bupropion or nicotine replacement therapy (NRT) alone

Dosage and Administration
Treatment Duration: 12 Weeks (with optional 12-week extension)

Starter Pack (Days 1–14):

1–3 0.5 mg once daily
4–7 0.5 mg twice daily
8+ 1 mg twice daily

Maintenance (Weeks 2–12):
Continue with 1 mg twice daily after meals.

Optional: Patients who successfully quit may benefit from another 12-week course to prevent relapse.
Choose a quit date within 1–2 weeks of starting treatment.

Swallow tablets whole with water after food.

Tapering is not required upon discontinuation.

May be continued longer in patients at high risk of relapse.

Safety Information
Pregnancy Category C: Use only if clearly needed; limited human data available.

Lactation: Caution advised; excretion in breast milk unknown.

Pediatrics: Not approved for use in patients under 18 years.

Geriatrics: No dosage adjustment necessary unless renal impairment is present.
Common Serious
Nausea (most common) Suicidal ideation or behavior (rare)
Insomnia Severe skin reactions (Stevens-Johnson)
Abnormal dreams Cardiovascular events in at-risk patients
Headache Agitation, depression
Flatulence, dry mouth Hypersensitivity reactions
Neuropsychiatric Events: Monitor for depression, aggression, suicidal thoughts. Discontinue if symptoms occur.

Cardiovascular Risk: May increase risk in patients with cardiovascular disease. Use caution.

Seizures: Reported in some patients; use caution in seizure-prone individuals.

Alcohol Interaction: May increase risk of altered behavior or blackout.

Driving Impairment: May cause dizziness or sleepiness.

Interacting Drug/Class Interaction Details
Nicotine Replacement Therapy (NRT) May increase side effects like nausea
Alcohol May intensify neuropsychiatric side effects
Warfarin INR monitoring recommended
Insulin May alter glycemic control after quitting
Cimetidine (in renal impairment) Increases varenicline levels

Varenicline is minimally metabolized by the liver and does not significantly affect CYP450 enzymes.

ATC Code: N07BA03

Therapeutic Class: Smoking Cessation Aid

Legal Classification: Prescription Only

Schedule: Not classified as a controlled substance

Clinical Studies and Efficacy
Jorenby DE et al. (JAMA 2006):
Varenicline significantly improved abstinence rates compared to bupropion and placebo at 12 and 24 weeks.

Tonstad S et al. (Ann Intern Med 2006):
12-week maintenance therapy doubled abstinence rates compared to placebo.

Cochrane Review 2021:
Varenicline was found to be 2–3 times more effective than placebo and more effective than bupropion.

Frequently Asked Questions (FAQs)
Q1. What is Champix (Chantix) used for?
Champix is used to help adults stop smoking by reducing cravings and withdrawal symptoms and blocking nicotine's pleasurable effects.

Q2. How long does it take for Champix to work?
Most patients begin to notice reduced cravings within the first week. Maximum effect is seen after 2–4 weeks.

Q3. Can I smoke while taking Champix?
Yes, during the first week. Choose a quit date within 1–2 weeks of starting and aim to stop smoking entirely by that date.

Q4. What if I miss a dose?
Take it as soon as you remember. Skip if it’s close to the next dose. Do not double the dose.

Q5. Is nausea common with Champix?
Yes, it is the most frequently reported side effect. Taking it with food and water may reduce nausea.

Q6. Can I take Champix with other stop-smoking aids?
It is usually taken alone. Combining with NRT may increase side effects and should be done only under medical advice.

Storage Instructions
Store at room temperature below 25°C

Protect from moisture and light

Keep out of reach of children

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