Cisafluk (Fluconazole) – Versatile Antifungal Oral Medication
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What is Cisafluk used for
Cisafluk (fluconazole) is a prescription antifungal medication used to treat a variety of yeast and fungal infections, including vaginal yeast infections, oral thrush, esophageal candidiasis, systemic candidiasis, and cryptococcal meningitis. It works by inhibiting fungal cell membrane synthesis.

Brand Name: Cisafluk

Generic Name: Fluconazole

Drug Class: Triazole Antifungal Agent

Available Strengths: 50 mg, 100 mg, 150 mg, 200 mg, 400 mg

Formulations: Oral tablets and suspension; some regions offer injectable form

Prescription Status: Prescription-only medication (Rx)

Manufacturer/Distributor: Various licensed pharmaceutical companies

Fluconazole – A triazole antifungal that inhibits ergosterol synthesis by blocking fungal cytochrome P450 enzyme 14α‑demethylase, leading to impaired cell membrane integrity and fungistatic or fungicidal effects

Diflucan (Pfizer brand)

Generic Fluconazole

Triazole Antifungal

Oral Antifungal Tablet

Candida Treatment Pill

Fluconazole selectively inhibits fungal 14α-demethylase, preventing ergosterol formation—a critical component of fungal cell membranes. This results in increased permeability and inhibition of fungal growth, with preferential action on fungal cells over human cells

Cisafluk is indicated for treatment and prevention of:

Vaginal candidiasis (yeast infection)

Oropharyngeal and esophageal candidiasis (thrush)

Urinary tract and systemic candidiasis

Cryptococcal meningitis

Prophylaxis in immunocompromised patients, such as bone marrow transplant recipients
Mayo Clinic

Vaginal yeast infection: Single-dose 150 mg tablet

Oropharyngeal/esophageal candidiasis: 200 mg on day 1, then 100 mg daily for 2–6 weeks

Systemic infections or cryptococcal meningitis: 400 mg daily; some regimens start with loading dose of 800 mg

Urinary tract infections: 50–200 mg daily based on severity

Based on weight, e.g., for thrush: loading dose 6 mg/kg, then 3 mg/kg daily; higher dosing for systemic infections

Take with or without food; consistent fluid intake recommended.

Confirm diagnosis where possible (e.g., fungal culture before treatment)

Adjust dose in renal impairment (CrCl <50 mL/min); typical reduction ≈50%

Monitor liver function during prolonged or high-dose therapy

QT-prolonging medications: Use cautiously; fluconazole can further extend QT interval
Mayo Clinic

Pregnancy category: D at high doses; avoid during pregnancy unless essential

Breastfeeding: Excreted in breast milk; weigh benefits vs. risks

Pediatric Use: Approved for infants and children with appropriate dosing
Mayo Clinic
Elderly: Lower doses advised due to reduced renal clearance

Common Serious
Headache, nausea, abdominal pain Hepatotoxicity (elevated liver enzymes)
Diarrhea, dysgeusia, rash QT prolongation, arrhythmias
Dizziness Anaphylaxis, Stevens–Johnson syndrome
Increased liver enzymes Seizures (rare)

Hepatotoxicity: Monitor liver enzymes; discontinue if serious

QT-prolonging drugs: Avoid combinations with cisapride, pimozide, quinidine

Allergies: Contraindicated in patients with prior hypersensitivity to fluconazole or other azoles

Alcohol use: Avoid due to added risk of liver injury

Fluconazole is a CYP3A4/2C9/2C19 inhibitor. Notable interactions include:
DrugBank

Warfarin: Increased INR, bleeding risk

Statins (atorvastatin, simvastatin): Increased muscle and liver toxicity

Antidiabetics (e.g., sulphonylureas): Risk of hypoglycaemia

Anticonvulsants (e.g., phenytoin, carbamazepine): Varying effects on levels

QT-prolonging drugs: Additive risk—avoid concomitant use

ATC Code: J02AC01

Therapeutic Class: Antifungal – Triazole

Legal Status: Prescription-only (Rx)

WHO Essential Medicine: Yes
WebMD

Clinical Evidence and Efficacy
Diflucan approval (FDA, 1990) based on trials showing high efficacy in thrush, vaginal infections, and cryptococcal meningitis

Meta-analyses confirm single-dose fluconazole (150 mg) cures 80–90% of vaginal candidiasis cases

Pediatric trials show safe and effective treatment in infants with thrush and systemic candidiasis
Mayo Clinic

FAQs – Cisafluk (Fluconazole)
Q1: What infections can Cisafluk treat?
Treats yeast infections (vaginal, oral, esophageal), urinary candidiasis, systemic fungal and cryptococcal meningitis, and prevents fungal infections in immunocompromised patients.

Q2: Is one dose enough for yeast infections?
Yes. A single 150 mg dose typically resolves uncomplicated vaginal yeast infections. Additional dosing may be required if symptoms persist.

Q3: Can I drink alcohol while on Cisafluk?
Avoid alcohol during and one week after treatment to reduce liver strain and symptom severity.

Q4: Is Cisafluk safe during pregnancy?
Avoid during pregnancy unless treating a life-threatening infection; higher doses have teratogenic risks.

Q5: What should I do if I miss a dose?
Take the missed dose as soon as possible. If it’s near your next scheduled dose, skip it and continue the regular schedule. Do not double-dose.

Store at room temperature (below 25 °C)

Keep in original packaging, away from moisture and light

Keep out of reach of children

Discard suspension after 14 days per label instructions

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