Comprehensive Product Description Guide: Claforan Injection (Cefotaxime Sodium Injection)

What is Claforan Injection used for
Claforan Injection (Cefotaxime) is a third-generation cephalosporin antibiotic used to treat severe bacterial infections including pneumonia, urinary tract infections, skin and soft tissue infections, sepsis, and meningitis. It works by inhibiting bacterial cell wall synthesis, leading to bacterial cell death.

Claforan Injection
Generic Name: Cefotaxime Sodium
Brand Names: Claforan, Cefotax
Drug Class: Third-generation Cephalosporin Antibiotic
Formulation: Powder for injection (IV or IM use)
Available Strengths: 500 mg, 1 g, 2 g vials

Cefotaxime Sodium
Each vial of Claforan Injection contains sterile cefotaxime sodium equivalent to 500 mg, 1 g, or 2 g of cefotaxime.

Cefotaxime

Claforan IV injection

Cefotaxime injection USP

Broad-spectrum cephalosporin antibiotic

Cefotaxime is a β-lactam cephalosporin antibiotic that works by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs), disrupting the final stage of peptidoglycan synthesis, resulting in cell lysis and death of susceptible bacteria.

Claforan is used to treat moderate to severe infections caused by susceptible bacteria, including:

Lower respiratory tract infections (e.g., pneumonia)

Urinary tract infections (UTIs)

Skin and soft tissue infections

Bacterial meningitis

Gynecological infections (e.g., pelvic inflammatory disease)

Septicemia (sepsis)

Intra-abdominal infections (e.g., peritonitis)

Post-operative infections

Gonorrhoea (alternative treatment)

Bone and joint infections (e.g., osteomyelitis)

Dosage and Administration:
Route: Intravenous (IV) or Intramuscular (IM) injection

Usual dose: 1–2 g every 8 hours IV or IM depending on severity

Severe infections: Up to 12 g per day in divided doses

Pediatric dosing:

Neonates (≤7 days): 50 mg/kg every 12 hours

Infants and children: 50–180 mg/kg/day divided every 6–8 hours

Preparation:
Reconstitute with sterile water for injection or appropriate diluent as per product insert. Use immediately after preparation or store refrigerated for up to 24 hours.

Prescription-Only Medicine (S4 in Australia)

Must be administered under medical supervision

Dose adjustment needed in renal impairment

Contraindications:

Hypersensitivity to cephalosporins or penicillins

Severe allergic reaction to beta-lactam antibiotics

Use in Pregnancy:

Category B1 (no known risk in humans based on animal studies)

Present in breast milk; caution advised

Common Side Effects:

Diarrhoea

Rash

Injection site reactions (pain, swelling)

Nausea

Serious Adverse Reactions:

Anaphylaxis

Clostridioides difficile-associated diarrhoea

Blood dyscrasias (e.g., leukopenia, thrombocytopenia)

Hepatotoxicity

Seizures (in renal failure or overdose)

Use caution in patients with penicillin allergy due to potential cross-sensitivity

Monitor renal function during prolonged therapy

Risk of superinfection with prolonged use

Not for use in viral infections (e.g., influenza)

Aminoglycosides: Increased risk of nephrotoxicity

Loop diuretics: May enhance nephrotoxicity

Probenecid: Delays renal excretion, increasing cefotaxime levels

May interfere with urinary glucose tests

Clinical Evidence and Efficacy:
Randomized controlled trials confirm the efficacy of cefotaxime in serious infections including neonatal sepsis and bacterial meningitis

CDC & WHO Guidelines: Cefotaxime is considered a key antibiotic for hospital-acquired infections

Lancet Infectious Diseases (2020): Effective in multi-drug resistant infections when used with sensitivity testing

FAQs:
Q: What is Claforan injection used for?
A: Claforan is used to treat serious bacterial infections like pneumonia, sepsis, meningitis, and complicated UTIs.

Q: Can Claforan be used in children?
A: Yes, cefotaxime is frequently used in pediatric infections under medical supervision with weight-based dosing.

Q: Is Claforan safe during pregnancy?
A: Classified as Pregnancy Category B1. It is considered relatively safe when clearly indicated.

Q: How long does it take for Claforan to work?
A: Symptom relief typically begins within 24–48 hours, but the full course must be completed to prevent resistance.

Q: Can it be mixed with other antibiotics?
A: Compatibility depends on the agent. Never mix in the same IV line unless confirmed safe.

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