Clarinex (Desloratadine) – Non-Drowsy Antihistamine for Allergy Relief

What is Clarinex used for
Clarinex (Desloratadine) is a once-daily, second-generation antihistamine used to treat seasonal and perennial allergic rhinitis and chronic idiopathic urticaria (hives). It relieves symptoms like sneezing, runny nose, itchy or watery eyes, and skin rashes without causing drowsiness.

Brand Name: Clarinex

Generic Name: Desloratadine

Form: Film-coated tablet (5 mg); oral solution/red-tabs also available historically

Drug Class: Second-generation H₁ antihistamine

Prescription Status: Rx-only

Manufacturer: Schering‑Plough / Organon (original patent); many generic manufacturers now available

Order Clarinex 5mg Tablet – EZ Chemist Pharmacy

Desloratadine 5 mg (the primary active metabolite of loratadine)

Mechanism: A selective tricyclic H₁ receptor inverse agonist that blocks histamine release, alleviating allergy symptoms without sedation

Aerius (Canada/EU)

Generic Desloratadine

Clarinex‑D (combo with pseudoephedrine)

Desloratadine works by:

Blocking peripheral H₁ receptors, reducing histamine-mediated allergy symptoms (e.g., sneezing, itchy eyes)
ScienceDirect

Having minimal central nervous system penetration, leading to little to no sedation
MedicineNet

Onset: Within 1 hour; duration: Up to 24 hours

Seasonal allergic rhinitis (≥ 2 years)

Perennial allergic rhinitis (≥ 6 months)

Chronic idiopathic urticaria (hives) (≥ 6 months)

Symptom relief includes sneezing, runny or blocked nose, itchy/watery eyes, and hives
Mayo Clinic

Age Group Dose
Adults & adolescents (≥ 12 yr) 5 mg once daily (tablet/RediTabs)

Children 6–11 yr 2.5 mg once daily (oral solution or 2.5 mg RediTab)

DailyMed
Children 6–60 mo 1.25 mg daily (oral solution)

DailyMed
Infants 6–11 mo 1 mg once daily (oral solution)
DailyMed
Renal/hepatic impairment 5 mg every other day
MPR

Administration: With or without meals; tablets swallowed whole, RediTabs dissolve on tongue

Contraindications: Hypersensitivity to desloratadine or loratadine
ScienceDirect

Precautions:

Contains sulfites – caution in asthma

Use with care in renal or hepatic impairment

Not indicated < 6 months old

Common (>2 %):
Headache, dry mouth, fatigue, somnolence, pharyngitis, myalgia, dysmenorrhea
MPR

Severe allergic reactions, tachycardia, arrhythmias, blurred vision, neurological events such as confusion or seizures
RxList
MedicineNet

CNS: Minimal sedation but dizziness may occur
MedicineNet
WebMD

Cardiac: Rare cases of tachyarrhythmia and QT prolongation—monitor if risk factors present
RxList
MedicineNet

Asthma: Sulfite sensitivity may exacerbate bronchospasm

Moderate interactions:

CYP3A4 inhibitors (ketoconazole, erythromycin, azithromycin, cimetidine, fluoxetine) – may increase Clarinex levels
WebMD

Hypersensitivity — interactions with allergen extracts
Mild additive CNS depression with alcohol—though no clear evidence of interaction
WebMD

ATC Code: R06AX27

Pharmacologic Class: Second-generation H₁ antihistamine

Legal Status: Prescription-only (Rx)

Schedule: Not a controlled substance

Pregnancy/Lactation: Limited data; use only if benefits outweigh risks

Onset & duration: Effective symptom relief within 1 hour, lasting ≥ 24 hours

Comparative efficacy: Comparable to cetirizine and fexofenadine with reduced sedation due to low CNS penetration

FAQ
Q1. How fast does Clarinex work?
Onset is within one hour; full daily relief lasts about 24 hours

Q2. Will Clarinex make me drowsy?
It’s minimally sedating, though some users report mild tiredness or dizziness
MedicineNet
WebMD
Q3. Can children take Clarinex?
Yes—appropriate dosing for children aged 6 months to 11 years is available in oral solution
Drugs.com
DailyMed

Q4. Is Clarinex safe with liver or kidney problems?
Use with reduced frequency (every other day) in patients with moderate to severe hepatic or renal impairment
DailyMed

Q5. Is Clarinex better than Claritin or Zyrtec?
It is equally effective but often preferred for its longer half-life (~27 h) and lower sedation risk due to limited CNS penetration

Q6. Can I drink alcohol while taking it?
Though no direct interactions are noted, alcohol may increase the risk of dizziness or sedation
WebMD

Store at 15–30 °C, protected from moisture and light
DailyMed

Keep in original packaging

Keep out of reach of children

Buy Clarinex Online – EZ Chemist Pharmacy
EZ Chemist ensures authentic Clarinex 5 mg tablets, including oral solution for pediatric use. Benefits include fast shipping, pharmacist consultation, and reliable sourcing.

Order Clarinex 5 mg Tablets – EZ Chemist
Explore Allergy Relief Medications – EZ Chemist

Clarinex online India, Desloratadine allergy medicine, buy non-drowsy antihistamine, Clarinex 5mg price, pediatric antihistamine syrup, hives treatment Clarinex, prescription allergy tablet India