Comprehensive Product Description Guide: Cleocin Gel (Clindamycin Phosphate Topical Gel)

What is Cleocin Gel used for
Cleocin Gel, containing clindamycin phosphate, is a topical antibiotic used to treat acne vulgaris by reducing skin bacteria and inflammation. It helps decrease the number and severity of acne lesions.

Cleocin Gel (Clindamycin Phosphate Topical Gel 1%)

Clindamycin Phosphate 1% w/w

Equivalent to approximately 10 mg clindamycin per gram of gel.

Clindamycin Gel

Clindamycin Phosphate Topical

Cleocin T Gel

Generic Clindamycin 1% Gel

Clindagel

Therapeutic Class: Lincosamide Antibiotic

Prescription Status: Prescription-only medication (Rx)

Clindamycin is a lincosamide antibiotic that works by inhibiting bacterial protein synthesis. It binds to the 50S ribosomal subunit of Propionibacterium acnes (now known as Cutibacterium acnes), thereby reducing bacterial load and inflammation within sebaceous follicles. It also exhibits anti-inflammatory effects on the skin, contributing to acne control.

Cleocin Gel is indicated for the topical treatment of acne vulgaris, particularly:

Mild to moderate inflammatory acne

Papulopustular acne

Comedonal acne (in combination with retinoids)

May be used as adjunct therapy in severe acne regimens

Route: Topical (external use only)

Apply a thin film to the affected area once or twice daily as directed by a healthcare provider.
Cleanse and pat dry the skin before application.

Apply a thin layer of Cleocin Gel to the entire affected area.
Avoid contact with eyes, mouth, and mucous membranes.
Wash hands after application.
Treatment Duration:
Results typically visible after 2–6 weeks; maximum benefit seen after 8–12 weeks of continuous use.

Available in 30g or 60g tubes or pump dispensers
Store below 25°C; do not freeze
For external use only; not for ophthalmic or vaginal use

Avoid excessive sun exposure during treatment

Hypersensitivity to clindamycin, lincomycin, or any gel component

History of antibiotic-associated colitis or Clostridium difficile-associated diarrhea
Avoid use on broken, sunburned, or eczematous skin
Use with caution in patients with gastrointestinal diseases
Monitor for signs of colitis (e.g., prolonged or bloody diarrhea) during prolonged use

Common Side Effects:
Dryness or peeling of the skin

Erythema (redness)

Burning or stinging sensation

Pruritus (itching)

Less Common but Serious Effects:
Diarrhea (systemic absorption)

Abdominal cramps

Signs of Clostridium difficile colitis (rare but serious)

Risk of antibiotic resistance: Do not use longer than prescribed

Photosensitivity: Use sunscreen to reduce risk of sunburn

Avoid concurrent use of multiple topical acne products unless directed

Not suitable for treating rosacea, fungal infections, or non-bacterial acne

Pregnancy Category B: Animal studies have not shown harm; use only if clearly needed

Caution advised in breastfeeding

Avoid concurrent use with erythromycin due to antagonistic effect

Risk of enhanced irritation when used with topical retinoids, salicylic acid, or benzoyl peroxide

Minimal systemic absorption, but caution when combined with oral clindamycin or lincomycin due to increased risk of pseudomembranous colitis

Clinical Backing:
Journal of Dermatology (2018): Clindamycin topical monotherapy significantly reduced inflammatory lesions in mild to moderate acne.

Clinical Therapeutics (2016): Combined clindamycin and benzoyl peroxide therapies improved outcomes and reduced resistance.

AAD Guidelines: Clindamycin is recommended as a core component of topical acne therapy, especially when used with benzoyl peroxide to prevent resistance.

FAQs
Q: Can Cleocin Gel be used with other acne treatments?
A: Yes, it can be combined with benzoyl peroxide or topical retinoids under medical supervision. Avoid layering without direction due to irritation risk.

Q: How long does Cleocin Gel take to work?
A: Visible improvement typically begins in 2–6 weeks, with full benefits observed after 8–12 weeks of use.

Q: Can it cause dry or irritated skin?
A: Yes, some users may experience mild skin irritation, especially in the first few weeks of use.

Q: Is it safe during pregnancy or breastfeeding?
A: Cleocin Gel is Pregnancy Category B. It is generally considered safe during pregnancy but should be used only when necessary.

Q: What should I do if I develop diarrhea while using Cleocin Gel?
A: Discontinue use and consult your healthcare provider immediately, as this could be a sign of colitis, a rare but serious side effect.

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