Combivent® Inhaler – Dual Bronchodilator for COPD Management

Buy Combivent Inhaler (Ipratropium + Albuterol) for COPD

What is Combivent inhaler used for?
Combivent Inhalation Aerosol combines ipratropium bromide and albuterol sulfate to provide dual-action bronchodilation for chronic obstructive pulmonary disease (COPD). It helps relieve bronchospasm by relaxing airway smooth muscle via both anticholinergic and β₂-adrenergic mechanisms.

Brand Name: Combivent®

Generic Name: Ipratropium Bromide + Albuterol (Salbutamol)

Drug Class: Short-acting β₂-agonist + Anticholinergic bronchodilator

Formulation: Pressurized metered-dose inhaler (MDI) or Respimat®

Typical Dose per Actuation: 18 µg ipratropium + 90 µg albuterol base (MDI) 
FDA Access Data

Excipients: HFA propellants, soy lecithin (MDI) 

Prescription Status: Rx only

Packaging: 200-dose canister with mouthpiece; Respimat cartridge with 120 puffs

Ipratropium Bromide: Anticholinergic bronchodilator (Atrovent®) 

Albuterol Sulfate (Salbutamol): Selective short-acting β₂-agonist 
Curex

Common Alternatives: Duoneb (solution for nebulizer), Combivent Respimat

Ipratropium Bromide: Blocks parasympathetic (muscarinic M3) receptors in airway smooth muscle to reduce bronchoconstriction 
Medical News Today

Albuterol: Stimulates β₂-adrenergic receptors, increasing cAMP, relaxing airway smooth muscle 

These complimentary actions enhance bronchodilation more than either agent alone 
FDA Access Data

Approved for patients with COPD (chronic bronchitis or emphysema) already using an inhaled bronchodilator but still experiencing bronchospasm 

Provides rapid relief (onset ~15 min) and duration of effect ~4–5 hours 

Not a rescue inhaler for acute asthma attacks

Dosage & Administration
Metered-Dose Inhaler (MDI): 1–2 puffs 4 times a day (~90 µg albuterol/18 µg ipratropium per puff) 
Medical News Today

Respimat Inhaler: 1 puff of 100 µg albuterol + 20 µg ipratropium QID (max 6/day) 
Medical News Today
FDA Access Data

Patients should shake MDI before use, prime before first use or after 24 hours, and rinse mouth post-inhalation

Safety & Prescribing Precautions
Contraindications: Allergy to soy/peanut components or atropine derivatives 

Paradoxical bronchospasm—discontinue if occurs 

Cardiovascular risk—use cautiously in patients with arrhythmia, ischemia, or hypertension 
JAMA Network

CNS stimulation—caution in hyperthyroidism, seizure disorders, diabetes 

Anticholinergic caution in narrow-angle glaucoma and prostatic hyperplasia 
RxList

Storage: Avoid heat/flame; do not puncture canister; store upright in cool temperature 

Tremor, headache, palpitations, tachycardia, nervousness (β₂-agonist effects) 

Dry mouth, throat irritation (anticholinergic effects) 

Rare: paradoxical bronchospasm, urinary retention, increased intraocular pressure, allergic reactions 

Drug Interactions
Additive cardiovascular effects with other β-agonists, sympathomimetics, diuretics, MAO inhibitors 

Additive anticholinergic effects with other muscarinic agents (e.g., oxybutynin) 

Caution when used with antidiabetics and hypokalemia-inducing drugs (e.g., non-potassium-sparing diuretics) 
Drug Classification
ATC Code: R03AK04

Therapeutic Class: Short-acting β₂-agonist + anticholinergic bronchodilator

Prescription Status: Rx only; not scheduled

Clinical Evidence
12-week RCTs (n≈1,067) showed superior FEV₁ improvement compared to monotherapy 

COPD Trials (Chest, 1994): Combination provided more effective bronchodilation than ipratropium or albuterol alone, especially in first 4 hours post-dose 
RxList

Respimat data: Comparable or improved lung response with Respimat device vs MDI formulation 
Medical News Today
FDA Access Data
pro.boehringer-ingelheim.com

Frequently Asked Questions (FAQs)
Q1. Who should use Combivent?
Patients with COPD who still experience bronchospasm despite single-agent bronchodilator therapy 

Q2. How fast does it work and for how long?
Effect begins in ~15 minutes; peak effect occurs at ~1 hour and lasts approximately 4–5 hours 

Q3. Can I use it more than 4 times a day?
Maximum recommended frequency is 4 times daily. Do not exceed dosage unless directed by a healthcare provider 
Medical News Today
Q4. Is it safe for patients with glaucoma or prostate issues?
Use cautiously; avoid spraying into eyes. Monitor for urinary retention and increased intraocular pressure 
RxList

Q5. Can I combine it with my steroid inhaler?
Yes. Combivent is often used with inhaled corticosteroids or theophylline. Monitor for additive side effects 
Drugs.com
American Journal of Medicine
Curex

Q6. How should I store and prime it?
Keep inhaler upright in a cool place, avoid heat. Prime before first use or if unused for >24 hours (shake MDI, spray 3 times) 

At EZ Chemist Online Pharmacy, we offer genuine Combivent Inhalers and Respimat devices with full product support and discreet shipping. Consult our pharmacists if you need training or have specific health concerns.

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