Compazine (Prochlorperazine)

What is Compazine used for
Compazine, also known by its generic name Prochlorperazine, is a prescription medication primarily used to treat severe nausea and vomiting, schizophrenia, and anxiety. It works by altering the effects of dopamine in the brain. Compazine is commonly available in tablet, suppository, and injectable forms and is classified under phenothiazine antipsychotics. Consult a healthcare provider for proper dosage and usage.

Compazine (Prochlorperazine)

Not applicable for Blackmores Conceive Well Gold – separate product listing provided below.

Prochlorperazine Maleate

Other Common & Brand Names:
Generic: Prochlorperazine

Brand Names: Stemetil, Buccastem, Compro, Phenotil

Therapeutic Class: Phenothiazine Derivative Antiemetic and Antipsychotic

Prochlorperazine is a dopamine (D2) receptor antagonist. It works by blocking dopamine receptors in the brain, particularly in the chemoreceptor trigger zone (CTZ), which reduces feelings of nausea and vomiting. In psychiatric uses, its dopamine-inhibiting activity in the mesolimbic system helps alleviate psychotic symptoms like delusions and hallucinations.

Uses of Compazine (Prochlorperazine):
Compazine is used for a wide range of clinical conditions including:

Severe Nausea and Vomiting (including that caused by chemotherapy or surgery)

Schizophrenia and Psychotic Disorders

Anxiety Management (short-term use)

Vertigo and Migraine-Associated Nausea

Non-psychotic agitation

Note: Not intended for prophylactic use in motion sickness unless prescribed.

Indication Typical Adult Dosage
Severe nausea and vomiting 5–10 mg orally, 3–4 times daily
Schizophrenia 5–10 mg orally, up to 4 times daily; max 150 mg/day
Anxiety 5 mg orally, 3–4 times daily
Suppository Form (for emesis) 25 mg rectally twice daily

Pediatric Dosing: Must be individualized by a pediatric specialist.
Elderly Patients: Use lower starting doses due to increased risk of extrapyramidal symptoms and sedation.

Formulations Available:
Oral Tablets, Rectal Suppositories, Intramuscular/Intravenous Injection

Prescription Required:
Yes

Within 30–60 minutes orally; faster with IM/IV administration

Common Side Effects:
Drowsiness, dizziness

Dry mouth, blurred vision

Constipation, weight gain

Extrapyramidal Symptoms (tremor, dystonia, restlessness)

Tardive Dyskinesia (involuntary movements)

Neuroleptic Malignant Syndrome (NMS)

Jaundice or liver function abnormalities

Hypotension

Report any side effects to your healthcare provider immediately.

Black Box Warning: Increased mortality risk in elderly patients with dementia-related psychosis

Pregnancy & Breastfeeding: Use only if benefits outweigh risks (Pregnancy Category C)

Avoid alcohol and CNS depressants while taking this medication

Use caution in patients with liver impairment, glaucoma, Parkinson's disease, or seizure disorders

CNS Depressants (e.g., opioids, benzodiazepines): Additive sedation

Antihypertensives: Enhanced hypotensive effect

Levodopa: Antagonistic effects

Lithium: Risk of neurotoxicity when combined

Anticholinergic drugs: Increased risk of dry mouth, blurred vision

Clinical Evidence:
A 2014 meta-analysis published in BMJ confirmed Prochlorperazine’s efficacy in treating nausea, especially post-operative and chemotherapy-induced. Additional studies in JAMA Psychiatry support its role in managing schizophrenia with fewer extrapyramidal effects at low doses.

Drug Classification:
Therapeutic Class: Antiemetic / Antipsychotic

Pharmacologic Class: Phenothiazine

ATC Code: N05AB04

Store at room temperature (15°C – 30°C)

Protect from moisture and direct sunlight

Keep out of reach of children

Frequently Asked Questions (FAQ)
Q: Is Compazine the same as Stemetil?
A: Both contain Prochlorperazine but are marketed under different brand names. Formulation may differ slightly depending on country and manufacturer.

Q: Can Compazine be used for migraines?
A: Yes, especially when migraines are accompanied by severe nausea. It is often prescribed for this dual action.

Q: How long does Compazine stay in your system?
A: The half-life ranges between 4–8 hours, but clinical effects may last longer depending on the dose and route of administration.

Q: Is it habit-forming?
A: No, Compazine is not addictive or habit-forming but should be used as directed by a physician.

Q: Can I drive while taking Compazine?
A: Avoid driving or operating machinery until you know how the medicine affects you. Drowsiness is a common side effect.

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