Coreg (Carvedilol) – Complete Product Guide for EZ Chemist Online Pharmacy

What is Coreg used for
Coreg (Carvedilol) is a prescription beta-blocker used to treat high blood pressure, heart failure, and to improve survival after a heart attack. It works by relaxing blood vessels and slowing heart rate to improve blood flow and reduce workload on the heart. Available in immediate and extended-release forms, Coreg is commonly prescribed as part of long-term cardiovascular therapy.

Coreg (Carvedilol)

Packaging:
Available in tablet forms: 3.125 mg, 6.25 mg, 12.5 mg, and 25 mg

Carvedilol

Generic Name: Carvedilol

Brand Names: Coreg, Coreg CR (Controlled Release)

Also Known As (INN/USAN): Carvedilolum

Coreg is a non-selective beta-adrenergic blocker and alpha-1 blocker.

Beta-blocking activity: Slows heart rate and reduces myocardial oxygen demand

Alpha-blocking activity: Vasodilation, lowering blood pressure
This dual action improves left ventricular function and reduces cardiac workload in heart failure and hypertension.

Uses of Coreg (Carvedilol):
FDA-Approved Indications:
Hypertension (High Blood Pressure)

Congestive Heart Failure (CHF)

Left Ventricular Dysfunction Post-Myocardial Infarction (Heart Attack)

Off-Label Uses (Clinically Supported):
Atrial fibrillation with rapid ventricular response (RVR)

Portal hypertension in liver disease

Migraine prophylaxis (in selected cases)

Condition Initial Dose Maintenance Dose
Hypertension 6.25 mg twice daily Up to 25 mg twice daily
Heart Failure (Mild to Moderate) 3.125 mg twice daily Up to 25 mg or 50 mg twice daily (by weight)
Post-Myocardial Infarction (LVD) 6.25 mg twice daily Titrate to max 25 mg twice daily

Pediatric Use: Safety and efficacy not established
Geriatric Use: Start at lower doses and titrate cautiously

Prescription Required: Yes

Route of Administration: Oral

Onset of Action: 1–2 hours (peak plasma concentration)

Half-life: 7–10 hours (IR); 10–13 hours (CR)

Side Effects of Coreg (Carvedilol):
Common Side Effects:
Fatigue

Dizziness or lightheadedness

Bradycardia (slow heart rate)

Hypotension

Weight gain and fluid retention (especially in CHF)

Worsening of heart failure

Bronchospasm (especially in asthmatics)

Hepatic dysfunction

Stevens-Johnson syndrome (rare)

Severe bradycardia or AV block

Do Not Discontinue Abruptly: May lead to angina or myocardial infarction

Bronchospastic Disease: Use with caution

Diabetes: May mask hypoglycemia symptoms

Hepatic Impairment: Dose adjustment needed

Pregnancy: Category C – use only if benefits outweigh risk

Lactation: Avoid use; insufficient data on excretion in breastmilk

Calcium Channel Blockers (e.g., Verapamil, Diltiazem): Risk of bradycardia or heart block

CYP2D6 Inhibitors (e.g., Fluoxetine, Paroxetine): May increase plasma levels of Carvedilol

Insulin & Oral Antidiabetics: Enhanced hypoglycemic effect and masked symptoms

Digoxin: Increased serum digoxin levels

Anesthetics: Enhanced cardiovascular depressive effect

The COPERNICUS trial confirmed a significant reduction in mortality in patients with severe heart failure on Carvedilol.

The CAPRICORN trial supported its efficacy in improving survival after myocardial infarction.

Pharmacologic Class: Beta-blocker (non-selective), Alpha-1 blocker

Therapeutic Class: Antihypertensive / Heart Failure Agent

ATC Code: C07AG02

Store below 25°C in a dry place

Protect from moisture and light

Keep out of reach of children

Frequently Asked Questions (FAQ)
Q: What is the difference between Coreg and Coreg CR?
A: Coreg CR is the extended-release formulation that allows once-daily dosing, while Coreg (IR) is taken twice daily.

Q: Can Coreg cause weight gain?
A: Yes, fluid retention and weight gain can occur, especially in patients with heart failure. Inform your doctor if this happens.

Q: How long does Coreg take to work?
A: Some effects, such as lowered heart rate, may appear within hours, but full therapeutic benefits for blood pressure or heart failure may take several weeks.

Q: Is Coreg safe in asthma patients?
A: Use caution. Non-selective beta-blockers can cause bronchospasm and are generally avoided in patients with asthma.

Q: Can Coreg be crushed or split?
A: Immediate-release tablets may be split (if scored). Coreg CR capsules should not be crushed or chewed.

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