Covera‑HS® SR (Verapamil) – Bedtime Extended‑Release Calcium Channel Blocker

Buy Covera‑HS SR (Verapamil) Online – One‑Daily Treatment for Hypertension & Angina
Covera‑HS SR is a once-daily, bedtime extended-release verapamil capsule. It controls high blood pressure and treats angina by gradually releasing the drug overnight to cover the early morning surge in blood pressure, ensuring 24‑hour efficacy.

Brand Name: Covera‑HS® SR

Generic Name: Verapamil hydrochloride (extended‑release)

Drug Class: Non-dihydropyridine calcium channel blocker; Class IV antiarrhythmic

Form: 180 mg & 240 mg sustained-release capsules (osmotic, delayed-release)

Use: Oral, once daily at bedtime

Prescription Status: Rx-only

Manufactured: Multiple generic manufacturers

Order Covera‑HS® SR – EZ Chemist Pharmacy
Verapamil hydrochloride, racemic mixture of R/S isomers 

Alternate brands: Calan SR, Isoptin SR, Verelan, Verelan PM 

Blocks L-type calcium channels in vascular smooth muscle and cardiac tissue

Causes arterial vasodilation, reduces afterload, lowers blood pressure

Exhibits negative chronotropic and dromotropic effects (AV node conduction delay), useful in angina and arrhythmia 
NCBI
FDA Access Data

Hypertension – solo or combination therapy

Chronic stable angina and vasospastic (Prinzmetal’s) angina

Supraventricular arrhythmias (e.g., atrial fibrillation/flutter) – rate control (off-label)

Occasionally used off-label for cluster headache prevention at ≥240 mg daily 
FDA Access Data
Initial dose: 180 mg at bedtime

Titration: Increase to 240 mg → 360 mg → up to 480 mg as needed 
RxList

Administration tips: Swallow whole with food or as evening dose; do not chew or crush 
RxList

Special populations: Elderly initiate at 120 mg; hepatic impairment requires dose reduction due to delayed metabolism 

Safety & Prescribing Guidelines
Contraindications: Severe hypotension (SBP <90 mmHg), cardiogenic shock, significant left ventricular dysfunction, second/third-degree AV block without pacemaker, known hypersensitivity 
NCBI

Use cautiously in bradycardia, heart failure, hepatic impairment 
Medscape Reference

Avoid abrupt withdrawal in arrhythmia patients

Avoid grapefruit juice due to CYP3A4 inhibition and elevated verapamil exposure 
Medscape Reference

Common (>5%): Constipation, headache, dizziness, flushing, nausea, edema 

Less common: Bradycardia, heart block, hypotension, gingival hyperplasia, mood changes 

Serious: Heart failure exacerbation, severe hypotension, AV block—monitor for these 

Cardiac monitoring advised in patients with heart failure or conduction issues

Hepatic impairment: dose reductions necessary

Grapefruit interaction: may significantly increase blood levels 
Mayo Clinic

Avoid rapid posture changes to reduce dizziness; caution when driving until tolerance established 

CYP3A4 substrates/inhibitors: Increases levels of simvastatin, lovastatin, cyclosporine, many statins, some antifungals—monitor and adjust 
Medscape Reference

Beta-blockers, digoxin: Additive AV block/bradycardia risk—monitor ECG

Other antihypertensives: Additive hypotension risk

Horse‑dangerous combos: Contraindicated with dantrolene (hyperkalemia) 

Medscape Reference

ATC code: C08DA01

Therapeutic class: Calcium channel blocker – non-dihydropyridine

Medicinal status: Prescription only, not controlled

Clinical Evidence
Two 8‑week SA/DB trials (n = 382) confirmed dose-dependent 24‑h BP reduction with Covera‑HS vs placebo 

Demonstrated improvements in exercise tolerance and angina symptoms at ≥360 mg 
RxList

Evidence supports bedtime dosing to blunt morning BP surge and reduce cardiovascular risk 
PMC

Frequently Asked Questions (FAQs)
Q1. Why take Covera-HS at bedtime?
Designed to release verapamil 4–5 h after ingestion, targeting early morning BP peaks and ensuring all‑day blood pressure control 
RxList

Q2. Can I split or crush the capsule?
No. Covera‑HS is osmotic-release; slicing the capsule destroys the delivery mechanism and alters dosing 
FDA Access Data
MedlinePlus
Medscape Reference

Q3. Can it treat arrhythmias?
Yes. Verapamil is used for rate control in atrial fibrillation, SVT, and off-label for cluster headaches (up to 480 mg/day) 

Q4. Will it cause constipation?
It commonly slows GI motility, leading to constipation in ~7% of patients. Increase fiber and fluid intake to reduce risk 
Wikipedia
RxList
Q5. Can I drink grapefruit juice?
No. It inhibits breakdown of verapamil, increasing drug levels and risk of side effects 

Store at 20–25 °C in original container with desiccant

Protect from moisture and sunlight

Keep out of reach of children
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