Cozaar (Losartan Potassium) – First-line ARB for Hypertension & Nephroprotection

Buy Cozaar (Losartan) Online – Treat Hypertension & Diabetic Nephropathy | EZ Chemist Pharmacy
Cozaar (losartan) is an angiotensin II receptor blocker (ARB) prescribed to lower blood pressure, reduce stroke risk in hypertension with left ventricular hypertrophy, and slow kidney disease progression in type 2 diabetes. Cozaar works by relaxing blood vessels and promoting sodium excretion.
Brand Name: Cozaar
Generic Name: Losartan Potassium
Drug Class: Angiotensin II Receptor Blocker (ARB)
Formulation: Oral tablets (25 mg, 50 mg, 100 mg); oral suspension in some markets ([turn0search4], [turn0search12])

Prescription Status: Rx only

Available in: India via imports/generics
Order Cozaar 50 mg/100 mg – EZ Chemist
Losartan Potassium – generic equivalent to Cozaar
Other brand variations: Arbli, Hyzaar (losartan + HCTZ), Ocsaar Plus ([turn0search25], [turn0search4])
Losartan is a selective antagonist of the angiotensin II type 1 (AT₁) receptor. It reduces vasoconstriction, aldosterone secretion, sympathetic activation, sodium retention, and vascular/anatomical hypertrophy ([turn0search3], [turn0search23], [turn0search24]). Additionally, losartan has a mild uricosuric effect by inhibiting URAT1 in renal tubules ([turn0search23]).

Hypertension in adults and children ≥6 years to reduce cardiovascular morbidity and mortality ([turn0search13], [turn0search4])
Stroke risk reduction in hypertensive patients with left ventricular hypertrophy (LIFE trial) ([turn0search4], [turn0search7], [turn0search19])
Diabetic nephropathy: Slows progression in type 2 diabetes with proteinuria ([turn0search12], [turn0search1])
Off-label for Marfan syndrome and other orphan indications ([turn0search4])
Adults (hypertension): Start 50 mg once daily, titrate to 100 mg once daily as needed. If fluid-depleted or on diuretics, begin at 25 mg daily ([turn0search4], [turn0search12])
Pediatrics ≥6 years: 0.7 mg/kg daily (max 50 mg), titrate based on response ([turn0search12])

Liver compromise: Initiate at 25 mg daily in mild-to-moderate hepatic impairment ([turn0search12])
Administration: May be taken with or without food. Tablets swallow whole; suspension (if available) prepared per instructions ([turn0search12])
Baseline lab check: Serum potassium, creatinine, eGFR, especially with concurrent diuretics or CKD
Periodic monitoring: Electrolytes and renal function in high-risk patients
Contraindications: Pregnancy, breastfeeding, bilateral renal artery stenosis, use with aliskiren in diabetes, known hypersensitivity ([turn0search13], [turn0search6], [turn0search26])

Pregnancy risk: Category D (US); ARBs are teratogenic—discontinue immediately if pregnancy detected ([turn0search13], [turn0search6])
Common (≥1%):

Dizziness, lightheadedness, headache, back pain, cough, nasal congestion, diarrhea, fatigue, upper respiratory infections ([turn0search8], [turn0search10], [turn0search12], [turn0search26])

Hyperkalemia, renal impairment (especially if volume-depleted or with NSAIDs), hypotension, angioedema, hepatotoxicity, neutropenia, hyponatremia, vasculitis, rare liver injury ([turn0search26], [turn0search2], [turn0search12])

Hypotension: Occurs especially after the first dose; caution with diuretics or volume depletion

Renal impairment: Can worsen in renal artery stenosis; monitor renal function

Angioedema: Discontinue immediately if symptoms occur

Hyperkalemia risk: Especially when combined with potassium-sparing agents, supplements, or in renal dysfunction patients

NSAIDs: May worsen renal function and blunt antihypertensive effects

Lithium: Losartan may raise lithium levels—monitor and adjust lithium dosing

Aliskiren use in diabetes: Contraindicated due to increased risk of hypotension, hyperkalemia, and renal failure ([turn0search4], [turn0search25])

Potassium supplements, potassium-sparing diuretics: Increased risk of hyperkalemia ([turn0search14], [turn0search25])

NSAIDs: May reduce antihypertensive effect; increase renal risk

Lithium: Increases lithium toxicity risk

Rifampin, phenytoin, carbamazepine: May reduce losartan levels and efficacy ([turn0search24])

Other RAAS agents (ACE inhibitors, ARBs, aliskiren): Additive hypotensive and renal adverse effects—monitor closely

ATC Code: C09CA01 (ARB, plain)

Therapeutic Class: Antihypertensive (ARB)
Prescription Status: Rx only
IDNT Study (NEJM 2001): Losartan reduced renal outcomes in type 2 diabetic nephropathy by 25% vs placebo ([turn0search1])
LIFE Trial: Losartan superior to atenolol for reducing stroke risk in hypertensives with LVH ([turn0search7], [turn0search19])
Dose-comparison RCTs: 50–150 mg showed dose-dependent BP reduction comparable to enalapril 20 mg ([turn0search5])
Frequently Asked Questions (Q&A)
Q1. How quickly does Cozaar lower blood pressure?
Effect begins within 1 hour, peak at 6 hours, lasts ~24 hours; full effect typically seen within 3–6 weeks of use.

Q2. Is losartan safe for diabetics?
Yes—it's proven to protect kidneys in type 2 diabetes with proteinuria and reduce progression to severe renal disease ([turn0search1], [turn0search12]).

Q3. Can I use it with a diuretic or ACE inhibitor?
Yes—but monitor blood pressure, electrolytes, and kidney function due to increased risk of hypotension and renal impairment.

Q4. What if I become pregnant?
Stop immediately and inform your physician. ARBs can cause fetal harm; alternative BP management is essential ([turn0search13], [turn0search6]).

Q5. Can I drink coffee or alcohol?
Moderate coffee intake has no long-term BP impact; alcohol may worsen hypotension—consume cautiously ([turn0news21], [turn0search2]).

Q6. What to do if I miss a dose?
Take the dose as soon as remembered unless it's almost time for the next dose. Do not double the dose.

Store at 20–25 °C, away from heat, moisture, and light

Keep tablets in original packaging until use

Keep out of reach of children

EZ Chemist offers genuine Cozaar (Losartan Potassium) tablets with authentic packaging, pharmacist support, secure shipping, and lab monitoring guidance.

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