Cytosar-U (Cytarabine Injection) – Comprehensive Product Description
Pack Combo: Includes Blackmores Conceive Well Gold 28 Tablets + 28 Capsules

Cytosar-U (Cytarabine) is a chemotherapy injection used to treat blood cancers such as acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), and non-Hodgkin’s lymphoma. It works by interfering with the growth of cancer cells, leading to their destruction.

Cytosar-U Injection 100 mg/mL (Cytarabine)
Paired With: Blackmores Conceive Well Gold, a leading fertility and preconception support supplement.

Cytarabine (also known as Ara-C)
Cytarabine

Ara-C

Cytosine arabinoside

Cytosar

Cytosar-U

Cytarabine injection for leukemia

Cytarabine is a pyrimidine antimetabolite. It inhibits DNA synthesis by competing with cytosine nucleotides during the S-phase of the cell cycle. It gets incorporated into DNA and RNA and prevents the replication of rapidly dividing cells, especially cancerous white blood cells.

Therapeutic Indications (Uses):
Cytosar-U is indicated for:

Acute myeloid leukemia (AML) – treatment and induction therapy

Acute lymphoblastic leukemia (ALL)

Chronic myeloid leukemia (blast phase)

Non-Hodgkin’s lymphoma

Meningeal leukemia or lymphoma (intrathecal use)

CNS prophylaxis in leukemia
Cytosar-U is given via intravenous (IV), subcutaneous (SC), or intrathecal (IT) routes.

Use Typical Dosage
Induction AML therapy 100–200 mg/m² IV daily for 7 days
High-dose consolidation 2–3 g/m² IV every 12 hours on specific days
Intrathecal for CNS leukemia 5–30 mg based on age and protocol

Must be administered in hospital or oncology center

Always under supervision of an oncologist or hematologist

Dosage adjusted based on renal/hepatic function and blood counts
Form: Injectable solution

Strength: 100 mg/mL (available in 1 mL to 10 mL vials)

Route: IV, SC, or IT

Prescription Required: Yes (strictly regulated cytotoxic drug)

Storage: Refrigerate at 2–8°C. Protect from light.
Requires regular CBC monitoring

Monitor for signs of infection, bleeding, and neurologic toxicity

Concomitant fertility supplement (e.g. Conceive Well Gold) not to be taken during chemotherapy cycles unless approved by oncologist

Ensure contraceptive use during and up to 6 months after chemotherapy
Nausea, vomiting, diarrhea

Fever, chills, infection risk due to neutropenia

Mucositis (mouth sores)

Hepatic dysfunction

Rash, local injection site reactions

Cerebellar toxicity (ataxia, slurred speech) at high doses

Bone marrow suppression (pancytopenia)
Cytotoxic agent – use only under oncologist supervision

Not to be used in pregnancy – teratogenic and embryotoxic

Avoid during conception planning – male and female patients must use contraception

Not compatible with most multivitamins or fertility supplements during therapy

Avoid in severe hepatic or renal impairment without specialist advice
Drug Interaction
Live vaccines Increased risk of severe infection
Digoxin Absorption may be impaired by cytarabine
Other chemotherapeutic agents Risk of additive toxicity (e.g., methotrexate)
Blackmores Conceive Well Gold Should be paused during chemotherapy

Note: Restart fertility supplements like Blackmores Conceive Well Gold after completion of chemotherapy with medical advice.

CALGB 8525 Trial: Showed that high-dose cytarabine improves disease-free survival in AML patients under 60

NEJM 1994 & Blood Journal 2010: Supported intrathecal use of cytarabine for CNS prophylaxis

EORTC trials: Combined cytarabine with daunorubicin or idarubicin for remission in AML patients
ATC Code: L01BC01

Pharmacologic Class: Antimetabolite, Antineoplastic

WHO Essential Medicines List: Included

Schedule: S4 or higher (varies by country – cytotoxic handling required)

Storage Instructions:
Refrigerate (2–8°C)

Do not freeze

Use only clear, colorless solution

Dispose safely following cytotoxic handling protocol

Frequently Asked Questions (FAQs):
Q: Can Cytosar-U be taken with Blackmores Conceive Well Gold?
No. Cytosar-U is a chemotherapy drug. Fertility supplements like Conceive Well Gold should be stopped during chemotherapy and resumed only after completing treatment under the direction of a healthcare provider.

Q: Is Cytosar-U safe in pregnancy or breastfeeding?
No. Cytarabine is contraindicated in pregnancy due to risk of congenital abnormalities and fetal toxicity. Contraception must be used during treatment and for 6 months after.

Q: How is Cytarabine administered?
Cytarabine is administered as an injection into the vein (IV), under the skin (SC), or into the spinal fluid (intrathecal) depending on cancer type and stage.

Q: How long does Cytarabine stay in the body?
The half-life of standard-dose Cytarabine is short (10 minutes), but high-dose or intrathecal forms have prolonged systemic effects.

Q: What precautions should be taken during Cytarabine therapy?
Regular blood tests, infection control measures, antiemetic therapy, and hydration are essential during Cytarabine chemotherapy.
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