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Comprehensive Product Description: Cytotec (Misoprostol)
Cytotec (Misoprostol) is a synthetic prostaglandin E1 analog used to prevent gastric ulcers in patients taking NSAIDs, and medically to induce labor or manage miscarriage or abortion under strict medical supervision.
Cytotec
Generic Name: Misoprostol
Misoprostol (Synthetic Prostaglandin E1 analog)
Other Popular/Common Names:
Misodel
Misotab
Generic Misoprostol
Gastric cytoprotective agent
Cervical ripening agent (in obstetrics)
Therapeutic Class: Gastroprotective / Obstetric agent
Pharmacologic Class: Prostaglandin analog
Schedule: Prescription-only medication (Schedule 4)
Misoprostol works by mimicking prostaglandin E1 (PGE1), leading to:
Inhibition of gastric acid secretion
Increased bicarbonate and mucus production in the stomach
Stimulation of uterine contractions and cervical ripening
It exerts both cytoprotective (gastrointestinal) and uterotonic (gynecological) effects, depending on the dosage and route of administration.
Prevention of NSAID-induced gastric ulcers in high-risk patients
Termination of early pregnancy (in combination with mifepristone)
Management of missed miscarriage or intrauterine fetal death
Induction of labor (in selected clinical settings under medical supervision)
Postpartum hemorrhage control in low-resource settings
Gastrointestinal Use (Ulcer prevention):
Typical Adult Dose: 200 mcg orally 4 times daily with food
Alternatively: 100 mcg QID in patients with intolerance
Obstetric Use (Doses vary by use and protocol):
Medical abortion (with mifepristone): 800 mcg buccally/vaginally 24–48 hours after mifepristone
Labor induction: 25 mcg vaginally every 4–6 hours (hospital use only)
Postpartum hemorrhage: 600–800 mcg orally or sublingually
Note: Use in pregnancy or reproductive health must be under strict medical guidance.
Misoprostol is contraindicated in pregnancy when used for gastric indications
Only trained clinicians should prescribe or administer it for obstetric use
Dosage varies by indication and patient profile
Contraindications:
Known allergy to prostaglandins
Pregnancy (when used for ulcer prevention)
History of uterine surgery or cesarean (in obstetric use)
Suspected ectopic pregnancy
Inflammatory bowel disease
Cardiovascular disease
Elderly patients
Renal or hepatic impairment
Diarrhea
Abdominal pain
Nausea
Flatulence
Constipation
Reproductive (when used for gynecologic purposes):
Uterine cramping
Vaginal bleeding
Fever/chills
Headache
Rare: uterine rupture in high-risk pregnancies
NSAIDs: Used together for ulcer prevention; no major interaction
Oxytocic agents (e.g., oxytocin): Increased risk of uterine hyperstimulation
Antacids containing magnesium: May worsen misoprostol-induced diarrhea
New England Journal of Medicine (2000): Cytotec plus mifepristone is 95% effective in medical abortion within 9 weeks of gestation
WHO Guidelines: Endorse Misoprostol for managing postpartum hemorrhage and missed miscarriage
Cochrane Review (2017): Supports safety and efficacy in labor induction in controlled settings
Frequently Asked Questions (FAQs):
Q: What is Cytotec used for?
A: Cytotec (Misoprostol) is used for preventing NSAID-induced gastric ulcers and managing gynecological indications such as medical abortion, miscarriage, and labor induction.
Q: Can Cytotec be used during pregnancy?
A: It is contraindicated in pregnancy unless used specifically under medical supervision for obstetric purposes (e.g., medical abortion or labor induction).
Q: Is Cytotec safe for ulcer prevention?
A: Yes, when taken as directed in patients at high risk of gastric ulcers from long-term NSAID therapy.
Q: How should Cytotec be taken?
A: For ulcers, it is taken orally 4 times a day with meals. For gynecological use, administration routes include oral, vaginal, or buccal under professional supervision.
Q: Does Cytotec cause bleeding?
A: Yes, when used for gynecological purposes, vaginal bleeding is common due to its effect on the uterus.
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