Cytoxan Injection (Cyclophosphamide) – Comprehensive Product Description
Includes Combo Pack with Blackmores Conceive Well Gold 28 Tablets + 28 Capsules

Cytoxan (Cyclophosphamide injection) is a chemotherapy and immunosuppressive drug used to treat various cancers including leukemia, lymphoma, breast cancer, and ovarian cancer. It is also used in autoimmune conditions like lupus nephritis. It works by interfering with DNA replication in rapidly dividing cells, leading to cell death.

Cytoxan Injection (Cyclophosphamide for Injection, USP)
Paired with: Blackmores Conceive Well Gold, a leading fertility supplement for preconception support.

Cyclophosphamide

Cytoxan

Endoxan

Cyclophosphamide injection

Cycloblastin

Genoxal

Cyclophosphamide is an alkylating agent of the nitrogen mustard class. After hepatic activation, it forms active metabolites that crosslink DNA strands, blocking DNA replication and RNA transcription, leading to cell cycle arrest and apoptosis, particularly in rapidly proliferating cells such as cancer cells and immune cells.

Therapeutic Indications (Uses):
Oncological Uses:
Breast cancer

Ovarian cancer

Non-Hodgkin’s lymphoma

Hodgkin’s lymphoma

Multiple myeloma

Chronic lymphocytic leukemia (CLL)

Acute lymphoblastic leukemia (ALL)

Sarcomas
Systemic lupus erythematosus (SLE) with lupus nephritis

Granulomatosis with polyangiitis (Wegener’s)

Severe autoimmune disorders unresponsive to other treatments

Indication Typical Dosage
Cancer (IV route) 500–1500 mg/m² every 2–4 weeks
High-dose chemotherapy (BMT) Up to 4000–6000 mg/m² total dose
Autoimmune disease 500–1000 mg IV monthly (up to 6 doses)

Route of administration: Intravenous (IV) infusion

Dosage must be adjusted based on renal and hepatic function, hematologic parameters, and type of malignancy

Must be given with adequate hydration and uroprotective agents (e.g. mesna) to prevent bladder toxicity

Form: Lyophilized powder for injection

Strengths Available: 100 mg, 500 mg, 1 g, 2 g

Route: Intravenous

Prescription Required: Yes (cytotoxic medication)

Storage: Store at 2–8°C. Reconstituted solution should be used promptly.

Regular CBC, renal, and hepatic function monitoring required

Urotoxicity prophylaxis with Mesna is often necessary

Contraindicated in pregnancy and lactation

Avoid conception during treatment and for at least 6 months afterward

Blackmores Conceive Well Gold should only be taken after treatment completion and physician clearance

Nausea, vomiting, anorexia

Hair loss (alopecia)

Bone marrow suppression (neutropenia, thrombocytopenia, anemia)

Hemorrhagic cystitis

Infertility (temporary or permanent)

SIADH (syndrome of inappropriate antidiuretic hormone secretion)

Increased risk of infection

Secondary malignancies (with long-term use)
Cytotoxic handling precautions must be followed

Do not administer in pregnancy or breastfeeding

Requires pre- and post-treatment hydration

Monitor for hemorrhagic cystitis, especially at high doses

Long-term use may impair fertility in both genders

Blackmores Conceive Well Gold should be withheld during chemotherapy cycles

Drug Interaction
Allopurinol May enhance bone marrow toxicity
Doxorubicin, other cytotoxics Increased risk of cardiac or marrow toxicity
Anticoagulants Increased bleeding risk due to thrombocytopenia
Live vaccines Risk of severe or fatal infections
Fertility supplements Should be avoided during chemotherapy

CALGB & SWOG trials: Demonstrated efficacy of cyclophosphamide in breast cancer and lymphomas when used in combination chemotherapy regimens

LUNAR Trial (NEJM 2000): Cyclophosphamide effective in lupus nephritis

Bone marrow transplant protocols: Used in high-dose myeloablative regimens
ATC Code: L01AA01

Pharmacologic Class: Alkylating agent, antineoplastic, immunosuppressant

Schedule: Prescription only (S4/Schedule H or equivalent)

WHO Essential Medicines List: Included
Store vial at 2–8°C

Reconstitute with sterile water just before use

Use within the prescribed time frame

Dispose unused drug per cytotoxic waste protocol

Frequently Asked Questions (FAQs):
Q: Can I take Blackmores Conceive Well Gold while on Cytoxan?
No. Fertility supplements should not be taken during chemotherapy. Wait until treatment is completed and cleared by your doctor before restarting.

Q: Is Cytoxan injection safe during pregnancy?
No. Cyclophosphamide is teratogenic and should not be used in pregnancy or when planning conception.

Q: What should I monitor during Cytoxan treatment?
Frequent CBCs, urinalysis, renal/liver function tests, and hydration status are critical. Also watch for signs of hemorrhagic cystitis.

Q: How is Cytoxan given?
Cytoxan is administered by IV infusion, usually in a hospital or oncology center with close monitoring.

Q: How long do Cytoxan's side effects last?
Some effects like nausea or fatigue resolve quickly. Others like hair loss and bone marrow suppression may last weeks. Fertility effects may be prolonged.
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