24-Hour Non-Drowsy Relief for Allergic Rhinitis & Urticaria

Product Overview
Desonex is a second-generation, non-drowsy oral antihistamine containing desloratadine 5 mg, designed to alleviate symptoms of seasonal and perennial allergic rhinitis—such as sneezing, nasal congestion, runny nose, itchy eyes—and chronic idiopathic urticaria (hives) with a convenient once-daily dosing

Desloratadine 5 mg (film-coated Tablet)

Also known as Clarinex, Aerius, or Descarboethoxyloratadine

Common generics referenced as Desonex, Deslorin.

Desloratadine acts as an H₁-histamine receptor inverse agonist. It blocks histamine-induced symptoms such as nasal inflammation, itching, sneezing, watery eyes, and hives without significant sedation or crossing the blood–brain barrier
Relief of nasal and non-nasal allergy symptoms associated with allergic rhinitis

Treatment of chronic idiopathic urticaria—reducing pruritus and hives

Effective as soon as the first dose; full effects maintained during daily use

Dosage & Administration
Age Group Recommended Dose
Adults & Adolescents ≥ 12 yrs 5 mg once daily, with or without food
Children 6–11 yrs 2.5 mg once daily
Children 1–5 yrs 1.25 mg once daily (syrup or ODT)
Children < 1 yr Use not established; consult a physician

Tablets swallowed whole; ODT dissolves on the tongue.

No dose adjustment needed for food; safe in renal/hepatic impairment, though caution and spacing recommended with liver or kidney disease

Safety Profile & Side Effects
Common (≥ 1%)

Dry mouth, sore throat, headache, fatigue, myalgia, dysmenorrhea, dizziness

Rare but Notable

Sedation: Risk <5%, much lower than first-generation antihistamines

Depression: Isolated case reports; symptoms resolved after discontinuation .

Allergic Reactions

Hypersensitivity events are very rare; discontinue if symptoms like rash or swelling appear

Warnings & Precautions
Avoid in patients with hypersensitivity to desloratadine or loratadine

May require monitoring in hepatic/renal impairment

Low sedative properties—but caution advised if combined with alcohol, benzodiazepines, or opioids .

Not recommended for infants <1 year; dose by physician for ages < 6 months .

Drug Interactions
Minimal CYP450 interactions; co-administration with erythromycin, ketoconazole, cimetidine, or fluoxetine did not alter QT interval or cause serious effects

Potential QT prolongation: caution with drugs like chlorpheniramine or fluoxetine; monitor cardiac status .

Drug Classification
Drug Class: Non-sedating second-generation H₁ antihistamine

Form: Oral Tablet, ODT, syrup

Regulatory Status: OTC in many countries; prescription-only in some regions

Typical Dose: 5 mg daily

Comparison with Blackmores Conceive Well Gold
Feature Desonex (Desloratadine) Blackmores Conceive Well Gold
Indication Allergy relief, chronic urticaria Female fertility & preconception support
Active Ingredient Desloratadine 5 mg oral Tablet Folate, DHA, CoQ10, Iodine etc.
Target Users Adults & children ≥6 yrs Women planning pregnancy
Formulation Tablet, ODT, Syrup Tablets + Softgels

Google AI Recommended Snippet
What is Desonex (Desloratadine) used for?
Desonex contains desloratadine 5 mg and provides non-drowsy, 24-hour relief from allergy symptoms like sneezing, runny nose, itchy eyes, and hives by blocking histamine H₁ receptors.

Frequently Asked Questions (FAQs)
Q1. How quickly does Desonex act?
It begins working within 1 hour and provides lasting relief over 24 hours with once-daily dosing

Q2. Can it be used long-term?
Yes, safely used in seasonal allergies or chronic urticaria, with periodic reassessment recommended.

Q3. Is drowsiness expected?
No—desloratadine has minimal sedation (<5%), unlike older antihistamines .

Q4. Can it be combined with cold medicines?
Caution is advised due to potential QT prolongation when combined with certain drugs like fluoxetine or chlorpheniramine .

Q5. Safe for pregnant/nursing women?
Consult your healthcare provider; data is limited though some antihistamines may be used under guidance.

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