Dymista is a dual-therapy nasal spray combining azelastine hydrochloride (antihistamine) and fluticasone propionate (corticosteroid) in a single formulation. It offers rapid relief of nasal allergy symptoms—sneezing, congestion, itching, and runny nose—from seasonal and perennial allergic rhinitis

Azelastine HCl 125 µg – Fast-acting H₁-histamine receptor blocker

Fluticasone propionate 50 µg – Potent glucocorticoid reducing nasal inflammation

Each Bottle contains approximately 120 metered doses (62 g suspension)


Other Names & Drug Class
Generic: Azelastine/Fluticasone nasal spray

Drug class: Intranasal antihistamine + corticosteroid combination

Mode of Action
Azelastine blocks histamine receptors and stabilises mast cells, reducing early allergic responses

Fluticasone inhibits inflammatory mediator release and suppresses late-phase nasal inflammation

Combined, they treat both immediate and delayed symptoms more effectively than either alone .

Indications & Uses
Adults and adolescents (≥12 yrs) with moderate–severe seasonal or perennial allergic rhinitis insufficiently controlled by monotherapy

Provides relief within minutes (nasal symptoms ~5 min; ocular symptoms ~10 min)

Adults & Adolescents (12+): 1 spray per nostril twice daily (morning & evening)

Duration: Up to 6 months, with ongoing monitoring; efficacy typically maintained long-term

Contraindicated in children <12 yrs due to lack of established safety
medsinfo.com.au

Administration Tips: Shake well, avoid eye contact, store upright at room temperature, discard after 120 doses .

Efficacy & Clinical Evidence
Dymista was proven to alleviate symptoms significantly faster than either azelastine or fluticasone alone, with sustained relief over one-year trials

Safety, Side-Effects & Precautions
Common (≥2%): Epistaxis, headache, nasal discomfort, dysgeusia, cough, upper respiratory infections
Uncommon/Rare:

Nasal ulcers, dryness, throat irritation

Somnolence (especially children), elevated intraocular pressure, cataracts, growth retardation with prolonged use

Systemic steroid effects: Possible with long-term high-dose use — monitor adrenal function if needed

Serious risks: Nasal septal perforation, hypersensitivity, mucosal damage — more likely with prolonged use

Precautions:

Not for use with ritonavir or strong CYP3A4 inhibitors (e.g., ketoconazole) due to increased systemic fluticasone levels
medsinfo.com.au

Avoid in active nasal infections, glaucoma, adrenal disorders

Interactions
Ritonavir and other CYP3A4 inhibitors may precipitate adrenal suppression

Cimetidine may increase azelastine levels

CNS depressants (e.g., sleeping pills, opioids) may accentuate drowsiness

Drug Classification
Prescriptions medication in many countries (S2 Pharmacy Medicine in Australia)

Category: Combination nasal antihistamine + corticosteroid

FAQs
Q1: How fast does Dymista work?
A1: Symptom relief begins ~5 minutes for nasal and ~10 minutes for ocular symptoms post initial dose

Q2: Can it be used year-round?
A2: Yes, up to 6 months; monitor for side-effects.

Q3: Is it suitable for children?
A3: Recommended only for ages 12+; safety in <12 yrs is not established


Q4: Can it cause steroid side effects?
A4: Systemic effects are rare at recommended doses but possible with prolonged use – monitor adrenal health.

Q5: Can it interact with my medications?
A5: Avoid combining with ritonavir or CYP3A4 inhibitors; caution with CNS depressants or cimetidine

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What is Dymista nasal spray used for?
Dymista is an intranasal spray combining azelastine and fluticasone for rapid relief of moderate to severe allergic rhinitis symptoms, including congestion, itching, sneezing, and runny nose.

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