Aldactone (Spironolactone) – Potassium-Sparing Diuretic for Edema, Hypertension & Hormonal Acne | EZ Chemist Online Pharmacy
Aldactone Spironolactone Tablets – Treat High Blood Pressure, Heart Failure, PCOS & Acne | Buy Online at EZ Chemist
What is Aldactone used for?
Aldactone (spironolactone) is a potassium-sparing diuretic used to treat high blood pressure, heart failure, edema, primary hyperaldosteronism, and hormonal conditions like acne and polycystic ovary syndrome (PCOS). It works by blocking aldosterone, reducing fluid retention and androgen levels.
Brand Name: Aldactone

Generic Name: Spironolactone

Form: Oral Tablets

Available Strengths: 25 mg, 50 mg, 100 mg

Drug Class: Potassium-sparing diuretic; Aldosterone antagonist

Prescription Required: Yes

Manufacturer: RPG Life Sciences / Pfizer (depending on region)

Availability in India: Buy Aldactone Online – EZ Chemist
Spironolactone – a synthetic aldosterone receptor antagonist with diuretic and antiandrogenic properties
Spironolactone 25 mg / 50 mg / 100 mg
Generic Names: Spironolactone

Other Brands: Aldactazide (with hydrochlorothiazide), CaroSpir (oral suspension), Inspra (Eplerenone – related compound)

Class: Potassium-sparing diuretic, Anti-androgen
Spironolactone competitively inhibits aldosterone at receptors in the distal renal tubules, promoting sodium excretion and potassium retention. It also blocks androgen receptors and inhibits androgen synthesis, making it effective in hormonal acne and PCOS
Diuretic via aldosterone antagonism
Anti-hypertensive via decreased blood volume
Anti-androgenic via inhibition of 5α-reductase and receptor blockade
Cardiovascular / Renal:
Hypertension (especially in patients with hypokalemia or resistant HTN)

Heart Failure (NYHA Class III–IV) – reduces mortality when added to standard therapy

Edema in congestive heart failure, liver cirrhosis, or nephrotic syndrome

Primary Hyperaldosteronism – diagnostic and maintenance treatment
Polycystic Ovary Syndrome (PCOS)
Hirsutism in women
Acne vulgaris (hormonal, adult-onset)

Female pattern hair loss (off-label)

Dosage and Administration:
Indication Usual Adult Dose Frequency
Hypertension 25–50 mg/day Once or in divided doses
Heart Failure 25 mg/day Once daily (with standard therapy)
Edema 25–200 mg/day Single or divided dose
Hyperaldosteronism 100–400 mg/day Divided doses
PCOS, Acne, Hirsutism 50–200 mg/day Adjusted to tolerance and effect

Take with food to reduce gastrointestinal side effects

Adjust dosage based on serum potassium and renal function
Pregnancy Category: C (risk cannot be ruled out)

Pediatric Use: Off-label in some nephrotic conditions

Geriatric Use: Monitor renal function closely

Lactation: Excreted in breast milk; avoid or monitor infant closely
Gynecomastia (in men)

Menstrual irregularities
Fatigue or dizziness
Nausea, vomiting
Breast tenderness
Hyperkalemia – potentially life-threatening

Renal impairment – monitor eGFR and creatinine
Metabolic acidosis
Rare: agranulocytosis, liver dysfunction
Monitor serum potassium and renal function regularly
Avoid potassium supplements or salt substitutes containing potassium
Do not combine with ACE inhibitors or ARBs without medical supervision
Caution in elderly, diabetics, and those with kidney disease
Spironolactone has shown tumorigenic potential in rats; avoid unnecessary long-term use
Increased Risk of Hyperkalemia With:

ACE inhibitors (e.g., lisinopril)

ARBs (e.g., losartan)
Potassium supplements

NSAIDs: Reduce diuretic efficacy

Digoxin: Spironolactone may increase digoxin levels

Lithium: Toxicity risk increased

Alcohol: May exacerbate hypotension or dizziness
RALES Trial (NEJM, 1999) – Spironolactone reduced mortality by 30% in severe heart failure patients.
Store below 30°C
Protect from moisture and light
Keep out of reach of children

Frequently Asked Questions (FAQs):
Q1: What is Aldactone used for?
Aldactone is used for high blood pressure, heart failure, fluid retention (edema), hormonal acne, and PCOS. It blocks aldosterone and helps balance fluids and hormones.

Q2: Can Aldactone help with acne or PCOS?
Yes. It is commonly used off-label for women with hormonal acne or PCOS-related hirsutism due to its anti-androgenic effects.

Q3: Is Aldactone a diuretic or hormone medicine?
Aldactone is both a potassium-sparing diuretic and an anti-androgen, making it useful in cardiovascular and hormonal conditions.

Q4: Does Aldactone cause high potassium?
Yes, hyperkalemia is a serious side effect. Avoid high-potassium foods and supplements unless advised by your doctor.

Q5: Can men take Aldactone?
Yes, for heart failure, hypertension, or hyperaldosteronism. However, it may cause gynecomastia due to its anti-androgenic properties.

Q6: Is it safe in pregnancy or breastfeeding?
Not recommended during pregnancy. Use in lactation only if necessary and under medical supervision.
RALES Study – NEJM (1999): Spironolactone improves survival in severe heart failure

Endocrine Reviews (2006): Role of spironolactone in hyperandrogenic states

JAMA Dermatology (2017): Spironolactone efficacy in adult female acne

FDA Prescribing Information – Aldactone
Shop Aldactone 25 mg / 50 mg / 100 mg Tablets online at EZ Chemist Pharmacy for safe and effective treatment of hypertension, fluid retention, PCOS, and hormonal acne. Trusted brands, pharmacist support, and fast delivery across India.

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