Generic Cordarone Injection (Amiodarone Hydrochloride for Injection)
Compared with: Blackmores Conceive Well Gold 28 Tablets + 28 Capsules

Generic Cordarone Injection (Amiodarone HCl 150 mg/3 mL) is a class III antiarrhythmic indicated for life‑threatening ventricular fibrillation and unstable ventricular tachycardia. A typical IV regimen is a 300 mg bolus over 10 minutes, followed by a continuous infusion (1 mg/min × 6 h, then 0.5 mg/min × 18 h), providing rapid control of refractory arrhythmias and hemodynamic stabilization
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Amiodarone Hydrochloride – 150 mg per 3 mL (50 mg/mL) sterile solution
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Pacerone® Injection (brand)

Amiodarone IV/IM

Class III Antiarrhythmic

Cordarone IV Solution
Amiodarone prolongs cardiac repolarization by blocking K⁺ channels (phase 3), with additional Na⁺ and Ca²⁺ channel blockade and noncompetitive α‑ and β‑adrenergic inhibition. This multimodal action suppresses reentrant and automatic arrhythmias in both atrial and ventricular tissues .

Pulseless Ventricular Fibrillation & Unstable Ventricular Tachycardia: Refractory to CPR and defibrillation
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Hemodynamically Unstable VT: Acute management in critical care.

Off‑Label: IV rate control in atrial fibrillation/flutter when rapid control is needed; adjunct to electrical cardioversion.

Adult IV Regimen
Initial Bolus (Arrest): 300 mg IV/IO over 10 minutes (15 mg/min)
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Supplemental Bolus (if needed): 150 mg over 5 minutes.

Loading Infusion: 1 mg/min IV for 6 hours (360 mg total)
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Medscape Reference

Maintenance Infusion: 0.5 mg/min IV for 18 hours (540 mg total)
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Maximum 24‑h Dose: Do not exceed 2.2 g to minimize hypotension risk.

Pediatric (Off‑Label ACLS)
Initial: 5 mg/kg IV/IO (max 300 mg) over 5 minutes.

Follow‑Up: May repeat up to two times; infusion at 5 mcg/kg/min thereafter
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Bolus undiluted or dilute in ≥50 mL D₅W for infusion.

Use a non‑PVC line for concentrations >2 mg/mL.

Monitor ECG, BP, and oxygen continuously.

Formulation: Sterile, preservative‑free solution, 50 mg/mL.

Presentation: 3 mL single‑dose ampoules.

Route: Intravenous (preferred) or intramuscular.

Storage: 20–25 °C; protect from light; use immediately after opening.

Pregnancy: Category D – fetal thyroid and neurologic risk; use only if maternal benefit outweighs risk.

Breastfeeding: Excreted in milk; monitor infant for thyroid dysfunction.

Renal/Hepatic Impairment: No formal adjustment; monitor for accumulation given long half‑life (50–60 days).

Elderly: Start at lower infusion rates due to increased sensitivity.

Common:

Hypotension (10 %)
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Bradycardia, heart block

Phlebitis at infusion site

Serious:

QT Prolongation → Torsades de Pointes (rare)

Pulmonary Toxicity (fibrosis with prolonged use)

Thyroid Dysfunction: Both hypo‑ and hyperthyroidism

Hepatotoxicity and Neurologic Effects in chronic therapy

Continuous Monitoring: ECG and hemodynamics during infusion.

Rebound Arrhythmias: Taper infusion rate gradually.

Pulmonary & Thyroid Surveillance: In prolonged therapy, perform periodic chest imaging and thyroid panels.

Drug‑Induced Liver Injury: Obtain baseline LFTs; monitor periodically.

Concomitant Agent Interaction Recommendation
Warfarin ↑INR via CYP2C9/3A4 inhibition Reduce warfarin dose; monitor INR
Digoxin ↑Digoxin levels via P‑gp inhibition Reduce digoxin dose; monitor levels
Statins (simvastatin, lovastatin) ↑Myopathy risk via CYP3A4 inhibition Use lower statin dose; monitor for toxicity
Beta‑Blockers / CCBs Additive bradycardia and AV block Adjust doses; monitor ECG
Class I Antiarrhythmics ↑Arrhythmia risk (e.g., disopyramide, flecainide) Avoid co‑administration

FAQs – Generic Cordarone Injection
Q1. How soon will arrhythmias respond?
A: Ventricular arrhythmias often terminate within 10–15 minutes of the initial bolus; continued infusion maintains suppression
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Q2. Can repeat boluses be given?
A: Yes—150 mg may be repeated once or twice at 5‑minute intervals if VF/VT persists, up to a 24‑h total of 2.2 g
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Q3. What monitoring is essential?
A: Continuous ECG, noninvasive BP, and pulse oximetry throughout infusion.

Q4. How to manage hypotension?
A: Slow or pause the infusion; administer IV fluids or vasopressors as needed.

Q5. Can Cordarone be given IM?
A: IM route is possible but painful and less predictable; IV infusion is preferred.

Q6. How to transition to oral amiodarone?
A: Begin oral therapy (200 mg TID) once stable; overlap IV and oral for ≥24 hours.

Q7. How should vials be stored?
A: Store at controlled room temperature, protect from light, discard if ampoule is compromised.

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