Generic Coversyl Plus (Perindopril + Indapamide)

Generic Coversyl Plus is a combination of Perindopril, an ACE inhibitor, and Indapamide, a thiazide-like diuretic. It is used to treat high blood pressure (hypertension) when monotherapy is insufficient. This dual-action medicine lowers blood pressure by relaxing blood vessels and promoting fluid excretion. It helps reduce cardiovascular risk and kidney complications in hypertensive patients.

Generic Coversyl Plus (Perindopril + Indapamide)

Perindopril Erbumine 2 mg + Indapamide 0.625 mg

Perindopril Erbumine 4 mg + Indapamide 1.25 mg

Perindopril Erbumine 8 mg + Indapamide 2.5 mg

Perindopril Erbumine – ACE Inhibitor

Indapamide – Thiazide-like Diuretic
Generic Names: Perindopril + Indapamide

Brand Names: Coversyl Plus, Coversum Plus, Prestarium Plus, Preterax
Class: Antihypertensive Combination Therapy

This combination medication works through two synergistic mechanisms:

Perindopril (ACE Inhibitor):

Blocks angiotensin-converting enzyme (ACE)

Reduces production of angiotensin II

Leads to vasodilation, reduced aldosterone secretion, and decreased blood pressure

Indapamide (Thiazide-like Diuretic):

Inhibits sodium reabsorption in the distal tubules

Promotes excretion of sodium and water, reducing plasma volume

Has additional vasodilatory properties

The combination reduces peripheral vascular resistance and blood volume, offering better blood pressure control and organ protection, especially in hypertensive patients at risk of cardiovascular complications.

Essential Hypertension (high blood pressure), especially when monotherapy with Perindopril is insufficient

Hypertensive patients with high cardiovascular risk

Nephropathy prevention in diabetic or elderly patients (off-label use)

Lower risk of stroke and myocardial infarction

Protection of renal function in hypertensive patients

Improved patient compliance with fixed-dose combination therapy

Strength Recommended Starting Dose Maintenance Dose
Low-dose 2 mg Perindopril + 0.625 mg Indapamide Once daily
Standard 4 mg Perindopril + 1.25 mg Indapamide Once daily
High-dose 8 mg Perindopril + 2.5 mg Indapamide Once daily

To be taken once daily, preferably in the morning before meals

Titration is based on blood pressure response and tolerability

Do not exceed prescribed dose without medical consultation

Prescription Required: Yes

Dosage Form: Oral tablet

Route of Administration: Oral

Onset of Effect: Within 4–6 hours

Time to Peak Effect: 1–2 weeks

Half-life: Perindoprilat (3–10 hrs), Indapamide (14–24 hrs)
Headache

Dizziness or light-headedness

Persistent dry cough

Fatigue

Gastrointestinal discomfort

Increased urination (especially in the first few weeks)

Angioedema (facial/throat swelling – medical emergency)

Electrolyte imbalance (low potassium or sodium)

Severe hypotension

Dehydration

Arrhythmia (in case of electrolyte disturbances)

Photosensitivity

Pregnancy: Contraindicated (Pregnancy Category D) – Risk of fetal injury or death

Lactation: Use only if benefits outweigh potential risks

Kidney Impairment: Adjust dose; monitor renal function and electrolytes

Hepatic Impairment: Use cautiously

Electrolyte Monitoring Required: Especially potassium and sodium levels

Not for use in patients with:

Known hypersensitivity to sulfonamides

History of angioedema with ACE inhibitors

Severe renal impairment (creatinine clearance <30 mL/min)

Drug/Class Interaction Effect
NSAIDs (e.g., ibuprofen) Reduced antihypertensive effect; risk of kidney damage
Potassium-sparing diuretics Risk of hyperkalemia
Lithium Increased lithium toxicity risk
Alcohol May enhance hypotensive effects
Antidiabetics Risk of hypoglycemia
Corticosteroids/Diuretics May increase risk of hypokalemia

The ADVANCE study and PROGRESS trial demonstrated that Perindopril + Indapamide combination significantly reduces the risk of stroke, death, and cardiovascular events in patients with hypertension and type 2 diabetes.

Therapeutic Class: Antihypertensive

Pharmacologic Classes:

ACE Inhibitor (Perindopril)

Thiazide-like Diuretic (Indapamide)

ATC Code: C09BA04

Store below 25°C

Protect from light and moisture

Keep out of reach of children

Do not use beyond expiry date mentioned on the pack

Frequently Asked Questions (FAQ)
Q: How is Generic Coversyl Plus different from regular Coversyl?
A: Regular Coversyl contains only Perindopril. Generic Coversyl Plus combines Perindopril with Indapamide for enhanced blood pressure control and fluid regulation.

Q: Can I stop taking Generic Coversyl Plus if my blood pressure is normal?
A: No. Discontinuing antihypertensive treatment without medical advice can cause rebound hypertension or cardiovascular complications.

Q: Does it cause frequent urination?
A: Yes, Indapamide has a mild diuretic effect, especially in the initial weeks. This usually stabilizes with continued use.

Q: Can I take Generic Coversyl Plus with food?
A: It is best taken before meals, as food can slightly reduce absorption, especially of Perindopril.

Q: Is routine blood test monitoring needed?
A: Yes. Regular monitoring of blood pressure, kidney function, electrolytes (especially potassium and sodium) is recommended.

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