Comprehensive Product Description: Generic Crestor (Rosuvastatin Calcium)

Generic Crestor (Rosuvastatin Calcium) is a statin used to lower bad cholesterol (LDL), raise good cholesterol (HDL), and reduce triglycerides. It is prescribed to reduce the risk of cardiovascular events such as heart attacks and strokes in patients with elevated cholesterol or known heart disease.

Generic Crestor Tablets
(Rosuvastatin Calcium)

Rosuvastatin Calcium

Generic Rosuvastatin

Statin cholesterol tablet

Rosuvastatin Sodium

Rosulip, Rovista (other branded generics)

Therapeutic Class: Lipid-lowering Agent

Pharmacological Class: HMG-CoA Reductase Inhibitor (Statin)

Schedule: S4 – Prescription Only Medicine (Australia)

Rosuvastatin inhibits HMG-CoA reductase, the rate-limiting enzyme in cholesterol biosynthesis in the liver. This leads to:

Reduced LDL-C (bad cholesterol)

Increased HDL-C (good cholesterol)

Lowered triglycerides

Decreased production of VLDL and total cholesterol

Rosuvastatin also stabilises atherosclerotic plaques and exhibits anti-inflammatory and endothelial benefits, reducing the risk of cardiovascular events.

Primary hypercholesterolemia (including heterozygous familial)

Mixed dyslipidemia

Homozygous familial hypercholesterolemia

Prevention of cardiovascular events in high-risk individuals

Adjunct to diet and lifestyle modification for cholesterol management

Form: Oral film-coated tablets (usually available in 5 mg, 10 mg, 20 mg, and 40 mg strengths)
Initial: 5 mg to 10 mg once daily
Maintenance: Adjust up to 20 mg once daily as needed
Maximum: 40 mg/day in selected high-risk patients only (e.g. familial hypercholesterolemia)
Administration:
Taken once daily at any time, with or without food

Regular lipid profile monitoring advised (every 4–12 weeks after initiation or dose adjustment)

Prescription Required: Yes

Generic Availability: Yes

Route of Administration: Oral

Storage: Store below 25°C, protect from moisture and light

Packaging: Available in blister strips or bottles (30 or 90 tablets)
Active liver disease or unexplained persistent elevated liver enzymes
Pregnancy and lactation

Hypersensitivity to rosuvastatin or other statins

Concomitant use with cyclosporine
Warnings and Precautions:
Monitor liver function before starting and during treatment

Risk of myopathy and rhabdomyolysis; watch for unexplained muscle pain or weakness

Use lower starting dose in Asian patients, elderly, or those with renal impairment

Not recommended for children unless prescribed by a specialist
Common (1–10%):
Headache

Nausea

Constipation

Abdominal pain

Muscle pain (myalgia)

Asthenia (weakness)

Less Common (<1%):
Increased liver enzymes

Dizziness

Rash

Proteinuria

Memory issues (rare, reversible)
Rhabdomyolysis

Liver failure

Hypersensitivity reactions

Immune-mediated necrotizing myopathy
Caution With:

Cyclosporine – increases rosuvastatin levels significantly

Gemfibrozil or other fibrates – increased risk of muscle toxicity

Warfarin – may enhance anticoagulant effect

Antacids – may reduce rosuvastatin absorption (take 2 hours apart)

Protease inhibitors (e.g. ritonavir) – increase rosuvastatin levels

Alcohol – increases liver-related side effect risk

Clinical Studies & Efficacy:
JUPITER Trial: Demonstrated a 44% reduction in major cardiovascular events in patients with normal LDL but elevated C-reactive protein using rosuvastatin.

GALAXY Program: Showed significant LDL reductions and plaque stabilization benefits.

Rosuvastatin demonstrated superiority over simvastatin and pravastatin in LDL reduction at comparable doses (NEJM, 2005).

Frequently Asked Questions (FAQs)
Q: How long does it take for Generic Crestor to lower cholesterol?
A: Results are typically seen within 2 to 4 weeks, with full effect by 8 weeks. Regular lipid testing helps guide therapy.

Q: Can I take rosuvastatin with food?
A: Yes, Generic Crestor can be taken with or without food.

Q: What should I do if I miss a dose?
A: Take it as soon as you remember. If it’s almost time for your next dose, skip the missed one. Do not double-dose.

Q: Can rosuvastatin be stopped suddenly?
A: Discontinuation should only be done under medical supervision, as stopping may lead to a rebound in cholesterol levels and cardiovascular risk.

Q: Is it safe in pregnancy?
A: No. Rosuvastatin is contraindicated in pregnancy due to potential harm to the fetus. Use effective contraception during treatment.
Buy Generic Crestor Online Australia

Rosuvastatin 10mg Tablets

Best statin for cholesterol

Prescription cholesterol medicine

Statin for LDL and triglyceride control

Order rosuvastatin calcium EZ Chemist

Heart health and lipid-lowering medication

Crestor generic 10mg 20mg online

Cholesterol-lowering statin tablets

Generic Crestor statin Australia