La Roche‑Posay Toleriane Ultra Dermallergo Serum (20 ml)
A hydrating, soothing serum formulated with 0.1% Neurosensine™, osmolytes, thermal spring water, and hyaluronic acid to calm reactive, ultra-sensitive, and allergy-prone skin. Provides immediate comfort and moisture for up to 48 hours.
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“What is Toleriane Ultra Dermallergo Serum?”

A minimalist, fragrance- and alcohol-free serum enriched with Neurosensine™ and thermal spring water, designed to soothe redness, irritation, and discomfort in ultra-sensitive skin, with clinical proof of barrier repair and 48‑hour hydration.

Neurosensine™ (Acetyl Dipeptide‑1 Cetyl Ester, 0.1%): A neuro-soothing peptide that calms skin through nerve-cell signaling and release of met-enkephalin
laroche-posay.com.au

Osmolyte + Glycerin + Pentylene Glycol: Hydrating agents that reinforce the skin barrier and retain moisture

Thermal Spring Water: Naturally rich in selenium and minerals; soothes inflammation and provides antioxidant benefits

Sodium Hyaluronate: Humectant that hydrates and plumps the skin surface

Mode of Action
Neuro-soothing: Neurosensine™ signals nerve cells to release opioid-like peptides, reducing skin discomfort and
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Barrier Reinforcement: Osmolytes and humectants strengthen intercellular lipids, reducing transepidermal water loss

Long-lasting Hydration: Glycerin and HA provide up to 48 hours of moisture retention

Antioxidant Soothing: Mineral-rich water calms irritation and protects from environmental stress

Uses & Indications
Immediate relief from skin tightness, dryness, redness, itchiness in ultra-sensitive or allergic skin

Daily serum for reactive skin needing barrier restoration and comfort

Suitable for face, neck, and sensitive eye area
Dosage & Administration
Shake well and apply 2–4 drops, morning and evening, to clean, dry skin

Can be used alone or layered before moisturizer

For a cooling effect, store the serum in the fridge for 30 minutes before use

Safety & Side-Effects
Hypoallergenic, fragrance‑ and alcohol‑free, non‑comedogenic, ophthalmologist-tested

Minimal side effects; rare reports of redness, itchiness, or stinging—often from other ingredients (e.g., propylene glycol)

Warnings & Cautions
External use only

Avoid on open wounds or severe eczema

Patch test recommended for extremely sensitive users

Discontinue if irritation persists

Compatible with other skincare products; avoid layering with strong actives unless advised

Drug Classification
OTC cosmeceutical serum, not classified as a medication

Falls under barrier repair and sensitive-skin care

Drug Interactions
No systemic drug interactions expected—topical application only

Safe to use with sunscreen, moisturizers, and mild actives

Fragrance or alcohol-free formula reduces interaction risk

Clinical Evidence & Results
Clinical study (n=48, 4 weeks, twice daily) showed:

69% reduction in stinging

54% reduction in dryness

46% reduction in flakiness

Hydration metrics: Up to 48-hour moisture retention confirmed via corneometry
laroche-posay.sg

Consumer reviews note rapid comfort, smoother texture, less visible redness

FAQ (Q&A Format)
Q: How soon will I feel relief?
A: Most users report immediate soothing; full 48 h hydration within one application .

Q: Is it suitable for eye area?
A: Yes—ophthalmologist-tested, gentle around eyes and on eyelids .

Q: Can I use it during flares or allergic reactions?
A: Yes, designed for reactive skin. However, discontinue if severe irritation occurs.

Q: Will it leave a sticky residue?
A: No—light, fresh, non-sticky texture (though some users report a slight sheen if over-applied) .

Q: Can I use this with other serums?
A: Yes—ideal as a calming base before other targeted treatments; avoid layering too many actives.

La Roche‑Posay Toleriane Ultra Dermallergo Serum, neurosensine serum 20 ml, sensitive skin soothing serum, barrier repair serum, EZ Chemist sensitive skin serum