Panadol Osteo 665mg Caplets – Long-lasting Osteoarthritis Pain Relief
Panadol Osteo 665mg provides sustained-release paracetamol for effective and long-lasting relief of osteoarthritis pain and chronic joint discomfort.

Product Name: Panadol Osteo 665mg – 96 Caplets

Active Ingredient: Paracetamol 665mg (modified release)

Form: Caplets (bi-layer, extended-release)

Drug Class: Analgesic / Antipyretic

Intended Use: Osteoarthritis, chronic pain

Manufacturer: GSK Consumer Healthcare

Available At: EZ Chemist Online Pharmacy
Paracetamol 665mg (500mg immediate release + 165mg sustained release)

Extended-release paracetamol

Modified-release acetaminophen

Osteoarthritis pain reliever

Dual-layer Panadol

Panadol Osteo contains a patented bi-layer formulation that releases 500mg of paracetamol immediately for rapid onset of pain relief, followed by 165mg released slowly over 8 hours to maintain therapeutic levels. It works centrally in the brain to inhibit prostaglandin synthesis, modulating pain and reducing fever without anti-inflammatory effects.

Panadol Osteo 665mg is recommended for:

Osteoarthritis (OA)

Chronic musculoskeletal pain

Lower back pain

Persistent headaches or tension-type headaches

Pain management in elderly patients

Mild to moderate joint and soft tissue pain

2 caplets every 6 to 8 hours as required (maximum 6 caplets in 24 hours)

Do not exceed 3990mg (6 x 665mg) in 24 hours

Swallow whole with water; do not crush, chew, or dissolve

Not recommended for children under 12 years

Prescribing & Professional Information
Recommended first-line analgesic in osteoarthritis per RACGP and NICE guidelines.

Long-acting formulation allows reduced frequency of dosing (3 times daily).

Panadol Osteo is generally well tolerated and suitable for:

Long-term use in older adults

Gastro-sensitive patients who cannot tolerate NSAIDs

Individuals with peptic ulcer disease or anticoagulant use

Common (Rare with recommended dose):

Nausea

Vomiting

Abdominal discomfort

Rare but serious:

Liver toxicity in overdose

Skin hypersensitivity reactions (rash, hives)

Warnings & Precautions
Do not exceed recommended dose

Avoid use with alcohol or other hepatotoxic drugs

Use caution in liver impairment, malnutrition, or chronic alcohol use

Not suitable for those with paracetamol hypersensitivity

Drug Interactions
Use with caution or consult a doctor if taking:

Warfarin (increased bleeding risk with prolonged use)

Other paracetamol-containing products (risk of overdose)

Anticonvulsants or rifampicin (increased hepatotoxicity risk)

A 2016 Cochrane Review on osteoarthritis pain relief concluded that paracetamol remains effective in many mild-to-moderate OA patients, and extended-release formulations like Panadol Osteo offer improved compliance and tolerability, especially in older adults.

Store below 25°C

Protect from heat and moisture

Keep out of reach of children

FAQs
Q1. What makes Panadol Osteo different from regular Panadol?
A: Panadol Osteo contains 665mg paracetamol in a dual-release formulation—immediate and sustained action—providing relief for up to 8 hours.

Q2. Can I take Panadol Osteo with other medicines?
A: Yes, but avoid other products containing paracetamol. Check with a doctor if you’re on warfarin or liver-metabolised medications.

Q3. Is it safe for long-term use?
A: Yes, Panadol Osteo is suitable for long-term use in chronic pain under medical supervision, especially for osteoarthritis.

Q4. Can I take this alongside Blackmores Conceive Well Gold?
A: Generally yes, but confirm with your healthcare provider if using both, especially during pregnancy or planning to conceive.

Q5. Can I use it during pregnancy or breastfeeding?
A: Paracetamol is considered safe during pregnancy, but always consult a healthcare professional before use.

Schedule 2 (Pharmacy Medicine) in Australia

OTC (Over-the-Counter) availability

Non-narcotic analgesic

Panadol Osteo 665mg, Paracetamol, Analgesic, Chronic Pain, Osteoarthritis Relief, Long Acting, Extended Release, OTC, EZ Chemist